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Atmospheric pressure chemical extraction ionization source and atmospheric pressure chemical extraction ionization mass spectrometry analysis method

A technology of ionization source and ionization mass, which is applied in the field of mass spectrometry, can solve the problems that the extraction ionization source cannot directly analyze non-polar molecules, the surface chemical ionization source cannot continuously inject samples for analysis, and cannot desorb biological macromolecules, etc., so as to improve research The effect of reaction mechanism, compact structure and ingenious design

Inactive Publication Date: 2011-12-14
EAST CHINA UNIV OF TECH
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is to solve the problem that the surface chemical ionization source cannot be continuously sampled and analyzed and cannot desorb biological macromolecules, and the problem that the extraction ionization source cannot directly analyze non-polar molecules, and provides a method with low assembly difficulty and low manufacturing cost. Low, high ionization efficiency, high sensitivity atmospheric pressure chemical extraction ionization source

Method used

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  • Atmospheric pressure chemical extraction ionization source and atmospheric pressure chemical extraction ionization mass spectrometry analysis method
  • Atmospheric pressure chemical extraction ionization source and atmospheric pressure chemical extraction ionization mass spectrometry analysis method
  • Atmospheric pressure chemical extraction ionization source and atmospheric pressure chemical extraction ionization mass spectrometry analysis method

Examples

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example 1

[0051] Example 1: Detection of non-polar molecules

[0052] Test sample: methanol solution, components to be tested: benzene and naphthalene

[0053] Detection process: using Figure 1c installation. Parameter setting: a=10mm, b=10mm, α=60°, β=80°, r=80°. The reagent passed into the discharge tube is methanol water acetic acid mixture (1:1:0.1%, volume ratio), the flow rate is 0.5μL / min, the carrier gas is nitrogen, the flow rate is 20psi, and the high voltage is positive voltage 3.5kV; The methanol solution of benzene or naphthalene was used at a flow rate of 0.5 μL / min, and the carrier gas was nitrogen at a flow rate of 20 psi. The above device is used in conjunction with the LTQ mass spectrometer.

[0054] result: Figure 2a and Figure 2b Mass spectra of benzene and naphthalene showing typical nonpolar molecules, where Figure 2a The radical cation of benzene (m / z 78), the protonated benzene ion (m / z 79) and the radical cation generated by Burch reduction (m / z 80)...

example 2

[0057] Example 2: Detection of explosives in complex matrix samples

[0058] In recent years, terrorist activities carried out by terrorists using explosives have shown an increasing trend around the world. At present, the demand for new explosives detection technology is increasing all over the world, especially for the in-situ, direct, fast, sensitive, highly selective, online and non-destructive detection of trace explosives in complex samples. At the same time, explosives can enter the body through the respiratory system, digestive system and skin, thereby causing various toxicity to organisms (such as causing neurasthenia, blood phase changes, etc.) and becoming important environmental pollutants. Therefore, the research on in-situ rapid detection of explosives is of great significance. Conventional detection methods cannot detect non-nitro explosives (such as TATP) online. In the mass spectrometry detection method, the commonly used electrospray ionization (ESI) and ...

example 3

[0062] Example 3: Detection of biological macromolecules

[0063] Mass spectrometry is widely used in the field of life sciences. Mass spectrometry has the advantages of high detection sensitivity and fast analysis speed. The detection process of biological macromolecules usually requires sample collection, separation and enrichment, etc. to be analyzed by LC-MS.

[0064] Test items: methanol solution containing lysozyme; aqueous solution containing blood

[0065]Detected components: lysozyme, myoglobin

[0066] Detection process: press the atmospheric pressure extraction chemical ionization source of the present invention Figure 1c It indicates that the installation is completed, and the parameters are adjusted: a=10mm, b=10mm, α=60°, β=80°, the reagent is methanol water acetic acid mixture (1:1:0.1%, volume ratio), flow rate 0.5μL / min, the carrier gas is nitrogen, the flow rate is 20psi, the high voltage is a positive voltage of 3.5kV, and the above-mentioned detection...

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Abstract

The utility model relates to a normal pressure chemical extraction ionization source, equipped with an ionization pipe and a sample pipe. The ionization pipe and the sample pipe are aslant arranged within an included angle and a distance, and the ports of the ionization pipe and the sample pipe point an ionization area jointly. The sample pipe comprises a sample inlet pipe and a sample carrying gas pipe, a gas or liquid sample is guided in the sample inlet pipe or the sample inlet pipe is communicated with a sample eduction pipe of a neutral desorbing device. The method of utilizing the normal pressure chemical extraction ionization source of the utility model comprises the steps of using a sample flow educed from the sample pipe and an ion flow educed from the ionization pipe to impact with each other to occur the extraction ionization, and then carrying out a mass spectrometry. The normal pressure chemical extraction ionization source is especially suitable for the real-time rapid analysis of complicated samples, such as biological sample, food, drugs, environmental sample, etc.

Description

technical field [0001] The invention belongs to the field of mass spectrometry and relates to an atmospheric pressure mass spectrometry ionization source of a mass spectrometer, in particular to an atmospheric pressure chemical extraction ionization source and an atmospheric pressure chemical extraction ionization mass spectrometry analysis method formed by applying it to mass spectrometry. Background technique [0002] Mass spectrometry is one of the most important methods in the field of analysis. With the development of science and technology, mass spectrometry not only plays an important role in routine chemical analysis, but also gradually becomes a popular field in life sciences, homeland security, food safety, clinical medical testing and space technology. one of the main methods. Subsequently, the ionization sources used in mass spectrometry have also been developed rapidly, and various new ion sources and new technologies are constantly emerging. In-situ, real-time...

Claims

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Application Information

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IPC IPC(8): H01J49/12G01N27/68
Inventor 陈焕文胡斌张兴磊欧阳永中肖赛金韩京
Owner EAST CHINA UNIV OF TECH
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