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A kind of patchouli oil microcapsules and its preparation method and application

A technology of patchouli oil and microcapsules, which is applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of low drug efficacy, prolonged efficacy, poor stability, etc., to eliminate strong odor, prolong efficacy, Antibacterial enhanced effect

Inactive Publication Date: 2011-12-14
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to overcome the defects of existing patchouli oil products such as poor stability, low drug efficacy and narrow use, the primary purpose of the present invention is a patchouli oil microcapsule, which has a good drug slow-release function and can be used for a long time. Preserve the active ingredients of patchouli oil to prolong the efficacy

Method used

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  • A kind of patchouli oil microcapsules and its preparation method and application
  • A kind of patchouli oil microcapsules and its preparation method and application
  • A kind of patchouli oil microcapsules and its preparation method and application

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Embodiment 1

[0051] A preparation method of patchouli oil microcapsules, comprising the following steps:

[0052] 1) Dissolve 1g of chitosan in 60mL of 1% (mass fraction) acetic acid solution, adjust the pH to 8, let stand overnight, filter with suction, put the filter cake in a constant temperature water bath at 75°C, add 30mL of 4g 2,3- After reacting the isopropanol solution of epoxypropyltrimethylammonium chloride for 8 hours, precipitate with absolute ethanol, wash, filter with suction, and dry to obtain chitosan quaternary ammonium salt, which is set aside.

[0053] 2) 0.5g chitosan, 0.5g chitosan quaternary ammonium salt are dissolved in 100mL 1% (mass fraction) acetic acid solution, are mixed with chitosan, chitosan quaternary ammonium salt compound solution that total concentration is 1% spare.

[0054] 3) Dissolve 1.5g of gum arabic in 100mL of 40°C distilled water to prepare a gum arabic solution with a concentration of 1.5%; add 0.6g of Span-80 and 1.25g of patchouli oil to th...

Embodiment 2

[0063] A preparation method of patchouli oil microcapsules, comprising the following steps:

[0064] 1) Dissolve 1g of chitosan in 60mL of 1% (mass fraction) acetic acid solution, adjust the pH to 8, let stand overnight, filter with suction, put the filter cake in a constant temperature water bath at 75°C, add 30mL of 4g 2,3- After reacting the isopropanol solution of epoxypropyltrimethylammonium chloride for 8 hours, precipitate with absolute ethanol, wash, filter with suction, and dry to obtain chitosan quaternary ammonium salt, which is set aside.

[0065] 2) Dissolve 0.4g chitosan and 0.6g chitosan quaternary ammonium salt in 100mL1% (mass fraction) acetic acid solution, and prepare chitosan and chitosan quaternary ammonium salt complex solution with a total concentration of 1%. .

[0066] 3) Dissolve 1g of gum arabic in 100mL of 40°C distilled water to prepare a gum arabic solution with a concentration of 1%; add 1g of Tween-80 to the gum arabic solution and mix well, th...

Embodiment 3

[0075] A preparation method of patchouli oil microcapsules, comprising the following steps:

[0076] 1) Dissolve 1g of chitosan in 60mL of 1% (mass fraction) acetic acid solution, adjust the pH to 8, let stand overnight, filter with suction, put the filter cake in a constant temperature water bath at 75°C, add 30mL of 4g 2,3- After reacting the isopropanol solution of epoxypropyltrimethylammonium chloride for 8 hours, precipitate with absolute ethanol, wash, filter with suction, and dry to obtain chitosan quaternary ammonium salt, which is set aside.

[0077] 2) Dissolve 0.4g chitosan and 0.6g chitosan quaternary ammonium salt in 100mL1% (mass fraction) acetic acid solution, and prepare chitosan and chitosan quaternary ammonium salt complex solution with a total concentration of 1%. .

[0078] 3) Dissolve 2g of gum arabic in 100mL of 30°C distilled water to prepare a gum arabic solution with a concentration of 2%; add 0.4g of Span-80 and 0.4g of polyethylene glycol-600 to the...

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Abstract

The invention discloses patchouli oil microcapsules and a preparation method and application thereof. The patchouli oil microcapsules are prepared by a complex coacervation method and are in a spherical shape, the grain diameter is between 3 and 15 micrometers, the medicine-carrying dose is up to 52.6 percent, and a mass ratio of core materials to wall materials is 1:(0.5-2); the core materials are patchouli oil, and the wall materials consist of a chitosan composition and Arabic gum in a mass ratio of 1:(1-3); and the chitosan composition consists of chitosan and chitosan quaternary ammoniumsalt in a mass ratio of 1:(1-3). The patchouli oil microcapsules have good medicine sustained-release effect, and can store the patchouli oil serving as active ingredients for a long time, prolong the medicinal effect and overcome the defects of poor stability, small utilization degree of the medicinal effect, narrow application and the like of the conventional patchouli oil product.

Description

technical field [0001] The invention belongs to the field of medicament production, and in particular relates to patchouli oil microcapsules and a preparation method and application thereof. Background technique [0002] Microcapsule technology is a protective technology that uses film-forming materials to encapsulate some reactive, sensitive or volatile liquids or solids to form tiny particles. Film-forming materials are generally called wall materials, which can be natural or synthetic. Natural substances such as chitosan, gum arabic, gelatin or sodium alginate, etc., are widely used as microcapsule walls because of their non-toxic, stable, biodegradable, good biocompatibility, good film-forming properties, etc. material. The encapsulated material is called the core material and can be a liquid, gas or solid substance. [0003] The main advantages of microcapsule technology are: (1) liquid state is transformed into solid state: when the liquid substance is microencapsul...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/50A61K47/36A61P31/04
Inventor 杨卓鸿胡洋李颖周华俊吴鸿
Owner SOUTH CHINA AGRI UNIV
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