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A composition for killing microorganisms

Active Publication Date: 2011-12-07
JIANGZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above-mentioned invention, or containing a large amount of alcohol substances, is used for long-term disinfection of hands and skin, which may lead to dryness, dehydration, redness, and chapping of the skin, and puts forward higher requirements for the transportation and storage of disinfection products; or the bactericidal effect Generally, it takes a long time to achieve or cannot achieve the ability to quickly kill bacteria and viruses equivalent to the composition of the present invention; or the formula has too many ingredients, the preparation process is cumbersome, and the process is complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prepare the disinfectant according to the following steps: Add 40L of hot purified water into a stainless steel bucket, weigh in 1kg of hypromellose and stir until transparent and clear. Add 200L of purified water into the preparation tank, add bronopol 0.3kg, 20% polyhexamethylene biguanide hydrochloride aqueous solution 15kg, 95% ethanol (volume ratio, converted to mass ratio is 92.3%, the same below) under stirring ) 440kg, isopropanol 39kg, glycerin 10kg, hypromellose solution, stop stirring after 5-10 minutes after adding, add purified water to 1000L scale, and continue stirring for 15 minutes. Subpackage after inspection and passing.

[0034] Among them, glycerin has the effect of emollient and skin care, can slow down the stimulation of alcohol solvents to the skin, and can also prolong the drying time and enhance the antibacterial effect; hydroxypropyl methylcellulose can make the disinfectant form a film on the surface of the skin and articles, Prolong the antib...

Embodiment 2

[0039] The preparation method of the disinfectant composition is the same as that of Example 1, and the prepared disinfectant solution is absorbed in the non-woven fabric as a wet wipe additive solution to make sanitary wet wipes.

[0040] After testing, under the condition of 20°C±1°C, the sanitary wet wipes have an average killing rate of 100% on Escherichia coli and Staphylococcus aureus, and have an average killing rate of 100% on Staphylococcus aureus. The average killing rate of Monomonas is 100%, the average killing rate of hemolytic streptococcus is 99.94%, the average killing rate of Candida albicans is 99.91%, and the average killing rate of influenza virus is > 3.00, the inactivation logarithmic value of HIV virus > 3.00.

[0041] Hand disinfection field test: After 30 person-time repeated tests, the sanitation wipes act for 1 minute, and the average log value of killing natural bacteria on the surface of the hand is > 1.00.

[0042] Escherichia coli simulated on-s...

Embodiment 3

[0045] Prepare the product according to the following steps: add 40L of hot purified water into a stainless steel bucket, weigh in 1kg of hypromellose and stir until transparent and clear. Add 200L of purified water into the preparation tank, add bronopol 0.3kg, 20% polyhexamethylene biguanide hydrochloride aqueous solution 5kg, 95% ethanol 258kg, isopropanol 9kg, glycerin 10kg, hypromellose Add plain solution, stir for 5-10 minutes after adding, stop stirring, add purified water to 1000L mark, and continue stirring for 15 minutes. Subpackage after inspection and passing.

[0046] The prepared product can also be used as an additive liquid for wet wipes to be absorbed in non-woven fabrics to make wet wipes.

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PUM

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Abstract

The invention relates to a composition for killing microorganisms. The composition is utilized mainly for hygienic hand disinfection, surgical hand disinfection, skin and mucosa disinfection and killing of microorganisms on object surfaces. The composition adopts poly(hexamethylene biguanide) hydrochloride and ethanol as main active ingredients for sterilization and isopropanol as a combination sterilization synergist, wherein ethanol concentration is in a range of 238 to 467 g / L, poly(hexamethylene biguanide) hydrochloride concentration is in a range of 0.01 to 15 g / L and isopropanol concentration is in a range of 9 to 54 g / L. According to needs, the composition can be added with a humectant, a stabilizer, a thickener and the like to be prepared into different forms of preparations. The composition has the advantages of good sterilization effects, fast onset, no need of washing, high stability, reduction of stimulation effects of products on skin, and favorable functions of moisturizing and protecting skin.

Description

technical field [0001] The present invention relates to a composition that can be used for hands, skin, mucous membranes, and the surface of articles including eating and drinking utensils, which can be washed away, quickly and efficiently kills microorganisms. Background technique [0002] Due to the aggravation of global warming and environmental pollution, the mutation of pathogenic microorganisms is accelerating; the abuse of various antibiotics and antiviral drugs, viruses immune to antibiotics and antiviral drugs, and the emergence of highly pathogenic and highly infectious pathogenic microorganisms The emergence is also accelerating. To deal with and control the outbreak and prevalence of infectious diseases caused by pathogenic microorganisms, it is necessary to control the source of infection, cut off the transmission route and protect the susceptible population. Among them, cutting off the transmission route is an important safe and reliable means. [0003] Differe...

Claims

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Application Information

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IPC IPC(8): A01N47/44A01N31/02A61K31/155A61K31/045A01P3/00A01P1/00A61P31/02A61P31/00A61L2/18A61L2/22A61L101/46A61L101/34A61L101/50
Inventor 钟虹光易敏之张文福陈芳夏春保卢建中李诒光马莉
Owner JIANGZHONG PHARMA
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