Preparation method of technical grade kasumin

A kasugamycin and carrier technology, which is applied in the field of kasugamycin technical preparation, can solve problems such as low yield of the raw medicine, achieve a simple and easy method, save resin de-impurification and deammonium, and a simple and easy production process Effect

Active Publication Date: 2011-11-23
陕西麦可罗生物科技有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0023] In the process of preparing the original drug of kasugamycin from the fermented filtrate, the process of resin de-impurity removal and de-ammonium removal is omitted, and the carrier is added to the filtrate to make pulp and then spray-dried. The defect of low yield has overcome the melting and sticky wall caused by direct spray drying without resin de-impurity, and the yield of kasugamycin has been successfully improved, and the mass percentage of kasugamycin can reach 4%-63.5%.

Method used

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  • Preparation method of technical grade kasumin
  • Preparation method of technical grade kasumin
  • Preparation method of technical grade kasumin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Streptomyces aureus fermentation broth was filtered to remove mycelia, and the pH value of the filtrate was adjusted to 3.5 with hydrochloric acid. The vacuum film concentrator concentrated the filtrate to make the content of kasugamycin 3.0%. When concentrating, the vacuum degree was -0.09Mpa and the temperature was 70°C , weighing kasugamycin fermentation filtrate 1000kg, kaolin 10kg. First add the above-mentioned kasugamycin concentrated filtrate in the open stirred tank, then start stirring, and control the rotating speed to be 50r / min. Add kaolin to the filtrate, and evenly add kaolin at a speed of 1 kg per minute under the condition of the paddle rotation speed of 50 r / min to make a slurry. The slurry enters the preheated spray drying tower for spray drying, and the temperature of the air inlet is adjusted to maintain the temperature inside the tower at 95°C during spray drying. After spray drying, the powder collected by the spray drying tower collector is off-w...

Embodiment 2

[0049]Streptomyces aureus fermented liquid was filtered to remove mycelia, and the pH value of the filtrate was adjusted to 2 with hydrochloric acid, and the vacuum film concentrator concentrated the filtrate so that the content of kasugamycin was 1.5%. When concentrating, the vacuum degree was -0.09Mpa, and the temperature was 50°C , weighing kasugamycin fermentation filtrate 1000kg, diatomaceous earth 50kg. First add the above-mentioned kasugamycin concentrated filtrate in an open stirred tank. Then start stirring, and the control speed is 70r / min. Diatomite was added to the filtrate, and diatomite was evenly added at a speed of 1 kg per minute under the condition of the paddle rotation speed of 70 r / min to form a slurry. The slurry enters the preheated spray drying tower for spray drying, and the temperature of the air inlet is adjusted to maintain the temperature inside the tower at 95°C during spray drying. After spray drying, the powder collected by the spray drying to...

Embodiment 3

[0051] Streptomyces aureus fermented liquid was filtered to remove mycelia, and the pH value of the filtrate was adjusted to 2 with hydrochloric acid. The vacuum film concentrator concentrated the filtrate so that the content of kasugamycin was 2.0%, and the vacuum degree was -0.09Mpa during concentration, and the temperature was 70°C , weighing kasugamycin fermentation filtrate 1000kg, diatomaceous earth 30kg. First add the above-mentioned kasugamycin concentrated filtrate in an open stirred tank. Then start stirring, and the control speed is 70r / min. Diatomite was added to the filtrate, and diatomite was evenly added at a speed of 1 kg per minute under the condition of the paddle rotation speed of 70 r / min to form a slurry. The slurry enters the preheated spray drying tower for spray drying, and the temperature of the air inlet is adjusted to maintain the temperature inside the tower at 95°C during spray drying. After spray drying, the powder collected by the spray drying ...

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Abstract

The invention provides a preparation method of technical grade kasumin, which comprises the following steps: filtering a Streptomyces ricroaureus fermentation liquid to remove hyphae, treating the filtrate with hydrochloric acid to regulate the pH value to 2-7, concentrating the filtrate, adding a carrier into the filtrate, pulping under a paddle stirring condition, and carrying out spray drying. By omitting resin impurity removal, ammonium removal and other steps, and carrying out spray drying after adding the carrier into the filtrate and pulping, the method overcomes the defect of low technical grade kasumin yield caused by the resin impurity removal process, and avoids the melting and bonding caused by direct spray drying without resin impurity removal, thereby successfully improving the kasumin yield. Because of the adsorption and dilution effects of the carrier, the preparation method ensures that the product subjected to spray drying has fine fluidity; dry and uniform powder can be formed, and is beneficial to the subsequent preparation; and the production process is simple and practicable.

Description

Technical field: [0001] The invention belongs to the field of microorganism-derived biological fungicides, and in particular relates to a preparation method of a kasugamycin original drug. Background technique: [0002] Kasugamycin, also known as Kasugamycin, Jiashoumi, Jiaruinong, etc., is an aminoglycoside produced by an actinomycete isolated from the soil of Kasuga Shrine in Nara Prefecture, Japan in April 1963 Antibiotics produced by Streptomyces Kasugaensis. The Institute of Microbiology of the Chinese Academy of Sciences successfully developed it in 1970 and named it Kasugamycin, which was later confirmed to belong to the same antibiotic as the "add rice" produced in Japan. Kasugamycin is an antibiotic used both in agriculture and medicine. As an agricultural fungicide, since its launch in 1966, kasugamycin preparations have been widely used in crops and control objects due to their outstanding advantages such as low toxicity, high efficiency and strong systemic perm...

Claims

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Application Information

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IPC IPC(8): C07H15/207C07H1/08A01P3/00
Inventor 李蒲民杨宏勃颜瑞莉
Owner 陕西麦可罗生物科技有限公司
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