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Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia

A technology of osteoporosis and traditional Chinese medicine, which is applied in the direction of medical preparations containing active ingredients, non-central analgesics, antipyretics, etc., can solve the problems of stimulation and no significant effect of osteocalcin, and achieve the treatment of osteoporosis loosening, improving bone pain and joint pain

Inactive Publication Date: 2011-10-19
华夏先葆(北京)中药研究院有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

Zhang Tianlan et al. explored the regulation of epimedium flavonoid glycosides and their metabolites on bone formation and bone resorption, and found that epimedium flavonoid glycosides and their metabolites had a significant stimulating effect on the proliferation of rat osteoblasts, and It can promote the synthesis and secretion of alkaline phosphatase in osteoblasts, but has no significant effect on the late differentiation index of osteoblasts, osteocalcin

Method used

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  • Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia
  • Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia
  • Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: The extract of epimedium and salvia miltiorrhiza is prepared by decocting

[0019] Preparation of Epimedium extract: Take 2000g of Epimedium, add 8 times the weight of the medicinal material to extract twice, extract for 2.0 and 1.5 hours respectively, filter, combine the extracts, concentrate under reduced pressure into an aqueous solution of 1g crude drug / mL, Dry under reduced pressure, pulverize, and pass through a 100-mesh sieve to obtain a brown-yellow Epimedium extract with a weight of 66 g and an icariin content of 5.0%.

[0020] Preparation of Salvia miltiorrhiza extract: Take Danshen medicinal material and crush it into coarse powder 2000g, add water 8 times the weight of medicinal material and extract 3 times, extract for 2.0, 1.5, 1.5 hours respectively, filter, combine extracts, concentrate under reduced pressure to 1g crude drug / mL The aqueous solution is dried under reduced pressure, pulverized, and passed through a 100-mesh sieve to obtain t...

Embodiment 2

[0021] Example 2 Tablet:

[0022]

[0023]

[0024] The above raw and auxiliary materials are made into 1000 pieces (1.0g / piece) in total

Embodiment 3

[0025] Example 3 Culture of human osteoblasts

[0026] A method of directional induction of human bone marrow stromal stem cells into osteoblasts was adopted. Human bone marrow was obtained from a spinal surgery patient without metabolic bone disease. With the consent of the patient before the operation, when taking the ilium bone graft during the operation, about 4ml of the bone marrow was aspirated at the wound with a bone needle, centrifuged and inoculated in a 75cm In the culture flask, half of the medium was changed after 5 days. After the cells were completely attached to the wall and fused, they were trypsinized, passaged, and the induction medium was changed to continue the culture. Induction medium composition: DMEM high-glucose medium containing 10% fetal bovine serum was added with dexamethasone, ascorbic acid and β-sodium glycerophosphate, the final concentrations were 10-8mol respectively -1 , 50ug.ml -1 , 10mmol.L -1 .The 3rd and 4th passage cells induced by t...

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Abstract

The invention relates to a Chinese medicine preparation, particularly a Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia. The Chinese medicine preparation contains epimedium extract, radix salviae miltiorrhizae extract, D-glucosamine hydrochloride, biological calcium carbonate (oyster calcium), collagen hydrolysate, chondroitin sulfate and other active ingredients, wherein the D-glucosamine hydrochloride can obviously promote the proliferation and differentiation actions of the epimedium extract and radix salviae miltiorrhizae extract on osteoblasts. By combining the traditional Chinese medicine theory and the modern medicine research, the preparation tonifies the liver and kidney, strengthens the kidney and bone, promotes the bloodcirculation, dredges the collaterals and directly supplements calcium and collagen in a biological way, so that the kidney-qi is sufficient, and the bone is tonified, thereby improving ostealgia and arthralgia, enhancing the quality of life in the turn of life, and further performing the functions of increasing bone density and improving osteoporosis and arthralgia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, especially a traditional Chinese medicine preparation which can improve osteoporosis, increase bone density, and relieve joint pain. The Chinese medicine preparation contains Epimedium extract, Salvia miltiorrhiza extract, biological calcium carbonate (oyster calcium), Active ingredients of hydrolyzed collagen, D-glucosamine hydrochloride and chondroitin sulfate. Background technique [0002] As the population ages and the aging population continues to increase, osteoporosis has seriously threatened the health of middle-aged and elderly people. Osteoporosis is known as the "silent killer". Statistics from WHO show that: There are more than 200 million people with porosis, and the annual cost of treatment and hospitalization is as high as 25 billion US dollars. According to the "Osteoporosis China White Paper 2008" issued by the China Health Promotion Foundation, the survey estimated ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P19/02A61P19/08A61P19/10A61P29/00A61K31/7008
Inventor 高艳慧
Owner 华夏先葆(北京)中药研究院有限公司
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