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Polypeptide donkey-hide gelatine dextran freeze-drying preparation and preparing process thereof

A technology of freeze-dried preparations and preparation processes, which is applied in the field of medicine, can solve problems affecting the quality of preparations, degradation and precipitation, etc., and achieve scientific and reasonable preparations with good stability

Inactive Publication Date: 2011-10-12
JIANGSU JIANZHONG INVESTMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] CN101190236A discloses a kind of donkey skin donkey-hide gelatin injection instead of plasma and its preparation method, but because donkey skin donkey-hide gelatin belongs to a kind of gelatin, gelatin injection will be degraded and precipitated for a long time, affecting the quality of the preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Select healthy and disease-free donkeys for cleaning, slaughtering, skinning, dehairing, and degreasing, soak in 2% sodium carbonate solution for 5 minutes, clean, decoct, concentrate, filter and separate, remove a small amount of fat on the surface and sediment at the bottom, and further Concentrate and dry into raw gum, dilute the raw gum with water, centrifuge, take the supernatant and refine it with cation exchange resin, filter to remove impurities, vacuum dry, and pack to obtain the polypeptide donkey skin glue.

[0021] Dissolve 0.025g soybean lecithin in 0.025g Solutol? HS-15, dissolve with 9L water for injection, add 250g polypeptide donkey skin glue, 62.5g sodium chloride, stir to dissolve, add activated carbon to boil, centrifuge, adjust pH value to 7-8 , filtered, added water for injection to 10L, sterile filtered, subpackaged, and freeze-dried to obtain the polypeptide donkey skin glue instead of plasma freeze-dried preparation of the present invention. Aft...

Embodiment 2

[0023] Select healthy and disease-free donkeys for cleaning, slaughtering, skinning, dehairing, and degreasing, soak in 2% sodium carbonate solution for 5 minutes, clean, decoct, concentrate, filter and separate, remove a small amount of fat on the surface and sediment at the bottom, and further Concentrate and dry into raw gum, dilute the raw gum with water, centrifuge, take the supernatant and refine it with cation exchange resin, filter to remove impurities, vacuum dry, and pack to obtain the polypeptide donkey skin glue.

[0024] Dissolve 0.25 soybean lecithin in 0.125g Solutol? HS-15, dissolve in 9L water for injection, add 250g polypeptide donkey skin glue, 70g sodium chloride, dissolve in appropriate amount of water for injection, add activated carbon to boil, centrifuge, and adjust the pH value to 7~ 8. Filtrate, add water for injection to 10L, filter aseptically, subpackage, and freeze-dry to obtain the freeze-dried preparation of conventional polypeptide donkey skin g...

Embodiment 3

[0026] Select healthy and disease-free donkeys for cleaning, slaughtering, skinning, dehairing, and degreasing, soak in 2% sodium carbonate solution for 5 minutes, clean, decoct, concentrate, filter and separate, remove a small amount of fat on the surface and sediment at the bottom, and further Concentrate and dry into raw gum, dilute the raw gum with water, centrifuge, take the supernatant and refine it with cation exchange resin, filter to remove impurities, vacuum dry, and pack to obtain the polypeptide donkey skin glue.

[0027] Dissolve 12.5 g of soybean lecithin in 12.5 g of Solutol? HS-15, dissolve in 9 L of water for injection, add 250 g of polypeptide donkey skin glue, 70 g of sodium chloride and dissolve in an appropriate amount of water for injection, adjust the pH value to 6.5, add activated carbon to boil, centrifuge, Adjust the pH value to 7-8, filter, add water for injection to 10L, subpackage, and sterilize by autoclaving at 115°C to obtain Polypeptide Donkey S...

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PUM

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Abstract

The invention relates to a polypeptide donkey-hide gelatine dextran freeze-drying preparation and a preparing process thereof, belonging to the technical field of medicines. The polypeptide donkey-hide gelatine dextran freeze-drying preparation is characterized by comprising the components as follows: polypeptide donkey-hide gelatine, Solutol HS-15(polyglycol stearate 15, polyglycol-12-hydroxy stearate) and phospholipid. According to the invention, lots of screening and researches find that: the Solutol HS-15 and the phospholipid which are formed as micelles can solve the problem that the polypeptide donkey-hide gelatine dextran freeze-drying preparation placed for a long time cannot be dissolved completely in the case water is added for dissolution, and both the Solutol HS-15 and the phospholipid are very safe auxiliary materials for intravenous injection.

Description

technical field [0001] The invention relates to a freeze-dried preparation and process of polypeptide donkey skin glue instead of plasma, belonging to the technical field of medicine. Background technique [0002] As we all know, plasma is the liquid part of circulating blood, which is an aqueous solution containing serum proteins, inorganic salts, electrolytes, glucose and fibrinogen. In peacetime, especially during wartime, when the human body loses too much blood due to various reasons, plasma needs to be supplemented. The use of human blood plasma and blood products has become unsafe due to some blood-borne diseases such as hepatitis and AIDS. In addition, human blood sources are limited and expensive, so human blood sources alone cannot meet the needs of a large amount of blood. The development and development of plasma substitutes for non-human blood has become a matter of great concern and attention in the scientific and medical circles. [0003] Currently in clinic...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K9/19A61K47/34A61P7/08
Inventor 黄雄伟花亚光龚箭邹亚轩黄雄信
Owner JIANGSU JIANZHONG INVESTMENT
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