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Application of hydrogen-saturated normal saline in preparation of medicine for treating hyperlipidemia disease

A technology of normal saline and hyperlipidemia, which is applied in the field of medicine, can solve the problems of not finding endogenous specific clearance pathways, achieve good therapeutic advantages, facilitate drinking, and reduce the risk of side effects of drugs

Inactive Publication Date: 2011-10-12
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In July 2007, Ohsawa I and others reported in "Natural Medicine" that animals breathing 2% hydrogen can effectively scavenge free radicals and significantly improve cerebral ischemia-reperfusion injury. They used chemical reactions, cytology and other means to prove that hydrogen dissolved It can selectively neutralize hydroxyl radicals and nitrite anions in liquid, and the latter two are the most important mediators of oxidative damage. At present, no endogenous specific clearance pathway has been found in the body
But there is no report about the application of hydrogen-saturated normal saline in the preparation of medicines for the treatment of hyperlipidemia

Method used

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  • Application of hydrogen-saturated normal saline in preparation of medicine for treating hyperlipidemia disease
  • Application of hydrogen-saturated normal saline in preparation of medicine for treating hyperlipidemia disease
  • Application of hydrogen-saturated normal saline in preparation of medicine for treating hyperlipidemia disease

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Experimental program
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Embodiment 1

[0023] I. Materials and Methods

[0024] (1) Model establishment and grouping

[0025] Animals were adaptively fed for 1 week to establish models, and 8-week-old male golden hamsters (110-140 g) were fed with high-fat diet (15% lard and 0.2% cholesterol) in addition to the normal control group. Blood was collected from the canthus to detect serum total cholesterol TC content. Taking into account the TC level, they were randomly divided into 4 groups according to body weight, namely model group (peritoneal injection of normal saline group), H 2 Low dose group (1 ml / kg / d), H 2 Middle dose group (2.5 ml / kg / d) and H 2 High dose group (5 ml / kg / d), 10 rats in each group. Normal saline or hydrogen-saturated saline were injected intraperitoneally for 4 weeks. In addition, 45 male 7-8 week old male apoE- / - mice were used in this experiment. At the age of 7-8 weeks, 24 apoE- / - mice fed a high-fat diet (15.8% fat and 1.25% cholesterol) were randomly divided into 3 groups, model gro...

Embodiment 2

[0054] Example 2 Preparation of hydrogen-containing oral liquid

[0055] Dissolve hydrogen in pure water under 0.4 MPa pressure for 6 hours to ensure that the hydrogen content in the oral liquid is slightly higher than 0.6 mmol / L, sterilize, store in an aluminum bag or aluminum tank without a cavity at normal pressure, and store at 4°C Store in the refrigerator.

Embodiment 3

[0056] Example 3 Preparation of hydrogen-containing oral liquid

[0057] Dissolve hydrogen in normal saline under the pressure of 0.4 MPa for 6 hours to ensure that the hydrogen content in the oral liquid is slightly higher than 0.6 mmol / L, sterilize, store in an aluminum bag or aluminum can without a cavity at normal pressure, and place in 4 ℃ refrigerator.

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Abstract

The invention relates to application of hydrogen-saturated normal saline in preparation of a medicine for treating a hyperlipidemia disease, and further provides application of a hydrogen-containing oral solution in preparation of a blood fat lowering health care product. The invention develops a new usage of the saturated normal saline, wherein a hyperlipidemia mesocricitus auratus model is employed; after the saturated normal saline is injected to an abdominal cavity for four weeks, blood is taken to detect content of plasma cholesterol; a result of experiments shows that a hydrogen treatment group is obviously reduced in both plasma TC (Total Cholesterol) and LDL-C (Low Density Lipoprotein Cholesterin). The hydrogen normal saline is simple in preparation, high in injection density, convenient for use and free from explosion risk, very low in cost, and free from side effects; and a result of animal experiments shows that the hydrogen-saturated normal saline has excellent treatment advantage and can greatly reduce side effect risk of hyperlipidemia patients and greatly lower medical cost.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of hydrogen saturated saline in the preparation of medicines for treating hyperlipidemia. Background technique [0002] A large number of basic research data and clinical practice have proved that hyperlipidemia, including hypercholesterolemia, is an important risk factor for stroke, coronary heart disease, myocardial infarction, and sudden cardiac death. In addition, hyperlipidemia is also an important risk factor for hypertension, impaired glucose tolerance, and diabetes. Hyperlipidemia can also lead to fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, fundus hemorrhage, blindness, peripheral vascular disease, claudication, hyperuricemia, etc. For the human body, hyperlipidemia is very harmful, and hyperlipidemia is the most dangerous (susceptible) factor among multiple factors that accelerate atherosclerosis. [0003] Currently, there are two main ...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P3/06A61K31/7004A61K33/00
Inventor 秦树存宋国华宗传龙田华
Owner TAISHAN MEDICAL UNIV
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