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Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction

A technology of indole and diketone is applied in the application field of indole-2,3-dione in the preparation of drugs for improving spermatogenesis disorders, and can solve the problems of human damage, dependence, difficult implementation and the like

Inactive Publication Date: 2011-10-12
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, surgical treatment is mainly aimed at patients with reproductive tract obstruction. Although the treatment of spermatogenesis disorder by Western medicine is sufficient in theory, it is extremely difficult to implement; artificial assisted reproductive technology is expensive and extremely risky. Most patients spend a lot of money, not only It has no effect, but cures problems, so not all patients can accept it
Drug treatment mainly uses sex hormones and gonadotropins. The spermatogenesis effect of these drugs is mainly through regulating the function of the hypothalamus-pituitary-gonad axis, adjusting and stimulating the spermatogenesis process of the human body. Large, easy to cause exogenous hormone dependence

Method used

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  • Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction
  • Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction
  • Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction

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Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of tablet

[0019] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add indole-2,3-dione, heat and dissolve at 60°C under the action of a magnetic stirrer, and recrystallize at room temperature to obtain needle-shaped orange red Crystallization, recrystallization 3 times according to the above operation. The crystals were pulverized and passed through an 80-mesh sieve, and 100 mg of indole-2,3-dione, 100 mg of lactose, and 295 mg of starch were weighed and mixed evenly, granulated by a wet method, dried, mixed with 5 mg of magnesium stearate after sizing, and compressed into tablets. into tablets each weighing 500 mg.

Embodiment 2

[0020] Embodiment 2: the preparation of capsule

[0021] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add indole-2,3-dione, heat and dissolve at 60°C under the action of a magnetic stirrer, and recrystallize at room temperature to obtain needle-shaped orange red Crystallization, recrystallization 3 times according to the above operation. The crystals were pulverized and passed through an 80-mesh sieve, and 100 mg of indole-2,3-dione, 100 mg of lactose, and 295 mg of starch were weighed and mixed evenly, and filled into capsules to make capsules with a net weight of 500 mg each.

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Abstract

The invention relates to application of 2,3-didetonindoline in preparation of a medicine for improving spermatogenesis dysfunction. The 2,3-didetonindoline is a natural product or an artificially synthesized product, is low in toxicity and less in side effect, and has excellent functions in improving spermatogenesis dysfunction and promoting procreation.

Description

technical field [0001] The invention relates to the application of indole-2, 3-dione (indole-2, 3-dione) in the preparation of medicine for improving spermatogenesis disorder. Background technique [0002] In recent years, due to environmental pollution, drug influence, and various electromagnetic waves and radiation influences, the decline in the quality and quantity of male sperm has become a common disease in andrology. According to statistics, 40% of infertile men have abnormal sperm quality, and the average number of human sperm decreases at a rate of 2%. The main manifestations of testicular spermatogenesis dysfunction are oligospermia, azoospermia and poor sperm motility. The treatment of male infertility caused by spermatogenesis mainly includes drug treatment, surgical treatment and artificial assisted reproductive technology. Among them, surgical treatment is mainly aimed at patients with reproductive tract obstruction. Although the treatment of spermatogenesis d...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P15/08
CPCA61K9/2018A61K9/2059A61K9/4858A61K9/4866A61K31/404A61P15/08
Inventor 岳旺石振艳刘占涛毛小红李静王园园
Owner QINGDAO UNIV
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