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Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction

A technology of indole and diketone, which is applied in the application field of indole-2,3-dione in the preparation of drugs for improving spermatogenesis disorders, and can solve the problems of treatment failure, high risk, and difficult implementation

Inactive Publication Date: 2012-07-04
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, surgical treatment is mainly aimed at patients with reproductive tract obstruction. Although the treatment of spermatogenesis disorder by Western medicine is sufficient in theory, it is extremely difficult to implement; artificial assisted reproductive technology is expensive and extremely risky. Most patients spend a lot of money, not only It has no effect, but cures problems, so not all patients can accept it
Drug treatment mainly uses sex hormones and gonadotropins. The spermatogenesis effect of these drugs is mainly through regulating the function of the hypothalamus-pituitary-gonad axis, adjusting and stimulating the spermatogenesis process of the human body. Large, easy to cause exogenous hormone dependence

Method used

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  • Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction
  • Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction
  • Application of 2,3-didetonindoline in preparation of medicine for improving spermatogenesis dysfunction

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Example 1: Preparation of tablets

[0019] Mix ultrapure water and absolute ethanol in a ratio of 1:5, add indole-2,3-dione, under the action of a magnetic stirrer, heat and dissolve at 60 °C, and recrystallize at room temperature to obtain needle-shaped orange red Crystallize, and recrystallize 3 times as above. The crystals were crushed and passed through an 80-mesh sieve, and 100 mg of indole-2,3-dione, 100 mg of lactose, and 295 mg of starch were weighed and mixed uniformly, granulated by wet method, dried, and mixed with 5 mg of magnesium stearate after granulation. into tablets each weighing 500 mg.

Embodiment 2

[0020] Example 2: Preparation of capsules

[0021] Mix ultrapure water and absolute ethanol in a ratio of 1:5, add indole-2,3-dione, under the action of a magnetic stirrer, heat and dissolve at 60 °C, and recrystallize at room temperature to obtain needle-shaped orange red Crystallize, and recrystallize 3 times as above. The crystals were pulverized and passed through an 80-mesh sieve, and 100 mg of indole-2,3-dione, 100 mg of lactose, and 295 mg of starch were weighed and mixed evenly, and the capsules were filled to prepare capsules with a pure weight of 500 mg each.

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Abstract

The invention relates to application of 2,3-didetonindoline in preparation of a medicine for improving spermatogenesis dysfunction. The 2,3-didetonindoline is a natural product or an artificially synthesized product, is low in toxicity and less in side effect, and has excellent functions in improving spermatogenesis dysfunction and promoting procreation.

Description

technical field [0001] The invention relates to the application of indole-2,3-dione (indole-2,3-dione) in the preparation of medicines for improving spermatogenesis disorders. Background technique [0002] In recent years, due to the influence of environmental pollution, drugs and various electromagnetic waves and radiation, the decline in the quality and quantity of male sperm has become a common disease in andrology. According to statistics, 40% of infertile men have abnormal sperm quality, and the average human sperm count declines at a rate of 2%. Testicular spermatogenesis dysfunction is mainly manifested as oligospermia, azoospermia and poor sperm motility. The treatment of male infertility caused by spermatogenesis disorder mainly includes drug treatment, surgical treatment and artificial assisted reproductive technology. Among them, surgical treatment is mainly aimed at patients with reproductive tract obstruction. Although Western medicine is adequate in theory fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/404A61P15/08
CPCA61K9/4866A61K31/00A61K9/2059A61K9/4858A61K9/2018A61K31/404A61P15/08
Inventor 岳旺石振艳刘占涛毛小红李静王园园
Owner QINGDAO UNIV
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