Ibuprofen microenema preparation and preparation method thereof
A kind of enema and miniature technology, applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problem of inconvenient dose adjustment of suppositories, achieve good clinical applicability and convenience, good rectal absorption characteristics, Ease of use
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Embodiment 1
[0019] The ibuprofen micro-enema prescription of the present embodiment comprises the following components by weight: sodium carboxymethylcellulose: 10g, ibuprofen 10, water-soluble hydroxypropyl-β-cyclodextrin 145 and paraben Ethyl ester 0.5.
[0020] The preparation method of the ibuprofen miniature enema prescription of the present embodiment may further comprise the steps:
[0021] a. Mix 10 g of ibuprofen and 145 g of water-soluble hydroxypropyl-β-cyclodextrin to make clathrate solution to form liquid A;
[0022] b. Dissolve 10 g of sodium carboxymethyl cellulose with 400 ml of purified water to form liquid B;
[0023] c. After dissolving 0.5 g of ethylparaben by weight in 100 ml of boiling water, add it into liquid A and mix evenly to form liquid C;
[0024] d. Add liquid C to liquid B and stir, add purified water to 1000ml, stir evenly, and put it into a 10ml glass bottle under 100,000-grade purification conditions.
[0025] For this example, replace 10g of sodium ca...
Embodiment 2
[0027] The ibuprofen micro-enema prescription of the present embodiment comprises the following components by weight: sodium carboxymethylcellulose 5, ibuprofen 5, water-soluble hydroxypropyl-β-cyclodextrin 75 and paraben Ester 0.5.
[0028] The preparation method of the ibuprofen miniature enema prescription of the present embodiment may further comprise the steps:
[0029] a. Mix 5 g of ibuprofen and 75 g of water-soluble hydroxypropyl-β-cyclodextrin to make clathrate solution to form liquid A;
[0030] b. Dissolve 5 g of sodium carboxymethyl cellulose with 400 ml of purified water to form liquid B;
[0031] c. After dissolving 0.5 g of ethylparaben by weight in 100 ml of boiling water, add it into liquid A and mix evenly to form liquid C;
[0032] d. Add liquid C to liquid B and stir, add purified water to 1000ml, stir evenly, and put it into a 10ml glass bottle under 100,000-grade purification conditions.
[0033] For this embodiment, 5g of sodium carboxymethylcellulose...
Embodiment 3
[0035] The ibuprofen micro-enema prescription of the present embodiment comprises the following components by weight: sodium carboxymethylcellulose 20, ibuprofen 8, water-soluble hydroxypropyl-β-cyclodextrin 285 and paraben Ester 0.5.
[0036] The preparation method of the ibuprofen miniature enema prescription of the present embodiment may further comprise the steps:
[0037] a. Mix 8 g of ibuprofen and 285 g of water-soluble hydroxypropyl-β-cyclodextrin to make clathrate solution to form liquid A;
[0038] b. Dissolve 20 g of sodium carboxymethyl cellulose with 400 ml of purified water to form liquid B;
[0039] c. After dissolving 0.5 g of ethylparaben by weight in 100 ml of boiling water, add it into liquid A and mix evenly to form liquid C;
[0040] d. Add liquid C to liquid B and stir, add purified water to 1000ml, stir evenly, and put it into a 10ml glass bottle under 100,000-grade purification conditions.
[0041] For this embodiment, 20g of sodium carboxymethylcell...
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