Bilayer tablet containing niacin and simvastatin, and preparation method thereof
A technology of simvastatin and double-layer tablets, applied in the field of pharmaceutical preparations, can solve the problems of high requirements for coating operation equipment and operation process, complex process, large fluctuation of simvastatin dosage, etc. Reliable release effect, simple equipment effect
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Embodiment 1
[0051] Niacin 500mg / Simvastatin 20mg double-layer tablet prescription (1000 tablets)
[0052] Niacin extended-release layer prescription:
[0053] Niacin 475g
[0054] Lactose 10g
[0055] 30% (g / L) ethyl cellulose aqueous suspension 40g
[0056] Hydroxypropyl methylcellulose (viscosity 100000cp) 100g
[0057] Stearic acid 30g
[0058] Simvastatin Layer Prescription:
[0059] Simvastatin 20g
[0060] Niacin 25g
[0061] Lactose 120g
[0062] Polysorbate 80 1g
[0063] Sodium carboxymethyl starch 4g
[0064] 5% (g / L) povidone k29 / 32 2g
[0065] 50% (L / L) ethanol aqueous solution
[0066] Stearic acid 0.5g
[0067] Coating Solution Prescription:
[0068] Hydroxypropyl methylcellulose (viscosity 50cp) 20g
[0069] Titanium dioxide 16g
[0071] Polysorbate 80 8g
[0072] Ethanol 400g
[0073] water 500g
[0074] Preparation:
[0075] First prepare the niacin sustained-release layer granules and simvastatin layer granules respectively, ...
Embodiment 2
[0090] Niacin 750mg / Simvastatin 20mg double-layer tablet prescription (1000 tablets)
[0091] Niacin extended-release layer prescription:
[0092] Niacin 710g
[0093] Lactose 10g
[0094] 30% (g / L) ethyl cellulose aqueous suspension 60g
[0095] Hydroxypropyl methylcellulose (viscosity 100000cp) 100g
[0096] Stearic acid 30g
[0097] Simvastatin Layer Prescription:
[0098] Simvastatin 20g
[0099] Niacin 40g
[0100] Lactose 120g
[0101] Polysorbate 80 1g
[0102] Sodium carboxymethyl starch 6g
[0103] 5% (g / L) povidone k29 / 32 3g
[0104] 50% (mL / mL) ethanol in water
[0105] Stearic acid 0.5g
[0106] Coating Solution Prescription:
[0107] Hydroxypropyl methylcellulose (viscosity 50cp) 20g
[0108] Titanium dioxide 16g
[0110] Polysorbate 80 8g
[0111] Ethanol 400g
[0112] water 500g
[0113] Preparation:
[0114] First prepare the niacin sustained-release layer granules and simvastatin layer granules respectively, then p...
Embodiment 3
[0129] Niacin 1000mg / Simvastatin 20mg double-layer prescription (1000 tablets)
[0130] Niacin extended-release layer prescription:
[0131] Niacin 950g
[0132] Lactose 10g
[0133] 30% (g / L) ethyl cellulose aqueous suspension 80g
[0134] Hydroxypropyl methylcellulose (viscosity 100000cp) 100g
[0135] Stearic acid 30g
[0136] Simvastatin Layer Prescription:
[0137] Simvastatin 20g
[0138] Niacin 50g
[0139] Lactose 120g
[0140] Polysorbate 80 1g
[0141] Carboxymethyl starch sodium 8g
[0142] 5% (g / L) povidone k29 / 32 4g
[0143] 50% (L / L) ethanol aqueous solution
[0144] Stearic acid 0.5g
[0145] Coating Solution Prescription:
[0146] Hydroxypropyl methylcellulose (viscosity 50cp) 20g
[0147] Titanium dioxide 16g
[0149] Polysorbate 80 8g
[0150] Ethanol 400g
[0151] water 500g
[0152] Preparation:
[0153] First prepare the niacin sustained-release layer granules and simvastatin granules respectively, then press t...
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