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Processing method for industrially producing rabbit brain powder

A processing method and technology of rabbit brain powder, which are applied in the processing field of industrialized production of rabbit brain powder, can solve the problems of loss of tissue factor activity, unfavorable mass production, small production scale and the like, and achieve a high activity, low cost and high production efficiency. Effect

Active Publication Date: 2013-05-15
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current preparation method of rabbit brain powder is as follows: take fresh rabbit brain, peel off the meninges and blood vessels, wash it with normal saline, cut it into pieces, then add an appropriate amount of acetone to grind, let the brain powder settle, and pour off the upper layer of acetone solution, Repeat this several times until the brain powder is off-white, then place the brain powder in a vacuum drying oven to dry, and completely evaporate the acetone solvent to obtain rabbit brain powder; In the process, it is easy to lose the activity of tissue factor in the rabbit brain powder, and the yield is extremely low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment one: a kind of processing method of industrialized production rabbit brain powder, its concrete processing process is:

[0015] Remove the skinned rabbit head, use large scissors to cut it from the lower part of the eye socket to the neck, and lift the skull from the back of the head, take out the rabbit brain, and then put the fresh rabbit brain in cold acetone at 0°C to control the temperature of the rabbit. The ratio of the weight of the brain to the volume of acetone is 1:1.5, soak for 10 minutes, remove the rabbit brain, remove the blood vessels and meninges in the rabbit brain with tweezers, and then add cold acetone at 0°C to the rabbit brain from which the blood vessels and meninges have been removed. Control the ratio of the weight of the rabbit brain to the volume of acetone to be 1:3, use a homogenizer to mix the rabbit brain and cold acetone at a speed of 500r / min for 4 minutes, and then put the rabbit brain evenly mixed with acetone into the centr...

Embodiment 2

[0016] Embodiment two: a kind of processing method of industrialized production rabbit brain powder, its concrete processing process is:

[0017] Remove the skinned rabbit head, use large scissors to cut it from the lower part of the eye socket to the neck, and lift the skull from the back of the head, take out the rabbit brain, and then put the fresh rabbit brain in cold acetone at 2°C to control the temperature of the rabbit. The ratio of the weight of the brain to the volume of acetone is 1:1.6, soak for 8 minutes, remove the rabbit brain, remove the blood vessels and meninges in the rabbit brain with tweezers, and then add cold acetone at 2°C to the rabbit brain from which the blood vessels and meninges have been removed. Control the ratio of the weight of the rabbit brain to the volume of acetone to be 1:3, use a homogenizer to mix the rabbit brain and cold acetone at a speed of 700r / min for 5 minutes, and then put the rabbit brain evenly mixed with acetone into the centri...

Embodiment 3

[0018] Embodiment three: a kind of processing method of industrialized production rabbit brain powder, its concrete processing process is:

[0019] Remove the skinned rabbit head, use large scissors to cut it from the lower part of the eye socket to the neck, and lift the skull from the back of the head, take out the rabbit brain, and then put the fresh rabbit brain in cold acetone at 1 °C to control the temperature of the rabbit. The ratio of the weight of the brain to the volume of acetone is 1:2, soak for 2 minutes, remove the rabbit brain, remove the blood vessels and meninges in the rabbit brain with tweezers, and then add cold acetone at 1°C to the rabbit brain from which the blood vessels and meninges have been removed. Control the ratio of the weight of the rabbit brain to the volume of acetone to be 1:4, use a homogenizer to mix the rabbit brain and cold acetone at a speed of 1000r / min for 2 minutes, and then put the rabbit brain evenly mixed with acetone into the cent...

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Abstract

The invention discloses a processing method for industrially producing rabbit brain powder. The method is characterized by comprising the following processes of: taking fresh rabbit brain, soaking the rabbit brain into cold acetone, fishing out the rabbit brain, removing blood vessels and meninges, adding the treated rabbit brain into the cold acetone, mixing the rabbit brain and the cold acetoneuniformly by using a homogenizer, performing centrifugation to remove the acetone solvent, and drying the rabbit brain powder. The method has the advantages that: because the traditional mortar for grinding is substituted by using the homogenizer, the activity of tissue factors in the rabbit brain is kept; the taken fresh rabbit brain is directly soaked into the cold acetone to substitute the traditional brine washing, so that the velocity of removing the blood vessels and the meninges in the rabbit brain is improved and the activity of the tissue factors is improved; the velocity of gas jet impact drying for rabbit brain powder protection with gas is improved by 2 to 3 times compared with the velocity of the traditional vacuum drying, and the rabbit brain powder is thinner, higher in activity and purer in color; and the whole method is high in production efficiency, and can realize industrialized large-scale production.

Description

technical field [0001] The invention relates to a processing method of rabbit brain powder, in particular to a processing method for industrial production of rabbit brain powder. Background technique [0002] Tissue factor is a membrane-bound lipid-dependent glycoprotein, which can form a complex with coagulation factor VII and significantly improve the activation ability of coagulation factor VII to factors X and IX. Tissue factor plays a hemostatic effect by activating the coagulation cascade reaction. Rabbit brain powder extracted with acetone is rich in tissue factor, so rabbit brain powder is widely used in medical clinical tests. [0003] The current preparation method of rabbit brain powder is as follows: take fresh rabbit brain, peel off the meninges and blood vessels, wash it with normal saline, cut it into pieces, then add an appropriate amount of acetone to grind, let the brain powder settle, and pour off the upper layer of acetone solution, Repeat this several...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/47
Inventor 徐嘉杰苏秀榕翁巧琴
Owner NINGBO UNIV
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