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Decumbent corydalis tuber vacuum freeze drying process and preparation process for decumbent corydalis tuber powder

A technology of drying process and preparation process, which is applied in the directions of medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc. Master the dosage and other issues to achieve the effect of retaining the efficacy and its active ingredients, promoting the modernization of traditional Chinese medicine, and saving traditional Chinese medicine resources

Active Publication Date: 2012-10-10
西藏求本生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets often affect the full absorption of the drug due to disintegration and slow dissolution of the drug, making it inconvenient to take for the elderly, children and patients with dysphagia.
Although liquid preparations are convenient to take, they have poor stability, inconvenient packaging, transportation and storage, and it is difficult to accurately grasp the dosage

Method used

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  • Decumbent corydalis tuber vacuum freeze drying process and preparation process for decumbent corydalis tuber powder
  • Decumbent corydalis tuber vacuum freeze drying process and preparation process for decumbent corydalis tuber powder
  • Decumbent corydalis tuber vacuum freeze drying process and preparation process for decumbent corydalis tuber powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Adopt vacuum freeze dryer to carry out summer without vacuum freeze-drying.

[0029] Such as figure 1 As shown, select fresh summer free raw materials, take out inferior quality and impurities, remove fibrous roots, and wash at a high concentration; pre-dry summer free to a water content of 90%, and then pack them into trays. The weight of the trays is 14kg / m 2 , thickness 2.5cm, pre-freeze at -30°C after gradually cooling down for 2 hours; then vacuumize the system until the absolute pressure of the system is 65Pa, start heating to 40°C-70°C, sublimation and drying for 18 hours; then keep the material temperature at 35°C, Make the water content below 2% before discharge.

[0030] Such as figure 2 As shown, after the above-mentioned steps, Xia Tian has passed through the grinding powder, and after passing through a 100-mesh sieve, the physical wall is broken. In a sealed and dry state, two supersonic airflows are used to impact the Xia Tian powder, and the wall break...

Embodiment 2

[0033]Adopt vacuum freeze dryer to carry out summer without vacuum freeze-drying.

[0034] Select summer free raw materials, take out inferior quality and impurities, remove fibrous roots, and wash at a high concentration; pre-dry summer free to a water content of 80%, and then pack them into trays. The weight of the trays is 12kg / m 2 , thickness 2cm, pre-freeze at -40°C after gradually cooling down for 2 hours; then vacuumize the system until the absolute pressure of the system is 70Pa, start heating to 50°C-70°C, sublimation and drying for 20 hours; then keep the material temperature at 40°C, so that Discharge after the water content reaches below 3%.

[0035] After the above-mentioned steps, the summer powder is crushed through a 100-mesh sieve, and the physical wall is broken. In a sealed and dry state, two supersonic airflows are used to impact the summer powder. The wall breaking rate reaches 98%. After the wall is broken, it will be dehumidified and packaged in a const...

Embodiment 3

[0037] Adopt vacuum freeze dryer to carry out summer without vacuum freeze-drying.

[0038] Select summer free raw materials, take out inferior quality and impurities, remove fibrous roots, and wash at a high concentration; pre-dry summer free to a water content of 70%, and then pack them into trays, and the weight of the trays is 10kg / m 2 , thickness 2cm, pre-freeze at -60°C after gradually cooling down for 3 hours; then vacuumize the system until the absolute pressure of the system is 75Pa, start heating to 60°C-70°C, sublimation and drying for 22 hours; then keep the material temperature at 45°C, so that Discharge after the water content reaches below 3%.

[0039] After the above-mentioned steps, the summer powder is crushed through a 100-mesh sieve, and the physical wall is broken. In a sealed and dry state, two supersonic airflows are used to impact the summer powder. The wall breaking rate reaches 98%. After the wall is broken, it will be dehumidified and packaged in a ...

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Abstract

The invention relates to a decumbent corydalis tuber vacuum freeze drying process and a preparation process for decumbent corydalis tuber powder. The decumbent corydalis tuber vacuum freeze drying process comprises the following steps of: 1) selecting fresh decumbent corydalis tuber raw materials, and removing poor-quality raw materials and impurities; 2) removing fibrous roots, and cleaning deeply; 3) pre-drying decumbent corydalis tuber until the moisture content is between 90 and 70 percent; 4) dishing the pre-dried decumbent corydalis tuber, cooling gradually for 2 to 3 hours, and pre-freezing at the temperature of between -20 and -60 DEG C, wherein the dishing weight is between 10 and 14 kg / m<2>, and the thickness is between 2 and 3 centimeters; 5) performing sublimation drying in the vacuum freeze drying process of the decumbent corydalis tuber, namely vacuumizing until the absolute pressure of a system is between 60 and 75 Pa, starting heating to the temperature of between 40 and 70 DEG C, and performing the sublimation drying for 15 to 24 hours; and 6) maintaining the temperature of materials to be between 20 and 50 DEG C, and discharging after the moisture content is below 3 percent. The decumbent corydalis tuber subjected to the vacuum freeze drying process keeps the pharmacodynamic ingredients of original medicaments and restores the performance of crude medicamentsto a maximum degree, and is small in administration dosage, higher in active ingredient content and more definite in curative effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a process for retaining medicinal active ingredients by vacuum freeze-drying of traditional Chinese medicine summer and a preparation process for summer powder. Background technique [0002] Summer Wu is the dry tuber of Corydalis decumbens (Thunb.) Pers. Excavate after emergence in spring or early summer, and remove stems, leaves and fibrous roots. This product is spherical, oblong or irregular block, with a length of 0.5-3cm and a diameter of 0.5-2.5cm; the surface is grayish yellow, dark green or dark brown, with tumor-like protrusions and inconspicuous fine wrinkles, and the top is blunt and round , stem scars can be seen, and there are light yellow dot-like leaf scars and fibrous root scars around; hard texture, yellow-white or yellow cross-section, granular or horny, and some are slightly powdery; slightly smelly, bitter taste; mainly prod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P1/16A61P7/02A61P9/06A61P9/12A61P25/08A61P29/00
Inventor 任燕应群芳
Owner 西藏求本生物科技发展有限公司
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