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Ultra high speed and high sensitivity DNA base sequence analysis system and analysis method for same

A base sequence and analysis system technology, which is applied in the field of system structure, can solve the problems of small number of bases, great difficulty, and long time consumption, and achieve the effect of simplifying analysis operations and preventing analysis errors

Inactive Publication Date: 2011-08-24
CHUNGBUK NAT UNIV IND ACADEMIC COOPERATION FOUND
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Problems solved by technology

However, these methods have disadvantages in that the number of bases analyzed per unit time is small, and it takes a long time for preparations such as replacing radioactive isotopes or dyes
In addition, not only the cost is high, but also environmental pollutants such as radioactive waste are discharged after the analysis is completed.
[0005] In addition, the length of DNA that can be analyzed is limited, and it is difficult to analyze several DNAs at the same time
[0006] At present, although various methods for analyzing the base sequence of deoxyribonucleic acid have been developed, there are problems in that the number of bases analyzed per unit time is small, and in the preparation work such as replacing radioactive isotopes or dyes, etc. takes a long time
In addition, not only the cost is high, but also environmental pollutants such as radioactive waste are discharged after the analysis is completed.
[0007] In addition, the length of DNA that can be analyzed is limited, and it is difficult to analyze several DNAs at the same time

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  • Ultra high speed and high sensitivity DNA base sequence analysis system and analysis method for same
  • Ultra high speed and high sensitivity DNA base sequence analysis system and analysis method for same

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Embodiment Construction

[0044] ( structure )

[0045] figure 1 is a structural diagram showing the structure of a single-electron transistor, figure 2 It is a circuit diagram schematically showing the structure of a single-electron transistor. figure 1 and figure 2 A single-electron transistor used in the detection unit of the present invention is schematically shown. like figure 1 and figure 2 As shown, the single-electron transistor is composed of the following components: a quantum dot QD with a size ranging from several nanometers to tens of nanometers; a source S that discharges electrons to the quantum dot QD; a drain D that flows electrons from the quantum dot S; The first grid G1 for adjusting the state of the quantum dot QD; and the second grid G2 required for coupling the probe to the quantum dot QD.

[0046] The single-electron transistor can be replaced by other components sensitive to charge response, such as quantum point contact (QPC), and in order to improve the response sp...

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Abstract

The present system relates to a system architecture that uses a single electron transistor (SET) to analyze base sequences of deoxyribonucleic acid (DNA) at ultra high speed in real time. DNA represents the entire body of genetic information and consists of nucleotide units. There are a total of four types of nucleotides, and each nucleotide consists of an identical pentose (deoxyribose), and four types of bases that differ in their phosphate groups (Adenine: A, Guanine: G, Cytosine: C, Thymine: T). A and G are purines having a bicyclic structure while C and T are pyrimidines having a monocyclic structure. Each has a different atomic arrangement, which signifies a different charge distribution from one another. Therefore, a system comprising a single electron transistor that is very sensitive to charges, a probe of a very small size that reacts to one nucleotide very effectively, and an extended gate that connects the SET with the probe, can be used to analyze DNA base sequences at ultra high speed in real time.

Description

technical field [0001] The present invention relates to a method and a system structure for analyzing the base sequence of deoxyribonucleic acid. More specifically, it relates to an analysis method and system configuration capable of analyzing a large amount of deoxyribonucleic acid base sequences in real time at ultrahigh speed compared with the analysis methods currently used. Background technique [0002] Deoxyribonucleic acid is the totality of genetic information, composed of nucleotide units. Proteins are synthesized according to the sequence of nucleotides recorded in deoxyribonucleic acid, and when a base sequence differs from the original base sequence, a different protein will be synthesized, causing serious problems. Therefore, from the viewpoint of disease prevention and treatment, it is very important and necessary to check whether the deoxyribonucleic acid has the correct nucleotide sequence. [0003] There are four types of nucleotides, each of which consist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/588B82Y15/00G01N33/48721C12Q1/6869B01L3/502761G01N27/414B82Y5/00G01N27/00Y10S436/806C12Q2565/631C12Q2565/629C12Q2565/607
Inventor 崔重范李钟真
Owner CHUNGBUK NAT UNIV IND ACADEMIC COOPERATION FOUND
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