Medicine composite used for curing endometriosis, preparation method and applications thereof

A technology for endometriosis and ectopic disease, applied in the field of medicine, can solve the problems of harming the physical and mental health of patients, large side effects, unsatisfactory treatment effect, etc., and achieve the effect of good treatment effect.

Active Publication Date: 2012-12-05
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Seriously endangering the physical and mental health of patients, it has attracted great attention from the medical community. Modern medicine mainly uses hormone drugs and surgical treatment, but the treatment effect is not ideal, it is easy to relapse, and the side effects are large, so it cannot be applied clinically.

Method used

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  • Medicine composite used for curing endometriosis, preparation method and applications thereof
  • Medicine composite used for curing endometriosis, preparation method and applications thereof
  • Medicine composite used for curing endometriosis, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The investigation of embodiment 1 extraction technology

[0016] Formulated by weight astragalus, sage vine, evodia, mugwort leaves, chuanxiong, zedoary, ground beetle, red peony, leech, Patrinia, dandelion, cork and honeysuckle (10:10:5:5:4:4:5: 5:5:10:10:5:10) Weigh 264g (4 parts) of medicinal materials, add 10 times the amount of 30%, 60%, 75%, 90% ethanol to soak for 30 minutes, heat and reflux extraction twice, each After 2 hours, the filtrates were combined and concentrated to 500ml. The sample solution was taken to pass through the microporous membrane, and the content of evodiamine was determined according to the proposed content determination method. Three parallel operations were performed. The results are shown in Table 1.

[0017] Table 1 Examination results of extraction solvents (n=3)

[0018]

[0019] It can be known from Table 1-6 that the content of Evodia rutaecarpa extracted with 75% ethanol is relatively high among the four extraction solvent...

Embodiment 2

[0034] The investigation of embodiment 2 purification process

[0035] Weigh 1000g of medicinal materials according to the formula described in Example 1, add 12 times the amount of 75% ethanol to reflux extraction for 3 times, each time for 2 hours, filter, combine the extracts, recover ethanol under reduced pressure to obtain alcohol extract I; D101 macroporous resin was applied to a part of solution I, and the effluent was eluted with water until the effluent was colorless, then eluted with 75% ethanol until the effluent was colorless, and then eluted with 90% ethanol until colorless, to obtain ethanol eluent II; Concentrate the alcohol extract Ⅰ to an appropriate amount (relative density is 1.02-1.05), centrifuge to obtain centrifugal precipitate Ⅲ and extract Ⅳ; put D101 macroporous resin on the extract Ⅳ, elute with water until the effluent is colorless, and then wash with Elute with 75% ethanol until the effluent is colorless, and then elute with 90% ethanol to obtain...

Embodiment 3

[0048] The investigation of embodiment 3 formula dosage forms

[0049] In the clinical application of this formula, enema is used after extraction, and the drug is closer to the treatment site, and the curative effect is better. Therefore, in combination with the clinical medication method and the best therapeutic effect, the rectal suppository is selected as the dosage form of this formula.

[0050] In order to ensure that the active ingredients in the extract are less damaged or damaged, the ethanol eluate is concentrated under reduced pressure. The extract is dried by vacuum drying.

[0051] Adopt hot-melt method to prepare suppository, its concrete method is as follows:

[0052] 1) The technological process of the hot melt method is: melting matrix - adding medicine (mixing) - injection molding - cooling - scraping - taking out - finished suppository.

[0053] 2) The screening of the matrix is ​​as follows: select three representative matrices of glycerin gelatin, PEG4...

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Abstract

The invention discloses a medicine composite used for curing endometriosis, a preparation method and applications thereof. The medicine composite comprises the following medicinal materials or extracts: radix astragali, caulis sargentodoxae, fructus evodiae, folium artemisiae argyi, ligusticum wallichii, rhizoma curcumae, ground beeltle, radix paeoniae rubra, leech, dahurian patrinia herb, dandelion, cortex phellodendri and caulis lonicerae; and in the formula, the medicine composite puts qi supporting first, takes the condition of promoting blood circulation and removing blood stasis as standard, treats both principal and secondary aspect of diseases, is utilized at low temperature and warm temperature, applies attacking and supplementing simultaneously, and has good curative effect for patients of abdominal mass, dysmenorrheal, infertility, abnormal menstruation and the like belonging to blood stasis in gynaecology.

Description

technical field [0001] The invention relates to a medicine, more specifically to a medicine combination, preparation method and application for treating endometriosis. technical background [0002] Endometriosis is a series of abnormal symptoms caused by the growth of endometrium in other parts of the body outside the uterine cavity. Ectopia is called ovarian cyst in the ovary, chocolate cyst in the pelvic cavity, and adenomyosis in the myometrium. Most patients are accompanied by uterine fibroids. [0003] Endometriosis is a chronic medical disease and one of the most common gynecological diseases. The disease generally develops slowly and has no special symptoms in the early stage. Sometimes it is like mild chronic pelvic inflammatory disease, and sometimes it will show recurrent labor pains. , but no obvious fever. Manifested as periodic lower abdominal pain, pain during sexual intercourse, and anal pain; menstrual flow increases in patients with menstrual disorders ade...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P15/00A61K35/62A61K35/64
Inventor 张小梅江兵梁旭明励娜杨荣平王宾豪
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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