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Medicine composite used for curing endometriosis, preparation method and applications thereof

A technology for endometriosis and ectopic disease, applied in the field of medicine, can solve the problems of harming the physical and mental health of patients, large side effects, unsatisfactory treatment effect, etc., and achieve the effect of good treatment effect.

Active Publication Date: 2011-07-27
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Seriously endangering the physical and mental health of patients, it has attracted great attention from the medical community. Modern medicine mainly uses hormone drugs and surgical treatment, but the treatment effect is not ideal, it is easy to relapse, and the side effects are large, so it cannot be applied clinically.

Method used

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  • Medicine composite used for curing endometriosis, preparation method and applications thereof
  • Medicine composite used for curing endometriosis, preparation method and applications thereof
  • Medicine composite used for curing endometriosis, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Examination of Example 1 Extracting process

[0016] According to the weight recipe, astragalus, big blood vine, dogwood, Ai leaf, Chuanxiong, Curcuma, earthworms, red peony, lequee, fringe grass, dandelion, coptard and ninja vine (10: 5: 4: 4: 5: 5: 5:5: 5: 10: 10: 5: 10) Weighing 264g of medicinal materials (4 parts), adding 10 times, 30%, 60%, 75%, and 90%of the ethanol for 30 minutes, and the heating back is extracted 2 times, each each, each time, each time, each time, each time, each time.Two hours, merged filter fluid and condensed to 500ml, which was obtained.The sample solution is used for microre filter membranes, and the content of Evodia is measured according to the proper content measurement method. 3 copies are operated in parallel. The results are shown in Table 1.

[0017] Table 1 Extract the results of soluble media examination (n = 3)

[0018]

[0019] It can be seen from Table 1-6 that the content of Evoda with 75 % of the 75 % of the solution of soluti...

Embodiment 2

[0034] Examination of Example 2 Pure Craftsmanship

[0035] According to the formula 1, the recipe is called 1000g of medicinal materials, and the ethanol returns with a 12 times 75%amount of ethanol returns to extract 3 times. 2 hours each time, filtering, merging extraction solution, reducing pressure recycling ethanolPart of the D101 large hole resin in part of the liquid Ⅰ, the water was washed until the flow was colorless, and 75%ethanol was eluted until the outflow of the outflow was colorless, and then the ethanol was eluted to the colorless liquid to obtain it.Take the alcohol -liquid Ⅰ to an appropriate amount (relative density is 1.02 ~ 1.05), centrifugal, get centrifugal precipitation Ⅲ and extract liquid IV;75%ethanol was eluted until the flow was colorless, and then the ethanol was eluted with 90%ethanol was eluted.

[0036] The above-mentioned Ⅰ-品 sample acts on endometriosis and observes the effect of the sample on the endometriosis of the uterine endometrium.

[00...

Embodiment 3

[0048] Examination of Example 3 Formulating Form

[0049] This formula is used in clinical use of extraction enema. The drug is closer to the treatment site, and the curative effect is better. Therefore, combined with clinical medication methods and the best treatment effect, the dosage form of the rectal thrombus is selected.

[0050] The specific method of preparation of hot -melt method is as follows:

[0051] 1) The process process of the hot-melt method is: melting matrix-plus human drug (mixed) -moaming-cooling-scraping-removing-finished suppositories.

[0052] 2) The screening of the matrix is: Choose Glycerin Plagiarity, PEG4000: PEG6000 (3: 5) and semi -synthetic fatty acid glycerin.The suppository, based on the appearance of the appearance, the time limit of the fusion, and the solubility of the discretion as the inspection indicator to determine the substrate of the formula of the formula described in the present invention.

[0053] Among them, in the clearing dish of t...

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Abstract

The invention discloses a medicine composite used for curing endometriosis, a preparation method and applications thereof. The medicine composite comprises the following medicinal materials or extracts: radix astragali, caulis sargentodoxae, fructus evodiae, folium artemisiae argyi, ligusticum wallichii, rhizoma curcumae, ground beeltle, radix paeoniae rubra, leech, dahurian patrinia herb, dandelion, cortex phellodendri and caulis lonicerae; and in the formula, the medicine composite puts qi supporting first, takes the condition of promoting blood circulation and removing blood stasis as standard, treats both principal and secondary aspect of diseases, is utilized at low temperature and warm temperature, applies attacking and supplementing simultaneously, and has good curative effect for patients of abdominal mass, dysmenorrheal, infertility, abnormal menstruation and the like belonging to blood stasis in gynaecology.

Description

Technical field [0001] The present invention involves a drug, and it is more specifically involved in the treatment of drug combinations, preparation methods and uses in treating endometriosis. technical background [0002] Endometriosis is a series of abnormal symptoms caused by the endometrium with growth function outside the body of the uterine cavity.Extrace The ovarian cysts are called ovarian cysts. Most of the pelvic cavity is chocolate cysts. In the uterine muscle layer, most patients are accompanied by uterine fibroids at the same time. [0003] Endometriosis is a major medical symptom and one of the most common gynecological diseases. The condition generally develops slowly. There is no special symptoms in the early stage. Sometimes it looks like mild chronic pelvic inflammatory disease., But there is no obvious fever.It is manifested as periodic lower abdomen pain, sexual intercourse pain, and anal permanent pain; patients with menstrual disorders increased menstrual f...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P15/00A61K35/62A61K35/64
Inventor 张小梅江兵梁旭明励娜杨荣平王宾豪
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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