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Biochemical oral liquid and preparation method thereof

An oral liquid and biochemical technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as simple and rough processes, inability to meet people's medication needs, and single dosage forms

Inactive Publication Date: 2011-07-06
SHANXI ZHENDONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Shenghua pills have been included in the drug standards of the Ministry of Health of the People's Republic of China, but the original dosage form is single, and the process is simple and rough, which is far from meeting people's drug needs

Method used

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  • Biochemical oral liquid and preparation method thereof
  • Biochemical oral liquid and preparation method thereof
  • Biochemical oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Take 246.15g of angelica, 92.31g of Chuanxiong, 30.77g of peach kernel, 15.38g of licorice, and 15.38g of dried ginger (fried charcoal) and grind them into coarse powder, add 8 times the amount of water to extract the volatile oil for 6 hours, reflux and extract twice, the first time Add 8 times the amount of water, the reflux time is 1.5 hours, and add 10 times the amount of 75% ethanol for the second time to reflux for 2 hours. Combine the distillation and the water extract after the first reflux, refrigerate for 24 hours, filter, and use the filtrate for later use; concentrate the alcohol extract after the second reflux until it has no alcohol smell, refrigerate for 24 hours, then filter, and use the filtrate for later use. Combine the above spare filtrates and concentrate to the extract with a relative density of 1.10-1.20 (60-70°C), add 200g of sucrose to the extract, boil to dissolve, add 10g of Tween-80, stir, cool to 70-80°C, add 1g of sorbic acid, stir evenly, ...

Embodiment 2

[0057] Take 197g of angelica, 74g of Chuanxiong, 25g of peach kernel, 12g of licorice, and 12g of dried ginger (fried charcoal) and grind them into coarse powder, add 8 times the amount of water to extract the volatile oil for 6 hours, reflux and extract twice, and add 8 times the amount for the first time water, the reflux time was 1.5 hours, and 10 times the amount of 75% ethanol was added for the second time to reflux for 2 hours. Combine the distillation and the water extract after the first reflux, refrigerate for 24 hours, filter, and use the filtrate for later use; concentrate the alcohol extract after the second reflux until it has no alcohol smell, refrigerate for 24 hours, then filter, and use the filtrate for later use. Combine the above spare filtrates and concentrate to the extract with a relative density of 1.10-1.20 (60-70°C), add 160g of sucrose to the extract, boil to dissolve, add 8g of Tween-80, stir, cool to 70-80°C, add 0.8g sorbic acid, stirred evenly, co...

Embodiment 3

[0059] Take 369g of angelica, 138g of chuanxiong, 46g of peach kernel, 23g of licorice, and 23g of dried ginger (fried charcoal) and grind them into coarse powder, add 8 times the amount of water to extract the volatile oil for 6 hours, reflux and extract twice, and add 8 times the amount for the first time water, reflux for 1.5 hours, add 10 times the amount of 75% ethanol for the second time and reflux for 2 hours. Combine the distillation and the water extract after the first reflux, refrigerate for 24 hours, filter, and use the filtrate for later use; concentrate the alcohol extract after the second reflux until it has no alcohol smell, refrigerate for 24 hours, then filter, and use the filtrate for later use. Combine the above spare filtrates and concentrate to the extract with a relative density of 1.10-1.20 (60-70°C), add 300g of sucrose to the extract, boil to dissolve, add 15g of Tween-80, stir, cool to 70-80°C, add 1.5g sorbic acid, stir evenly, cool to below 40°C, a...

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Abstract

The invention discloses biochemical oral liquid, which takes Chinese angelica, Szechuan lovage rhizome, peach seed, dried ginger and liquoric root as active pharmaceutical ingredients, the active pharmaceutical ingredients are prepared into liquid extract by adopting the modern process, and a flavoring agent, a surfactant and a preservative are further added for preparing the oral liquid. A modern pharmaceutical technology is applied for changing biochemical pills to the oral liquid formulation which is easy to accept by women, thereby overcoming the shortcoming of being inconvenient to take orally of the original formulation; and the biochemical oral liquid is fast in medicament release speed, high in bioavailability, small in irritation, accurate in divided dose, small in volume and convenient to take and carry. The quality standard of the biochemical oral liquid is comprehensively improved on the original basis, a scientific qualitative and quantitative control method is provided, and the product quality is ensured.

Description

technical field [0001] The invention relates to a manufacturing process of a Chinese patent medicine oral liquid, in particular to a biochemical oral liquid for gynecological blood circulation, blood stasis dispelling and pain relief and a preparation method thereof. Background technique [0002] Shenghua Wan is derived from the classic prescription in "Fu Qingzhu Gynecology" by Fu Shan, a famous doctor of gynecology in the Qing Dynasty. It is composed of 5 traditional Chinese medicines. Significant effect. Postpartum lochia does not work, and the cold pain in the lower abdomen is caused by congestion and internal resistance, and coldness, so the main treatment is to promote blood circulation and remove blood stasis. [0003] Shenghua pills have been included in the drug standards of the Ministry of Health of the People's Republic of China, but the original dosage form is single, and the process is simple and rough, which is far from meeting people's drug needs. Contents ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/00A61P15/00A61P29/00
Inventor 李安平董迷柱菅晓勇李建伟武勇聂磊
Owner SHANXI ZHENDONG PHARMA
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