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A series of traditional Chinese medicine preparations for treating colds in children and its preparation process and detection method

A technology for traditional Chinese medicine preparations and children's colds, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of affecting the curative effect, loss of volatile oil and active ingredients, etc., shortening the production cycle, reducing the process and turnover. , to ensure the effect of clinical efficacy

Active Publication Date: 2012-02-15
SHANDONG MINGREN FURUIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, Chinese patent 200510088659.8 discloses a patent for Xiaoer Jiegan effervescent tablet and its preparation method. It only reformed the dosage form, but the volatile oil also adopts the spraying technology, and the granulation also adopts the traditional granulation technology, so it still exists Insufficient effect on curative effect due to loss of volatile oil and active ingredients

Method used

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  • A series of traditional Chinese medicine preparations for treating colds in children and its preparation process and detection method
  • A series of traditional Chinese medicine preparations for treating colds in children and its preparation process and detection method
  • A series of traditional Chinese medicine preparations for treating colds in children and its preparation process and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Take 125 parts by weight of Campanulaceae and pulverize into fine powder; add 415 parts by weight of Bupleuri, add 6 times the amount of water, soak for 6 hours, distill and extract the volatile oil for 3 hours, collect the distilled volatile oil distillate and aqueous solution in another device; take the distillate of volatile oil, add β -Cyclodextrin (100ml:1g), stirred at 30°C for 4h, clathrate into clathrate; 830 parts by weight of medicinal residues and Folium baicalensis, 415 parts by weight of Scutellaria baicalensis, 415 parts by weight of Schizonepeta, 125 parts by weight of bellflower, 165 parts by weight of licorice Mix the parts by weight, add water to decoct twice, add 6 times the amount of water to decoct twice (3, 2 hours in sequence), combine the decoction and the distilled aqueous solution of Bupleurum radix, filter, and concentrate the filtrate until it is measured at 60-80°C. To obtain a concentrated solution with a relative density of 1.20-1.25, add e...

Embodiment 2

[0115] Take 125 parts by weight of Campanulaceae and pulverize into fine powder; add 415 parts by weight of Radix Bupleurum, add 6 times the amount of water, soak for 6 hours, distill and extract the volatile oil for 5 hours, collect the distilled volatile oil distillate and aqueous solution in another device; take the distillate of volatile oil, add β -Cyclodextrin (100ml: 6g), stirred at 60°C for 2h to form an inclusion compound; 830 parts by weight of medicinal residues and Folium baicalensis, 415 parts by weight of Scutellaria baicalensis, 415 parts by weight of Schizonepeta, 125 parts by weight of platycodon grandiflorum, 165 parts by weight of licorice Mix the parts by weight, add water to decoct twice, add 6 times the amount of water to decoct twice (3, 2 hours in sequence), combine the decoction and the distilled aqueous solution of Bupleurum radix, filter, and concentrate the filtrate until it is measured at 60-80°C. To obtain a concentrated solution with a relative de...

Embodiment 3

[0117] Take 125 parts by weight of Campanulaceae and pulverize into fine powder; add 415 parts by weight of Bupleurum, add 6 times the amount of water, soak for 6 hours, distill and extract the volatile oil for 5 hours, collect the distilled volatile oil and aqueous solution in another device; take the volatile oil, add β-cyclodextrin In aqueous solution (4%) (2g: 100ml), stirred at 30°C for 4h to form clathrates; 830 parts by weight of medicinal residues and Folium Folium, 415 parts by weight of Scutellaria baicalensis, 415 parts by weight of Schizonepeta, 125 parts by weight of Campanulaceae, Mix 165 parts by weight of licorice, add water to decoct twice, add 8 times the amount of water to decoct twice (3 and 2 hours in turn), combine the decoction and the distilled aqueous solution of Bupleurum radix, filter, and concentrate the filtrate to 60-80 The concentrated solution with a relative density of 1.20-1.25 was measured at ℃, added ethanol to make the alcohol content 70%, s...

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Abstract

The invention discloses a series of traditional Chinese medicine preparations for treating colds in children, as well as their preparation process and quality control method, which are characterized in that they are prepared from traditional Chinese medicines such as Folium Folium Folium, Bupleurum Radix, Scutellaria Baicalensis, Nepeta Nepeta, Platycodon grandiflorum, Licorice and medicinal auxiliary materials. It has the effects of clearing away heat, relieving exterior syndrome, reducing inflammation and relieving cough, and is used for cold and fever, headache and stuffy nose, cough and sneeze, and sore throat. Bupleurum volatile oil is the material basis for the “antipyretic” formula of this preparation. It has the characteristics of rapid antipyretic and is an effective ingredient for treating children with exogenous fever. The traditional preparation process is to use volatile oil spraying. It is almost lost in the process of production and storage, which seriously affects the clinical efficacy. The present invention adopts β-cyclodextrin inclusion technology to carry out the inclusion of Bupleurum volatile oil, so that the liquid drug is solidified, reduces the loss of volatile oil in the process of production and storage, improves the stability of the drug, and ensures the clinical curative effect of the drug . In addition, the present invention also has a more complete quality control method to ensure the quality, and also enriches the dosage forms for clinical use, which can better meet the needs of clinical medication.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation process and a quality control method of a series of traditional Chinese medicine preparations for treating infantile colds. 2. Background technology [0002] Infantile cold is one of modal childhood disease, shows according to the result of World Health Organization statistics, and cold occupies the first place in pediatric disease. Common symptoms of colds in children are fever, nasal congestion, runny nose, cough, etc., mainly fever, often high fever, and even convulsions; traditional Chinese medicine believes that children are in the process of growth and development, full of vitality and rapid development, but the viscera Delicate, lacking body energy, immature material bases such as essence, blood, body fluid and various physiological functions in the body; therefore, the resistance to diseases is poor, and children cannot adjust themse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/48A61K36/539A61P11/00G01N30/02G01N30/90
Inventor 凌沛学张玲吴维群贾美春张海立刘妍妍
Owner SHANDONG MINGREN FURUIDA PHARMA
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