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Amur valeriana extract and preparation method and applications thereof

A blackwater valerian extract technology, applied in the field of blackwater valerian active ingredient extract and its preparation, can solve the problems of valerianoid damage and other problems

Active Publication Date: 2011-07-06
都晓伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem that existing extraction methods destroy valerianoids very much, the object of the present invention is also to provide the extraction method of described blackwater valerian extract, which can retain the valerianins, Valerenic acids and volatile oils

Method used

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  • Amur valeriana extract and preparation method and applications thereof
  • Amur valeriana extract and preparation method and applications thereof
  • Amur valeriana extract and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 SFE-CO 2 Extraction method:

[0022] 1. Selection of the type of entrainer

[0023] Take black water valerian root powder, pass through a 20-40 mesh sieve, weigh a certain weight, according to the extraction conditions: extraction temperature 40°C, extraction pressure 30Mpa, analysis temperature 35°C, analysis pressure 5MPa, CO 2 The flow rate is 15L / h, the extraction time is 1.5h, and the amount of entrainer is 200ml. Use methanol, absolute ethanol or 95% ethanol as the entrainer for extraction. The extract is fixed to volume with ethanol, and dried under reduced pressure at 35°C until it has no alcohol smell. Weigh and calculate the ointment rate.

[0024] The extraction results of different entrainers are shown in Table 1.

[0025] Table 1

[0026]

[0027] Note: mg / g represents the amount of active ingredients extracted from 1g of black water valerian

[0028] As can be seen from the above, 95% ethanol has a relatively high extraction amount of val...

Embodiment 2

[0061] Embodiment 2 percolation method

[0062] Take black water valerian root powder, pass through a 20-40 mesh sieve, weigh 50g, infiltrate with 60ml 95% ethanol for 2 hours, then place it on the column for 24 hours, percolate with 95% ethanol, and collect the percolation liquid at a speed of 1ml / min , the content of valerenic acid and valerenin in the percolation liquid was determined in units of column volume, when the sixth column volume was collected, valerenic acid and valerenin were barely detected. Combine the percolates, dilute to volume with 95% ethanol, dry under reduced pressure at 35°C until there is no alcohol smell, weigh them, and calculate the paste rate.

[0063] Take 1 g of the obtained dry paste, weigh it accurately, add an appropriate amount of methanol, and ultrasonically treat it for 20 min, and then set the volume to a 25ml measuring bottle with methanol, and use HPLC to measure the contents of valerenic acid and valerenin in the dry paste respectively...

Embodiment 3

[0067] Embodiment 3 extraction method

[0068] Take black water valerian root powder, pass through a 20-40 mesh sieve, weigh 20g, add 400ml of 95% ethanol to soak overnight, then stir with an electric stirrer for 4 hours, filter, collect the filtrate, and dilute to volume with 95% ethanol at 35 Dry under reduced pressure at ℃ until there is no alcohol smell, weigh and calculate the paste rate.

[0069] Take 1 g of the obtained dry paste, weigh it accurately, add an appropriate amount of methanol, and ultrasonically treat it for 20 min, and then set the volume to a 25ml measuring bottle with methanol, and use HPLC to measure the contents of valerenic acid and valerenin in the dry paste respectively. The remaining dry paste was extracted with steam distillation to extract the volatile oil, and the content of volatile oil in the dry paste was calculated. The results are shown in Table 7.

[0070] Table 7 Extraction test results by extraction method

[0071]

[0072] Note: mg...

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Abstract

The invention relates to an extract of Amur valeriana active components, particularly relates to an extract obtained by carbon dioxide supercritical extraction and the preparation method of soft capsules thereof, as well as applications thereof in the filed of pharmaceuticals and health food. The Amur valeriana extract is obtained by carbon dioxide supercritical extraction and contains volatile oil, valtrale, valerienic acid. Through pharmacological tests, it is proven that the extract has the effects of tranquillizing mind, promoting sleeping and resisting depression. The preparation methodcomprises the following steps: preparing capsule shell from gelatin, glycerol, water and other raw materials and clathrating to obtain soft capsules.

Description

technical field [0001] The present invention relates to black water valerian extract, especially relates to black water valerian active ingredient extract and preparation method thereof, also relates to its soft capsule preparation and application. Background technique [0002] Valerian is one of the oldest herbal medicines in Europe. It has been used as a sedative since the middle of the eighteenth century. The valerian preparation developed for therapeutic effect plays a pivotal role in the European and American botanical medicine market, and has been imported to China at a relatively high price in recent years, but there is no domestic valerian preparation on the market. [0003] Blackwater valerian and European valerian are related plants of the same genus. Blackwater valerian Valeriana amurensis Smir.ex Kom. is a medicinal plant of the genus Valeriana in the family Patillaceae. It has not been recorded in the herbal books of the past dynasties in my country, only the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P25/20A61P25/24
Inventor 都晓伟梁朝锋
Owner 都晓伟
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