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Preparation technology and production method of integrated Xiaojianzhong decoction novel dosage form

A technology of Xiaojianzhong decoction and production method, which is applied in non-central analgesics, anti-inflammatory agents, pharmaceutical formulas, etc., can solve the problems of less research on the preparation of active ingredients of compound Chinese medicines, and achieve the effect of wide target distribution

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research and development of new drugs at home and abroad mainly focus on the preparation of single drugs, and there are already patented products, but there are few studies on the preparation of active ingredients of compound Chinese medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0040] The composition of the raw materials used to make the active ingredients is——

[0041] 30 parts of caramel, 9 parts of cinnamon sticks, 18 parts of peony, 9 parts of ginger, 6 parts of jujube, and 6 parts of roasted licorice.

[0042] Its manufacturing process is as follows:

[0043] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the prod...

Embodiment 2

[0045] Prepare the following raw materials according to the aforementioned method: water decoction concentrate, nano liposome, nanoemulsion, microemulsion, nano suspension.

[0046] The composition of the raw materials used to make the active ingredients is——

[0047] 30 parts of caramel, 9 parts of cinnamon sticks, 18 parts of peony, 9 parts of ginger, 6 parts of jujube, and 6 parts of roasted licorice.

[0048] Its manufacturing process is as follows:

[0049]In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, ...

Embodiment 3

[0051] Prepare the following raw materials according to the aforementioned method: extract, solid lipid nanoparticles, and nanoemulsion.

[0052] The composition of the raw materials used to make the active ingredients is——

[0053] 30 parts of caramel, 9 parts of cinnamon sticks, 18 parts of peony, 9 parts of ginger, 6 parts of jujube, and 6 parts of roasted licorice.

[0054] Its manufacturing process is as follows:

[0055] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, t...

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Abstract

The invention relates to a preparation technology and production method of an integrated Xiaojianzhong decoction novel dosage form. The integrated novel dosage form comprises the following active ingredients in parts by weight: 30 parts of malt sugar, 9 parts of cassia twig, 18 parts of peony, 9 parts of ginger, 6 parts of Chinese dates and 6 parts of radix glycyrrhizae preparata. The production process comprises the following steps: extraction in aqueous alcohol, ultrasonic grinding and extraction, microwave extraction, decoction in water and concentration, spray drying, high-pressure homogenizing, nanoscale grinding, nanoparticle preparation and the like. In the method, the stress is laid on the advantages of multi-synergy and multi-target effects of nano traditional Chinese medicines. After scale industrial production, the production cost can be substantially lowered, the product quality can be improved and the targeting and slow / controlled release properties of the medicines are stronger. After the novel dosage form is prepared into films, the films can be stuck to the skins of the human bodies and are used for treating the diseases through percutaneous absorption.

Description

technical field [0001] The invention relates to the preparation technology of the new dosage form of the integrated Xiaojianzhong decoction, and also relates to the preparation technology of the new dosage form of the integrated Xiaojianzhong decoction and its production method. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. Traditional Chinese medicine compound prescription embodies the holistic view, system theory, and syndrome differentiation and treatment principles of traditional Chinese medicine treatment, which emphasizes strengthening the body and eliminating pathogenic factors, and treating both symptoms and root causes. What a single ingredient can sum up. The efficacy of the compound medicine is not only related to the active substances or groups of effective substances, but also related to the auxiliary components. When the traditional Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/00A61P1/04A61P1/16A61P25/20A61P7/06A61P29/00A61P35/02A61P35/00A61P31/06A61K31/7016
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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