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Traditional Chinese medicine composition for treating iron deficiency anemia and preparation method thereof

A technology for iron-deficiency anemia and a composition, applied in the field of pharmacy, can solve problems such as iron malabsorption, and achieve the effects of less dosage, significant curative effect, and simple preparation process

Active Publication Date: 2012-12-26
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Iron malabsorption: iron deficiency anemia due to iron absorption disorder is relatively rare

Method used

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  • Traditional Chinese medicine composition for treating iron deficiency anemia and preparation method thereof
  • Traditional Chinese medicine composition for treating iron deficiency anemia and preparation method thereof
  • Traditional Chinese medicine composition for treating iron deficiency anemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, granules of the present invention

[0042] Prescription: soap alum 4.5g, astragalus 270g, hawthorn 270g, new donkey-hide gelatin 90g, jujube 90g

[0043] Preparation method: decoct astragalus, hawthorn, and jujube with water twice, 2 hours each time, add water 10 times and 8 times respectively, combine the decoctions, concentrate to a clear paste with a relative density of 1.08 (measured at 80°C), add Equal amount (calculated by volume) of 95% ethanol, let it stand for 48 hours or centrifuge, concentrate the supernatant or centrifugate to a clear paste with a relative density of 1.29-1.31 (measured at 80°C), and filter. Crush soap alum and new donkey-hide gelatin, mix the fine powder with the above-mentioned clear paste, sugar powder, and dextrin, and make granules to obtain. (1000g granules)

Embodiment 2

[0044] Embodiment 2, drug effect test of the present invention

[0045] 1 Materials and methods

[0046] 1.1 Sample

[0047] Granules of the present invention: Example 1 of the present invention, the specification is 10g / bag; ferrous sulfate sheet, containing ferrous sulfate is 0.3g / sheet, provided by Jinan Yongning Pharmaceutical Co., Ltd., batch number 20051211.

[0048] 1.2 Experimental animals

[0049] A total of 70 SPF-grade female weaned Wistar rats, weighing 50-60 g, were selected from the Experimental Animal Center of Shandong Medical University. The breeding environment is a barrier-level animal room, and the license number for the use of experimental animals is: SYXK-(Lu) 2006-0025. Low-iron feed was provided by the Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention.

[0050] 1.3 Dose selection

[0051] The granules of the present invention are provided with low and high dosage groups, which are respectively 0.5 and 1.0 g / k...

Embodiment 3

[0085] Embodiment 3, clinical observation result report is as follows:

[0086] clinical information

[0087] A total of 224 cases of iron deficiency anemia were treated. Among them, there were 32 males and 192 females; the age ranged from 10 months to 79 years, with an average age of 36 years; the time since the onset of symptoms came to the hospital for 1 month to 22 years, and the average disease duration was 5.6 years.

[0088] 224 cases were divided into three groups for observation: 101 cases in the granule group of the present invention, 93 cases in the Jianpi Shengxue Tablet group, and 30 cases in the ferrous sulfate group. Before each case takes the medicine, fill in the observation form of pre-selected design. The content of the form mainly includes the detection values ​​of hemoglobin, red blood cell count and other clinical symptoms related to anemia.

[0089] Treatments and Outcomes

[0090] 1. Treatment

[0091] 1. Drug composition: Granules of the present in...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating iron deficiency anemia and a preparation method thereof, belonging to the field of pharmacy. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials of melanterite, radix astragali, haw, new donkey-hide gelatin and Chinese date.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating iron deficiency anemia and a preparation method thereof. Background technique [0002] Iron deficiency anemia (iron deficiency anemia, IDA) is a common anemia caused by the lack of iron in the body and affects the synthesis of hemoglobin. Both concentration and serum transferrin saturation were decreased. Typical cases of anemia are small cell hypochromic type. [0003] Iron-deficiency anemia is a common type of anemia that is prevalent all over the world. The incidence rate of this anemia is very high in women of childbearing age (especially pregnant women) and infants and young children. The clinical epidemiological survey of high-risk groups in Shanghai area shows that the prevalence rate of iron deficiency anemia in menstrual women, preg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61P7/06A61K33/26A61K35/36
Inventor 周万辉王冬梅赵磊
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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