Matrix carrier compositions, methods and uses

Abstract

Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.

Description

Matrix carrier composition, method and use field of invention The present invention relates to matrix carrier compositions, methods for their preparation and their use, for example in drug delivery systems. Background of the invention Oral delivery is considered a convenient and widely accepted route of drug administration. Achieving good oral bioavailability of a drug is the cornerstone of effective oral therapy. The use of effective drug carriers with low bioavailability enables effective oral administration with increased drug potency and can be used for new drugs as well as for older drugs that have historically not been able to be orally administered. The term bioavailability in relation to oral administration of a drug refers to the percentage of the drug that has reached the systemic circulation after oral administration, taking into account the absorption and metabolism of the drug. Bioavailability can be influenced / dependent on several factors, some of which ar...

AI Technical Summary

Problems solved by technology

Thus, the most common route of protein drug administration is the parenteral route, which has several disadvantages such as, for example, being inconvenient for the patient and more expensive in terms of drug administration

There is therefore an unmet medical need for effective non-parenteral administration of protein drugs that provide prevention of biodegradation, improved pharmacokinetics, and reduced toxicity

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