Method for synthesizing aromatic amine

Abstract

The invention provides a method for synthesizing aromatic amine. A reaction formula is shown in the specifications, wherein when X is nitrogen, a substituent group R can be 3- / 5-nitro, 3- / 5-cyan, 3- / 5-trifluoromethyl or 3- / 5-halo (fluorine, chlorine, bromine or iodine); when X is carbon, R can be 2- / 4-nitro, 2- / 4-cyan, 2- / 4-trifluoromethyl or 2-nitro-4-chlorine; R1 and R2 refer to hydrogen, alkyl, alkyl alcohol, benzyl or-(CH2)n-(n=2-6) naphthenic base respectively; reaction alkali is caesium carbonate, potassium phosphate, pyridine, triethylamine, sodium bicarbonate, potassium carbonate, sodium / potassium hydroxide or sodium / potassium alkoxide; a reaction solvent is dioxane, toluol, dimethyl sulfoxide, dimethyl formamide, acetonitrile, tetrahydrofuran or acetone; and the reaction is implemented in the conventional heating state. In the method, raw materials are readily available, the process is simple, the reaction condition is mild, the application range is wide, and a plurality of aromatic amine compounds can be synthesized by different substrates.

Description

A kind of method of synthesizing aromatic amine (1) Technical field The invention relates to a synthesis method for preparing aromatic amine (arylamine in English) through the reaction of aromatic trifluoromethanesulfonate and zinc chloride complex of secondary amine. (2) Background technology Aromatic amine compounds are extremely important organic raw materials, widely used in the production of dyes, medicines, agricultural chemicals, additives, surfactants, textile auxiliaries, chelating agents, polymers, flame retardants, etc. (Catal.Commun., 2007, 8, 629). For example, p-nitrodimethylaniline (p-NDMA) can be used for the determination of sliding arc discharge degradation methyl violet (Journal of Zhejiang University <Engineering Science Edition>, 2009, 43, 931); RT base (N-phenyl-1 , 4-phenylenediamine) is an important intermediate for the production of various rubber antioxidants with excellent properties (Journal of Nanjing Institute of Chemical Technology, 19...

AI Technical Summary

Problems solved by technology

In summary, in the known synthetic methods of aromatic amines, either the temperature is higher, or the reaction time is longer, or the required reagents are expensive, difficult to preserve, poor in stability, and cumbersome to use and operate.

These deficiencies have brought a lot of inconvenience to the synthesis of this type of compound, especially industrialized production

Images