Method for preparing spherical carbon aerogel with specific absorbability for low density lipoprotein

Abstract

The invention relates to a method for preparing spherical carbon aerogel with specific absorbability for low density lipoprotein, which comprises: mixing a phenol and an aldehyde according to a ratio to form a precursor, preparing nano silica sol as a template agent, performing a sol-gel reaction in a dispersed phase containing surfactant, performing supercritical drying, carbonizing and etching steps to obtain pure carbon aerogel spheres; and coating the carbon aerogel spheres with a polymer material with high biological compatibility and rich free radicals on surface, coupling the carbon aerogel spheres with anion groups by using a coupling agent, and drying to obtain the spherical carbon aerogel with specific absorbability for low density lipoprotein. Compared with the prior art, the spherical carbon aerogel has large internal and external specific surface area and a large amount of negative charges on surface, and therefore can absorb a large amount of low density lipoprotein (LDL) with positive charges on surface; meanwhile, the spherical carbon aerogel does not have obvious absorption effect on beneficial ingredients in blood such as high-density lipoprotein, a carrier and a genin both have high biological compatibility, and an absorbent can be used as a hemoperfusion absorbant for treating hyperlipemia.

Description

Preparation method of spherical carbon airgel with specific adsorption on low-density lipoprotein technical field The invention relates to the field of carbon materials, in particular to a method for preparing spherical carbon aerogels capable of specifically adsorbing low-density lipoproteins. Background technique Cardiovascular and cerebrovascular diseases caused by atherosclerosis have become the main diseases that threaten human health and life. Medical research shows that elevated low-density lipoprotein (LDL) concentration in the blood is the main pathogenic factor of atherosclerosis, and many techniques and drugs have been developed to reduce the level of LDL in the blood. Among them, the use of hemoperfusion and adsorbents to selectively remove LDL in the blood to treat hyperlipoproteinemia is a very safe, fast and effective therapy, especially for familial hyperlipidemia that is ineffective for some drug treatment and diet control appear more meaningful. The key...

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Problems solved by technology

This kind of adsorbent has adsorption specificity and does not adsorb other substances, but the preparation cost is high and the price is expensive