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Production method of silymarin

A production method, the technology of silymarin, applied in the direction of organic chemistry, etc., can solve the problems of harmful solvent residue, low production efficiency, high production cost, etc., and achieve the effects of avoiding use and residue, improving work efficiency and reducing production cost

Active Publication Date: 2013-09-11
内蒙古昶辉生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The embodiment of the present invention provides a production method of silymarin, which is used to solve the defects of harmful solvent residue, high production cost, cumbersome process and low production efficiency in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 80 tons of milk thistle seeds are dehulled by a sheller to obtain 38 tons of milk thistle shells, softened by steam for 1 hour, the temperature is about 110 ° C, and the output moisture is 8%. Extraction with horizontal extractor YJP300, the charging amount is 60% of the material compartment, the amount of 95% ethanol is 1:1, the temperature is 55-60°C, the extractor temperature is 50°C, the speed is 1r / 120min, continuous spraying, extraction for 5h. The leachate is concentrated to 20m 3 , add 30 ℃ 0.5% sodium bicarbonate aqueous solution 80m 3 , stirred rapidly for 1 hour, settled for 1 hour, washed with water until neutral after centrifugation, dried at 70°C for 10 hours, crushed and sieved. 2.8 tons of silymarin were obtained, the content of silybin and iso-silybin was 32.45% in total, and the total flavonoid content was 74.5%.

Embodiment 2

[0032] Example 2: 100 tons of milk thistle seeds were dehulled by a sheller to obtain 49.2 tons of milk thistle shells, which were softened by steam for 0.5 hours at a temperature of about 105° C. and a discharge moisture of 9.5%. Extraction with horizontal extractor YJP300, the charging amount is 70% of the material compartment, the amount of 85% ethanol is 1:1.5, the temperature is 55-60°C, the extractor temperature is 50°C, the speed is 1r / 80min, continuous spraying, extraction for 9h. The leachate is concentrated to 50m 3 , add 50 ℃ 0.3% potassium hydroxide aqueous solution 300m 3 , stirred rapidly for 0.5h, settled for 0.5h, centrifuged, washed to neutrality, dried at 70°C for 10h, crushed and sieved. 3.7 tons of silybin were obtained, the content of silybin and iso-silybin was 34.2%, and the total flavonoid content was 75.6%.

Embodiment 3

[0033] Example 3: 80 tons of milk thistle seeds were dehulled by a sheller to obtain 39.8 tons of milk thistle shells, which were softened by steam for 1 hour at a temperature of about 105° C. and a discharge moisture of 7.2%. Extraction with horizontal extractor YJP300, the charging amount is 65% of the material compartment, the amount of 75% ethanol is 1:0.8, the temperature is 55-60°C, the extractor temperature is 60°C, the speed is 1r / 120min, continuous spraying, extraction for 12h. The leachate was concentrated to 48.7m 3 , add 20 ℃ 0.8% potassium bicarbonate aqueous solution 480m 3 , stirred rapidly for 0.5h, settled for 10min, centrifuged, washed with water until neutral, dried at 70°C for 10h, crushed and sieved. 2.7 tons of silybin were obtained, the content of silybin and iso-silybin was 35.4%, and the total flavonoid content was 77.8%.

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Abstract

The invention provides a production method of silymarin, which comprises the following steps: shelling silybum marianum seeds; filling the silybum marianum shells into a softening tank, and softening the silybum marianum shells with vapor; filling the softened silybum marianum shells into a flat-turn extractor, and adding ethanol to carry out extraction, thereby obtaining an extracting solution; concentrating the extracting solution to a certain degree to obtain a concentrated solution; adding aqueous alkali into the concentrated solution, stirring and standing to precipitate; and filtering the precipitate, drying, pulverizing and screening. In the extraction process, no toxic or harmful reagent is adopted, and no solvent residue which is harmful to the product can be produced; the ultraviolet detection indicates that the total flavone content in the product can be higher than 70%, the contents of silybin and isosilybin can be higher than 30%, and the product yield is 3-4% of the silybum marianum seeds; and therefore, the invention has the advantages of high extraction efficiency, simple technique and low solvent consumption.

Description

technical field [0001] The embodiment of the present invention relates to a production method, in particular to a production method of silymarin. Background technique [0002] Silymarin is a mixture of flavonoid lignans derived from the seeds of the plant Silybum marianum in the family Asteraceae. Its main components include flavonoids such as silibinin, isosilibinin, dehydrosilibinin, silybinin and silybinin. Silymarin has the function of protecting the liver and promoting choleresis, and is mainly used for the treatment of liver diseases. Secondly, it also has obvious anti-lipid peroxidation, anti-radiation, scavenging free radicals, anti-gastric ulcer and other effects. It has good effects in reducing blood fat, preventing and treating atherosclerosis, preventing cerebral ischemia, and anti-platelet aggregation. Non-toxic, non-teratogenic and mutagenic. [0003] In the course of realizing the present invention, the inventor finds that there are at least the following ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D407/04
Inventor 廖小雪刘宏苏晓会赵永强
Owner 内蒙古昶辉生物科技股份有限公司
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