Nested nanostructured electrostatic spinning fiber membrane and preparation method thereof

Abstract

The invention discloses a nested nanostructured electrostatic spinning fiber membrane and a preparation method thereof. The nested nanostructured electrostatic spinning fiber membrane comprises nanofibers and nanoparticles, wherein the nanoparticles are encapsulated in the nanofibers, and the nanofibers and the nanoparticles are all biodegradable materials. The method for preparing the nested nanostructured electrostatic spinning fiber membrane comprises the following steps: uniformly mixing a polymer solution prepared from the nanoparticles and the nanofiber materials; and then carrying out electrostatic spinning on the obtained mixture so as to obtain the nested nanostructured electrostatic spinning fiber membrane the nanoparticles of which are encapsulated in the nanofibers. The structure of the nested nanostructured electrostatic spinning fiber membrane disclosed by the invention is novel and practical; because the electrostatic spinning fiber membrane is in a bilayer nanostructure, the problem of initial burst release existing in the process of loading medicaments in the nanoparticles is effectively solved; and the nested nanostructured electrostatic spinning fiber membrane is simple in preparation method, and has a broad application prospect in nano-medicines, nano-pharmacology and other release fields such as agriculture.

Description

Technical field [0001] The invention relates to a nano composite material and a preparation method thereof, and more specifically, to a nested nano structure composite film and a preparation method thereof. Background technique [0002] The development of nanotechnology has provided new concepts for optimal treatment and diagnosis in medicine. Biodegradable nanoparticles have broad application prospects in improving the controlled and targeted release of drugs. Because nanoparticles can enhance the mixing degree of drugs to improve the stability of drugs in the degradation process; they can also achieve targeted release at target locations and reduce side effects. Therefore, nanoparticles have been widely used as drug delivery systems. the study. Among all colloidal systems, nanoparticles are the most promising to meet the precise control requirements in these release systems. Due to the requirements of biomedicine for the biocompatibility and biodegradability of materials, al...

AI Technical Summary

Problems solved by technology

However, the instability of physical and chemical properties in aqueous solution limits the application of biodegradable nanoparticles as drug carriers

[0003] In addition, another problem in the development of nanoparticle drug sustained release system is burst release, that is, it will be released within a few minutes when encountering a medium. Therefore, how to achieve controlled release in a relatively long period of time is a problem worth exploring. topic