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Antibacterial and antiviral effective part extract of medicated leaven and medicinal use thereof

A technology of effective parts and Liushenqu, applied in the field of extracts from effective parts of traditional Chinese medicine, to achieve the effect of strong anti-influenza virus A and safe clinical drug use

Active Publication Date: 2011-05-25
匡海学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report of the antibacterial or antiviral effective part extract of Liushenqu. The present invention provides an extract of the antibacterial or antiviral effective part of Liushenqu, which can be used for the clinical treatment of gastrointestinal flu, gastrointestinal flora disorder and viral infection. It is also of great significance to improve the scientific and technological content of traditional Chinese medicine and realize the modernization of traditional Chinese medicine

Method used

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  • Antibacterial and antiviral effective part extract of medicated leaven and medicinal use thereof
  • Antibacterial and antiviral effective part extract of medicated leaven and medicinal use thereof
  • Antibacterial and antiviral effective part extract of medicated leaven and medicinal use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Take commercially available 6kg bran-fried Liushenqu dry coarse powder, add 95% ethanol 4 times the volume of Liushenqu, reflux and extract 4 times, 2 hours each time, filter, combine the filtrate; recover the ethanol under reduced pressure to a thick paste; The paste is diluted with water of 20 times the volume of the thick paste, and then extracted with petroleum ether, ethyl acetate, and n-butanol in sequence. The amount of each extract is 1 times the volume of the diluted thick paste, and the number of extractions should be as long as the extraction The liquid is clarified; the solvent is recovered under reduced pressure to obtain the components; the dry paste is obtained by freeze-drying. The ethyl acetate extracts 36 g of the paste with a rate of 0.6%; the n-butanol extracts 48 g of the paste with a rate of 0.8 %.

Embodiment 2

[0052] Take 6kg of bran-fried Liushenqu dry coarse powder, add 8 times the volume of Liushenqu with 80% ethanol, reflux and extract 4 times, 4 hours each time, filter, combine the filtrate; recover the alcohol under reduced pressure to a thick paste; use the thick paste 10 times the volume of the thick paste is diluted with water, and then extracted with petroleum ether, ethyl acetate, and n-butanol in turn. The amount of each extract is 3 times the volume of the diluted thick paste, and the number of extractions should be until the extract is clear Recover the solvent under reduced pressure to obtain the components; freeze-dry to obtain a dry paste, 48 g of the ethyl acetate extract fraction, and the extraction rate of 0.8%; the n-butanol extraction fraction, the extraction rate of 60 g, and the paste rate of 1.0%.

Embodiment 3

[0054] Take 200g of dry coarse powder of Jiao Liu Shenqu, add 5 times the volume of Liu Shenqu 95% methanol, reflux and extract 3 times, 3 hours each time, filter, combine the filtrate; recover the alcohol under reduced pressure to a thick paste; use 15 The thick paste is diluted with water of double the volume of the paste, and then extracted with petroleum ether, ethyl acetate, and n-butanol in sequence. The amount of each extract is 2 times the volume of the diluted paste, and the number of extractions should be until the extract is clear Recover the solvent under reduced pressure to obtain each component; freeze-dry to obtain a dry paste, 1.3 g of ethyl acetate extract, and a paste yield of 0.65%; n-butanol extract, 1.8 g of paste, and a paste yield of 0.9 %.

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Abstract

The invention discloses an antibacterial and antiviral effective part extract of medicated leaven and medicinal use of the extract as an antibacterial agent or an antiviral agent. The extract is prepared by the following steps of: (1) refluxing and extracting coarse powder of the medicated leaven by using low molecular alcohol to obtain an alcohol extract; and (2) extracting the alcohol extract by using ethyl acetate and n-butyl alcohol, and decompressing the extraction liquid to recover a solvent so as to obtain the extract. The antibacterial and antiviral effective part extract of the medicated leaven mainly comprises fermentation products fermented by the medicated leaven; and the effective part extract has higher antibacterial and antiviral activities, particularly has prominent effect on the common enteropathogenic bacteria and influenza virus, and has safe medication and no toxic or side effect.

Description

Technical field [0001] The present invention relates to an extract of effective parts of traditional Chinese medicine, in particular to an extract of fermented traditional Chinese medicine Liu Shenqu and a preparation method thereof. The present invention also relates to the use of the active extract in the preparation of antibacterial and antiviral drugs, and belongs to the effective part of traditional Chinese medicine. Extract field. Background technique [0002] Liu Shenqu is a Chinese medicinal material made from flour (and / or wheat bran), almonds, red bean, and fresh artemisia annua, fresh and spicy Polygonum, fresh cocklebur juice (or dry decoction) in a certain proportion through common fermentation. , Is the most widely used kind of traditional fermentation koji. Liushenqu is sweet, pungent, warm in nature, returns to the spleen and stomach meridian, has the function of invigorating the spleen and appetizing, dispelling cold, and has a divergent function. It is used for...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/899A61P31/04A61P31/12
Inventor 王秋红杨炳友夏永刚姜海付新王长福匡海学
Owner 匡海学
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