Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Levamlodipine and telmisartan compound preparation

A technology of levamlodipine and levamlodipine, applied in pill delivery, cardiovascular system diseases, drug combination, etc., can solve problems such as increased side effects, improve tolerance, good compliance, and improve quality of life Effect

Inactive Publication Date: 2011-05-18
SHIHUIDA PHARMA GRP (JILIN) LTD
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of antihypertensive treatment for hypertensive patients is to reduce the patient's blood pressure to the normal range or acceptable level as much as possible, reduce the risk of target organ damage caused by hypertension, and at the same time avoid the damage caused by antihypertensive drugs to the greatest extent. Side effects, and some studies have found that the antihypertensive effect of most antihypertensive drugs is not enhanced with the increase of dose, but its side effects are increased with the increase of dose

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Levamlodipine and telmisartan compound preparation
  • Levamlodipine and telmisartan compound preparation
  • Levamlodipine and telmisartan compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Telmisartan 80mg / levamlodipine 5mg bilayer tablet

[0035]

[0036]

Embodiment 2

[0037] Embodiment 2 Telmisartan 20mg / levamlodipine 2.5mg bilayer tablet

[0038]

Embodiment 3

[0039] Embodiment 3 Telmisartan 40mg / levamlodipine 2.5mg bilayer tablet

[0040]

[0041] Remarks: *Volatile components will not remain in the final product

[0042] Preparation process: granulate the telmisartan layer and levamlodipine layer according to the prescription amount, and then compress into tablets with a double-layer tablet press to obtain the product.

[0043] Dosage: Take orally, once a day, 1-2 tablets each time.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a levamlodipine and telmisartan compound preparation and an optimal compound formulation. In the invention, the combination of the levamlodipine and the telmisartan is used for treating hypertension, good synergic antihypertension effect is obtained between the levamlodipine and the telmisartan, the doses of the levamlodipine and the telmisartan can be reduced while the equivalent and even better antihypertension effect is achieved, and the adverse effect caused by high dose of single drug is reduced. Besides, the telmisartan can obviously improve the tolerance of the levamlodipine, can inhibit heart rate increase caused by the levamlodipine and can reduce the incidence of peripheral edema.

Description

technical field [0001] The present invention relates to a drug for treating hypertension, in particular to a compound preparation comprising levamlodipine or a pharmaceutically acceptable salt thereof and telmisartan and its optimal compound dosage form and application. Background technique [0002] In recent years, with the continuous improvement of people's living standards in our country and the change of dietary structure, the increase of life pressure, and the increase of the elderly population, the incidence of hypertension has gradually increased, and it will cause heart, brain, kidney, etc. It is closely related to the disorder of sugar and lipid metabolism and diabetes, which obviously reduces the quality of life of the patient, and even endangers the life of the patient in severe cases. However, a large number of international authoritative clinical studies on hypertension have shown that increasing the pressure reduction, actively and durably reducing the blood pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4422A61K31/4184A61P9/12A61K9/24
Inventor 李环杨彦玲薛传校张喜田任寅
Owner SHIHUIDA PHARMA GRP (JILIN) LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com