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Mesoporous silicon oxide particle/degradable polymer nano composite fiber, preparation method and application thereof

A technology of nanocomposite fibers and mesoporous silica, which is applied in the direction of non-active components of polymer compounds, chemical post-treatment of synthetic polymer artificial filaments, fiber treatment, etc., can solve problems such as composite materials that are rarely reported, and achieve improved mechanical properties. Effects of strength and biodegradability, high activity loading, high activity controlled release

Inactive Publication Date: 2011-05-11
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there have been many research reports on the controllable preparation, surface modification and application of MSNs, but few reports on their composites with nanofibers.

Method used

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  • Mesoporous silicon oxide particle/degradable polymer nano composite fiber, preparation method and application thereof
  • Mesoporous silicon oxide particle/degradable polymer nano composite fiber, preparation method and application thereof
  • Mesoporous silicon oxide particle/degradable polymer nano composite fiber, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of Mesoporous Silica Nanoparticles MSN-1

[0049] Weigh 1.116g of cetyl dimethyl sodium bromide, add 880 mL of deionized water, raise the temperature to 50°C, and keep the temperature for 2 hours until the cetyl dimethyl sodium bromide is completely dissolved. Then 52.8mL of 27% concentrated ammonia water was added, and after 10min, 5.6mL of ethyl orthosilicate was slowly added dropwise. Stir at constant temperature for 2h to stop heating, the reaction is terminated, and stand for aging for 2h. Then, pour off the supernatant, centrifuge and wash with ultrapure water and absolute ethanol twice respectively. Finally, it was extracted and refluxed in methanol / hydrochloric acid system for 24 hours, and then washed twice with ethanol. Finally dried, ground and collected. The obtained mesoporous material (referred to as MSN-1) was measured by X-Ray diffraction analysis, transmission electron microscope, nitrogen isothermal adsorption-desorption, etc. ...

Embodiment 2

[0050] Example 2 Preparation of Mesoporous Silica Nanoparticles MSN-2

[0051] Weighing 12g (EO 20 PO 70 EO 20 ; Average molecular weight is 5800, Aldrich company) add in the 37% concentrated hydrochloric acid of 312mL deionized water and 60mL. After the surfactant was completely dissolved, 27.5 mL of ethyl orthosilicate was added. After stirring at room temperature for 24 hours, it was then poured into a special airtight tetrafluoroethylene container and hydrothermally crystallized at 100°C for 24 hours. The obtained suspension was centrifuged, washed twice with water and ethanol, calcined at 600°C for 6 hours, and then ground. The obtained mesoporous material (referred to as MSN-2) has a pore size of 9.8 nm. BET calculation results show that the specific surface area of ​​the material is 520m 2 / g.

Embodiment 3

[0052] Example 3 Preparation of Mesoporous Silica Nanoparticles MSN-3

[0053] Weigh 0.98g of hexadecyldimethyl sodium bromide, add it into 380mL of deionized water, raise the temperature to 30°C, and keep the temperature for 2 hours until the hexadecyldimethyl sodium bromide is completely dissolved. Then 52.8mL of 27% concentrated ammonia water was added, and after 10min, 5.6mL of ethyl orthosilicate was slowly added dropwise. Stir at constant temperature for 2h to stop heating, the reaction is terminated, and stand for aging for 2h. Then, pour off the supernatant, centrifuge and wash with ultrapure water and absolute ethanol twice respectively. Finally, it was extracted and refluxed in methanol / hydrochloric acid system for 24 hours, and then washed twice with ethanol. Finally dried, ground and collected. The obtained mesoporous material (referred to as MSN-3) has a pore size of 3.6 nm. The specific surface area of ​​the material calculated by BET is 200m 2 / g.

[0054]...

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Abstract

The invention discloses a mesoporous silicon oxide particle / degradable polymer nano composite fiber, a preparation method and application thereof. The method comprises the following steps of: uniformly dispersing mesoporous silicon oxide particles into a solution of degradable polymers; and then preparing nano composite fibers by adopting an electrostatic spinning process, wherein the mesoporous silicon oxide particles are uniformly distributed in the degradable polymer fibers. Compared with traditional polymer fibers, the nano composite fiber can be used for better controlling the release ofdrugs and has quicker biodegradability and higher mechanical strength, and meanwhile, the fiber has better cellular compatibility. The nano composite fiber can be used as a tissue engineering support, a drug release vector, a wound coating material or a functional membrane.

Description

technical field [0001] The invention relates to a mesoporous material / polymer nanocomposite fiber and its preparation method and application, in particular to a mesoporous silicon oxide particle / degradable polymer nanocomposite fiber and its preparation method and application. Background technique [0002] With a structure similar to that of extracellular matrix (ECM) in vivo, high specific surface area / volume ratio and length / diameter ratio, high porosity and pore connectivity, and good biocompatibility and biodegradability, nanofibers, In particular, nanofibers based on biodegradable polymer materials have been shown to significantly promote cell adhesion, spreading, and directional growth, and exhibit excellent biological activity (Jin HJ, Fridrikh SV, Rutledge GC and Kaplan DL. Biomacromolecules, 2002, 3:1233; Li M, Mondrinos MJ, Gandhi MR, KoFK, Weiss AS and Lelkes PI. Biomaterials, 2005, 26:5999). Therefore, it is widely used as tissue engineering scaffold, controlled...

Claims

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Application Information

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IPC IPC(8): D01F4/00D01F9/00D01F6/92D01F1/10D01F11/02D01F11/00D01F11/08D01D5/00A61L15/32A61L15/28A61L15/26A61L27/24A61L27/22A61L27/20A61L27/18A61K47/42A61K47/36A61K47/34
Inventor 刘昌胜周奂君袁媛甘琪凯思·迈克林
Owner EAST CHINA UNIV OF SCI & TECH
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