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Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof

A technology of oral ulcer and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine oral ulcer double-layer patch and its preparation, can solve problems such as low anticipation and allergen ulcer, and achieve the effect of alleviating pain, reducing discomfort and strong adhesion

Inactive Publication Date: 2011-05-11
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, certain allergens may also cause ulcers through a series of reactions
Because the cause has not been identified so far, the expectations for the prevention and treatment of this disease are still low

Method used

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  • Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof
  • Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof
  • Chinese medicinal double-layer patch for treating oral ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. 8 grams of mint, 15 grams of honeysuckle, 5 grams of licorice, 10 grams of Chinese gall, decocted 3 times in water, 2 hours each time, concentrated the water extract to a specific gravity of 1.2-1.4, and centrifuged at a high speed; 2. Centrifuged liquid or concentrated Dried to obtain the crude extract; 3. Macroporous resin, eluted with water, concentrated after decolorization of the eluent, precipitated with 95% ethanol, placed in the refrigerator, filtered, vacuum-dried the filter cake, crushed and sieved or spray-dried to obtain off-white Extract in fine powder form.

Embodiment 2

[0042] Reflux 12 grams of mint, 20 grams of honeysuckle, 10 grams of licorice, and 15 grams of Gallnut, reflux with 75% ethanol, extract 3 times, concentrate the filtrate into an extract, add water to make the extract into a suspension, and wash with water through macroporous resin D301 After decolorization, the eluate is concentrated, precipitated with 95% ethanol, placed in the refrigerator, filtered, and the filter cake is vacuum-dried, pulverized, sieved or spray-dried to obtain an off-white fine powder extract.

Embodiment 3

[0044] 10 grams of mint, 150 grams of honeysuckle, 8 grams of licorice, 15 grams of gallnut, 10 grams of mint, 150 grams of honeysuckle, 8 grams of licorice, 15 grams of gall, reflux with 95% ethanol, extract twice, concentrate the filtrate into an extract, add water Make the extract into a suspension, elute with macroporous resin D301, water, decolorize the eluent, concentrate, precipitate with 95% ethanol, place in the refrigerator, filter, vacuum dry the filter cake, crush and sieve or spray dry to obtain the White fine powder extract.

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Abstract

The invention relates to a Chinese medicinal double-layer patch for treating oral ulcer. The patch consists of a medicine-containing adhesion layer and a water-insoluble protective layer, wherein the medicine-containing adhesion layer comprises 0.1 to 15mg of Chinese medicinal extract, carbopol, borneol, low-substituted hydroxypropyl cellulose and sodium carboxymethyl cellulose; the water-insoluble protective layer consists of ethyl cellulose and edible pigment; and the Chinese medicinal extract consists of 8 to 12g of mint, 15 to 20g of honeysuckle flower, 5 to 10g of liquoric root and 10 to 15g of Chinese gall. The double-layer patch medicine can fully improve local ulcer tissues and repair and cure the ulcer soon to fulfill the aim of treatment; the Chinese patent medicine is nontoxic and harmless to human bodies, is not required to be decocted and is convenient to administrate; the patch treats both symptoms and root causes and has obvious clinical curative effects; and the effective rate reaches 96 percent.

Description

technical field [0001] The invention relates to a medicine for treating oral diseases, in particular to a traditional Chinese medicine oral ulcer double-layer patch and a preparation method thereof. technical background [0002] Recurrent oral ulcers, also known as recurrent oral ulcers, among many oral diseases, except for dental caries and periodontal disease, recurrent ulcers are the most troublesome. It often repeatedly invades the non-keratinized epithelium in the oral cavity, such as the lip mucosa, buccal mucosa, and tongue mucosa, causing trouble and inconvenience to patients in speaking, swallowing, and eating. As early as the end of the nineteenth century, the course of recurrent oral ulcers has been fully recorded in history. In the first 24 hours, the symptoms are not obvious, and some people may have prodromal symptoms of tingling or burning pain. Three days later, red macules or papules appeared on the affected area, and the epithelium was corroded to form an ...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K9/70A61K47/38A61P1/02A61K35/64
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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