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Ginkgo biloba extract oral liquid and preparation method thereof

A technology of flavonoid oral liquid and ginkgo flavonoids, which is applied in the field of oral liquid, can solve the problems of not being able to guarantee the complete dissolution of the ingredients, the inability to guarantee the chemical stability of the ingredients, and the reduced flexibility of medication, so as to maintain chemical stability, prevent deterioration and sourness, and prolong The effect of shelf life

Active Publication Date: 2013-01-30
陕西汉方生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In addition, the ginkgo flavone oral liquid currently on the market contains a variety of other medicinal ingredients in addition to ginkgo biloba extract. Although the synergistic effect of the drugs on certain diseases is more significant than that of a single preparation, the drug is flexible. In addition, various medicinal ingredients and excipients are added together during the preparation process. Although there are fewer operating steps, it cannot guarantee the orderly and complete dissolution of each ingredient and cannot guarantee the chemical stability of each ingredient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The weight of each raw material contained in 1000ml oral liquid is: 30g of ginkgo flavonoid extract, 1.0g of sodium benzoate, 0.5g of aspartame, 0.5g of acesulfame potassium, 0.2g of peach flavor, and the rest is purified water. Wherein the flavonoid content in the ginkgo flavonoid extract is 25.1%.

[0038] The preparation method of ginkgo flavone oral liquid comprises the following steps:

[0039] (1) Add purified water to the preparation tank, heat to 100°C, and boil for 10 minutes;

[0040] (2) Add 30 g of ginkgo flavonoids extract to the solution obtained in step (1), stir and reflux at 100° C. for 10 min to make it all dissolve;

[0041] (3) add sodium benzoate 1.0g in the solution of step (2) gained, heat and boil 40min to make it all dissolve;

[0042] (4) Add 0.5 g of aspartame and 0.5 g of acesulfame potassium to the solution obtained in step (3), heat and boil for 40 minutes to make them all dissolve;

[0043] (5) Cool the solution obtained in step (4) to ...

Embodiment 2

[0048] The weight of each raw material contained in 1000ml oral liquid is: 60g of ginkgo flavonoid extract, 1.5g of sodium benzoate, 0.8g of aspartame, 0.8g of acesulfame potassium, 0.45g of peach essence, and the rest is purified water.

[0049] The preparation method of ginkgo flavone oral liquid is the same as in Example 1.

[0050] The oral liquid has a clear appearance without precipitation, and has been tested for a shelf life of more than one and a half years without deterioration.

Embodiment 3

[0052] The weight of each raw material contained in 1000ml oral liquid is: 80g of ginkgo flavonoid extract, 1.5g of aspartame, 1.5g of acesulfame potassium, 0.6g of peach flavor, and the rest is purified water.

[0053] The preparation method of ginkgo flavone oral liquid is the same as in Example 1.

[0054] The oral liquid has a clear appearance without precipitation, and has been tested for a shelf life of more than one and a half years without deterioration.

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Abstract

The invention discloses a ginkgo biloba extract oral liquid and a preparation method thereof. The ginkgo biloba extract oral liquid takes a ginkgo biloba extract as a medicinal component, and further contains auxiliary materials of sodium benzoate, aspartame, acesulfame and juice peach essence. 1000ml of oral liquid comprises the raw materials by weight as follows: 30-80g of the ginkgo biloba extract, 0.5-1.5g of the aspartame, 0.5-1.5g of the acesulfame, 0.2-0.6g of the juice peach essence, and the balance of water. The preparation method of the oral liquid comprises a plurality of steps, wherein the auxiliary materials are orderly added in different steps so as to ensure each component to be completely dissolved with the kept chemical stability.

Description

technical field [0001] The invention relates to an oral liquid, in particular to an oral liquid containing ginkgo biloba flavonoids, an extract of ginkgo leaves. Background technique [0002] Ginkgo tree has magical vitality and is known as "living fossil" and "longevity king". my country is the main producing area of ​​ginkgo trees, accounting for about 70% of the world's total. Ginkgo biloba is the leaf of Ginkgo biloba plant of Ginkgo family. According to analysis and determination, ginkgo leaves contain more than 160 kinds of ingredients, among which there are more than 30 kinds of flavonoid active substances with medicinal effects, and the content of flavonoids and terpene lactones in ginkgo leaves is relatively high. In addition, Ginkgo biloba also contains essential amino acids and beneficial trace elements. Different collection seasons have an impact on the content of flavonoids. In summer and autumn, the content of flavonoids in ginkgo leaves has little change, w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61K9/00A61P3/06A61P7/02A61P9/10A61P39/06A61K127/00
Inventor 江振鸣
Owner 陕西汉方生物制药有限公司
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