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Alpha-linolenic acid ester fat emulsion injection and preparation method thereof

A technology of intravenous injection and linolenic acid ester, which is applied in the field of medicine to achieve the effects of reducing blood viscosity, preventing asthma, and increasing oxygen carrying capacity

Inactive Publication Date: 2011-02-23
王京南
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that if DHA is deficient, vision will decrease and the recovery time of retinal reflexes will be prolonged

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Formula: 200g of refined ethyl α-linolenate, 12g of medicinal lecithin, 21g of medicinal glycerin, 0.5g of medicinal vitamin E, appropriate amount of dilute sodium hydroxide solution, and add water for injection to 1000ml.

[0059] 1. Preparation of oil phase liquid: take the prescribed amount of medicinal refined α-linolenic acid ethyl ester, medicinal lecithin and medicinal vitamin E, under the protection of nitrogen, heat to 80°C and stir to dissolve into oil phase liquid for later use;

[0060] 2. Prepare the aqueous phase liquid: take the medicinal glycerin and water for injection in the prescribed amount and stir evenly to form an aqueous phase liquid for later use;

[0061] 3. Colostrum emulsion: under the protection of nitrogen, under the high-speed stirring of the water phase liquid, slowly drop the oil phase liquid into the water phase liquid. After dripping, use a high-speed shear agitator to colostrumize for 15 minutes;

[0062] 4. Adjust the pH: under stirr...

Embodiment 2

[0068] Recipe: 200g of α-linolenic acid triglyceride, 13g of medicinal lecithin, 18g of medicinal glycerin, 5g of hydroxypropyl-β-cyclodextrin, appropriate amount of dilute sodium hydroxide solution, and add water for injection to 1000ml.

[0069] 1. Preparation of oil phase liquid: Take the medicinal refined α-linolenic acid triglyceride and medicinal lecithin in the prescribed amount, and under the protection of nitrogen, heat to 80°C and stir to dissolve into oil phase liquid for later use;

[0070] 2. Preparation of aqueous phase liquid: take the formula amount of hydroxypropyl-β-cyclodextrin, add it to water for injection and stir to dissolve, then add medicinal glycerin and stir evenly to form an aqueous phase liquid for later use;

[0071] 3. Primary emulsification: Under the protection of nitrogen, under the high-speed stirring of the aqueous phase liquid, slowly drop the oil phase liquid into the aqueous phase liquid. After the addition, use a high-speed shear agitator...

Embodiment 3

[0078] Formula: α-propylene glycol linolenate 200g, medicinal lecithin 8g, poloxamer 5g, medicinal glycerin 20g, hydroxypropyl-β-cyclodextrin 2g, hydroxypropyl methylcellulose 3g, acetic acid Appropriate amount of sodium dilute solution, add water for injection to 1000ml.

[0079] 1. Preparation of oil phase liquid: take the refined propylene glycol α-linolenate in the prescribed amount, add medicinal lecithin and poloxamer, and under nitrogen protection, heat to 80°C and stir to dissolve into oil phase liquid for later use;

[0080] 2. Preparation of aqueous phase liquid: take the formula amount of hydroxypropyl-β-cyclodextrin and hydroxypropyl methylcellulose, add water for injection and stir to dissolve, then add medicinal glycerin and stir evenly to form an aqueous phase liquid for later use;

[0081] 3. Primary emulsification: Under the protection of nitrogen, under the high-speed stirring of the aqueous phase liquid, slowly drop the oil phase liquid into the aqueous phas...

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PUM

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Abstract

The invention provides alpha-linolenic acid ester fat emulsion injection and a preparation method thereof. Alpha-linolenic acid esters, lecithin, glycerol, sterile purified water, an anti-oxidant, a stabilizing agent, a pH regulating agent and the like are taken as raw materials; and the preparation method comprises the following steps of: under the protection of nitrogen, mixing the raw materials, violently stirring, and shearing at a high speed to form primary emulsion; and emulsifying by using a high pressure homogenizing machine, filtering by using a microporous membrane filter, filling, sealing and sterilizing to obtain the alpha-linolenic acid ester fat emulsion injection. The alpha-linolenic acid esters are alpha-linolenic acid methyl ester, alpha-linolenic acid ethyl ester, alpha-linolenic acid ethylene ester, alpha-linolenic acid ethylene diester, alpha-linolenic acid propylene diester and alpha-linolenic acid triglyceride, and have the alpha-linolenic acid content of over 90 percent. The alpha-linolenic acid ester fat emulsion injection is applied in the fields of medical treatment and health, and can serve as nutritional and therapic medicine to be administrated through abenteric intravenous injection, intestinal tube feed or oral intake.

Description

[0001] technical field [0002] The invention belongs to the field of medicine, and relates to an α-linolenic acid ester fat emulsion intravenous injection and a manufacturing method thereof. Administered by gavage or orally. The α-linolenic acid ester fat emulsion intravenous injection is used for the prevention, treatment and nutritional supplementation of various diseases such as cardiovascular disease, diabetes, obesity, tumor, inflammation, allergy and depression. [0003] Background technique [0004] α-Linolenic acid, (Alpha–Linolenic acid, GLA) all-cis-9,12,15-octadecatrienoic acid (Alpha -9,12,15-Octadecatrienoic acid), belongs to the omega-3 class of polyunsaturated fatty acids (PUFA), there are three conjugated double bonds in the α-linolenic acid molecule, so it has very strong reducibility. [0005] α-linolenic acid is an essential nutrient that is necessary for human health but is generally lacking. It is an essential nutrient that needs to be supplemented ur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00A61P3/04A61P29/00A61P9/00A61P25/24A61K31/232A61P3/10A61P37/08A61P3/02A61K9/107
Inventor 王京南王孝荣
Owner 王京南
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