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In-situ gel composition for eyes

An in-situ gel and ophthalmic technology, which is applied in the direction of non-active ingredient medical preparations, active ingredient-containing medical preparations, peptide/protein components, etc., can solve the problem of ophthalmic in-situ gel without nerve growth factor And other issues

Active Publication Date: 2011-02-16
STAIDSON (BEIJING) BIOPHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But there is no ophthalmic in situ gel containing nerve growth factor

Method used

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  • In-situ gel composition for eyes
  • In-situ gel composition for eyes
  • In-situ gel composition for eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The proportioning ratio of this embodiment is shown in the following table:

[0063] NGF

[0064] Preparation method: Take an appropriate amount of water for injection, add gellan gum dispersedly while stirring, stir at 90°C to completely dissolve the gellan gum to form a transparent solution, and cool to room temperature. NGF, alanine, glycine, arginine, and benzyl alcohol are first dissolved in an appropriate amount of water for injection, and after sterilization and filtration, they are added to the gellan gum solution prepared above, and the water for injection is supplemented to a sufficient amount, stirred evenly, and sterile Subpackage.

Embodiment 2

[0066] The proportioning ratio of this embodiment is shown in the following table:

[0067] NGF

200μg / ml

Alanine

3.3mg / ml

Glycine

3.3mg / ml

arginine

3.3mg / ml

gellan gum

4mg / ml

Benzyl alcohol

9mg / ml

acetate buffer

Adjust to pH5.5

Mannitol

50mg / ml

Water for Injection

Appropriate amount

[0068] Preparation method: Take an appropriate amount of water for injection, add gellan gum and benzyl alcohol dispersedly while stirring, stir at 90°C to completely dissolve the gellan gum to form a transparent solution, and cool to room temperature. Dissolve NGF, alanine, glycine, arginine and mannitol in pH 5..5 acetate buffer solution, sterilize and filter, and freeze-dry by low-temperature freeze-drying method. Just before use, the gellan gum solution was added to the NGF freeze-dried solution, dissolved and mixed evenly.

[0069] The above-mentioned gellan gum is a microbial exopoly...

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Abstract

The invention relates to an in-situ gel composition for eyes, comprising the following materials: 50 mu g / ml-400 mu g / ml of nerve growth factor, 1 mg / ml-20 mg / ml of stabilizer, 3 mg / ml-10 mg / ml of ion sensitive gel and water; and the pH value of the in-situ gel composition is 4.5-7.5. In the invention, by using the composition and proportion and controlling the pH value of the in-situ gel composition to be within certain range, the in-situ gel preparation for the eyes containing nerve growth factors can be obtained. When being stored under the normal-temperature state, the preparation is liquid, and becomes a stable semisolid gel state after entering the eyes.

Description

technical field [0001] The invention relates to an ophthalmic in-situ gel composition. Background technique [0002] Excimer laser in situ keratomileusis (LASIK) is currently the mainstream procedure in corneal refractive surgery due to its advantages of mild postoperative reaction, high safety and good predictability. However, within 6 months after surgery, almost 50% of the cases experienced symptoms of dry eye, and some patients had discomfort such as foreign body sensation, which affected the satisfaction of patients with the surgery to varying degrees. Studies have found that the emergence of these symptoms and signs is related to the corneal nerves being damaged to varying degrees during the operation during the operation to cut the corneal flap and cut the corneal stroma. Drug research on promoting the repair of corneal nerve injury is a current research hotspot. [0003] Nerve Growth Factor (NGF) is the earliest neurotrophic factor discovered and the most thoroughl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P27/02A61K47/36A61K47/38A61K9/00A61K47/34A61K38/18A61K47/32A61K47/10
Inventor 谭剑平蒋立新潘铁成周志文
Owner STAIDSON (BEIJING) BIOPHARMACEUTICALS CO LTD
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