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Methods for preparing multiple environment-responding type hairy polymer micro-spheres and photo-initiation RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization thereof

An environment-responsive, polymer technology, which is applied in the field of preparation of multiple environment-responsive hair-like polymer microspheres and photo-initiated RAFT polymerization, can solve the unpublished preparation of environment-responsive hair-like polymer microspheres, and achieve The effects of expanding controllability, controllable structure, and wide application prospects

Inactive Publication Date: 2011-02-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the use of light-induced RAFT method to prepare environmentally responsive hair-like polymer microspheres has not been disclosed.

Method used

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  • Methods for preparing multiple environment-responding type hairy polymer micro-spheres and photo-initiation RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization thereof
  • Methods for preparing multiple environment-responding type hairy polymer micro-spheres and photo-initiation RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization thereof
  • Methods for preparing multiple environment-responding type hairy polymer micro-spheres and photo-initiation RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] step 1)

[0037] In a 1000ml reaction kettle equipped with a condenser tube, a thermometer and a mechanical stirrer, nitrogen was passed for 10 minutes in advance, and then 720gH 2 O, 180g styrene (St), 1.8g NaHCO 3 And 1.8gNaOH, nitrogen protection, treat that system temperature reaches 60 ℃, add 0.648g potassium persulfate (KPS) in the system as initiator (by mass ratio, H 2 O:St:NaHCO 3 : NaOH: KPS is 4: 1: 0.01: 0.01: 0.0036), after reacting for 8 hours, 1.8 g of hydroxyethyl methacrylate was added dropwise (by mass ratio, hydroxyethyl methacrylate: St was 0.01: 1), The dropwise addition time was 2 hours to obtain polystyrene (PS) microspheres with a particle diameter of 900 nm and hydroxyethyl methacrylate supported on the surface. Centrifuge the prepared microspheres in a high-speed refrigerated centrifuge for 15 minutes at a speed of 6000 rpm, then wash the obtained microspheres with deionized water, repeat the centrifugation and washing three times, and obtai...

Embodiment 2

[0043] step 1)

[0044] In a 1000ml reaction kettle equipped with a condenser tube, a thermometer and a mechanical stirrer, nitrogen was passed for 10 minutes in advance, and then 720gH 2 O, 7.2gSt, 3.6g divinylbenzene (DVB), 0.0144g KHCO 3 And 0.0144gKOH, nitrogen protection, treat that system temperature reaches 90 ℃, add 0.648gKPS in the system as initiator (according to mass ratio, H 2 O:St:DVB:NaHCO 3 : NaOH: KPS is 100: 1: 0.5: 0.002: 0.002: 0.09), after reacting for 1h, 0.72g hydroxypropyl methacrylate was added dropwise (by mass ratio, hydroxypropyl methacrylate: St was 0.1: 1 ), and the dropping time was 3h to obtain cross-linked PS microspheres with a particle size of 100nm and surface loading of hydroxypropyl methacrylate. Centrifuge the prepared microspheres in a high-speed refrigerated centrifuge for 15 minutes at a speed of 12,000 rpm, then wash the obtained microspheres with deionized water, and repeat the centrifugation and washing three times in this way to...

Embodiment 3

[0050] step 1)

[0051] In a 1000ml reaction kettle equipped with a condenser tube, a thermometer and a mechanical stirrer, nitrogen was passed for 10 minutes in advance, and then 720gH 2 O, 36gSt, 1.8g ethylene glycol dimethacrylate (EGDMA), 0.0144gNH 4 HCO 3 and 0.051 g of 28% NH 3 ·H 2 O, under nitrogen protection, when the temperature of the system reaches 80°C, add 0.72gKPS and 0.72g ammonium persulfate (APS) to the system as the initiator (by mass ratio, H 2 O:St:EGDMA:NH 4 HCO 3 : NH 3 ·H 2 O: KPS: APS is 20: 1: 0.05: 0.0004: 0.0004: 0.02: 0.02), after reacting for 5h, 10.8g of hydroxyisopropyl methacrylate was added dropwise (by mass ratio, hydroxyisopropyl methacrylate: St is 0.3:1), and the dropping time is 5 hours to obtain cross-linked PS microspheres with a particle size of 400 nm and surface-loaded hydroxyisopropyl methacrylate. Centrifuge the prepared microspheres in a high-speed refrigerated centrifuge for 15 minutes at a speed of 9500 rpm, then wash t...

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Abstract

The invention relates to methods for preparing a multiple environment-responding type hairy polymer micro-spheres and photo-initiation RAFT (Reversible Addition-Fragmentation chain Transfer) polymerization thereof. The hairy structure of the surface of the hairy polymer micro-spheres prepared by the invention is a polyN-isopropyl acrylamide, polyN-vinyl pyrrolidone, polyacrylic acid homopolymerization-type, diblock-type or triblock-type polymer brush. The hairy polymer micro-spheres have the advantages of controllable structure, temperature sensitivity and pH sensitivity, and can be used for protein renaturation, chemical valves, drug encapsulation and catalyzer loading and other aspects.

Description

technical field [0001] The invention relates to a method for preparing environment-responsive hair-like polymer microspheres by using the reversible addition-fragmentation chain transfer (RAFT) method, in particular to a method of loading RAFT reagents on the surface of the microspheres to prepare microspheres sensitive to temperature and pH. There are stimuli-responsive hair-like polymer microspheres. Background technique [0002] There are many methods for surface modification of materials, and hair-like microspheres are actually polymer chemical modifications to the surface of different microsphere substrates. The hair-like polymer microsphere refers to a special polymer structure formed by only one end of the molecular chain of the polymer brush being connected to the surface or interface of the polymer microsphere. Environmentally responsive hair mainly causes (reversible) changes in the surface properties of microspheres such as hydrophilic / hydrophobic, acidic / alkalin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08F257/02C08F2/38C08F265/04C08F2/48
Inventor 曹堃姚臻陈洁杜赞玲
Owner ZHEJIANG UNIV
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