Application of a kind of magnolia alkaloid
A technology of alkaloids and total alkaloids, which is applied in the extraction of alkaloids, the active ingredient of Magnolia officinalis, and the application field of α-glucosidase inhibitors, to achieve the effects of no environmental pollution, low cost, and simple extraction process
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[0018] 10kg of magnolia bark was crushed and extracted with 60L of 0.05% sulfuric acid water. The extract was passed through a D72 macroporous cation exchange resin column (column volume 6L), washed with 20L deionized water, and eluted with 30L of 1% ammonia / ethanol water (70% ethanol) solution. The eluate was evaporated to dryness to obtain 30 g of total alkaloids with a yield of 0.3%.
[0019] A total of 4.0 g of total alkali was taken, and five compounds were separated and purified by silica gel column chromatography (chloroform-methanol gradient elution), and they were identified as magnoliine, liriocarpine, and annonine by mass spectrometry, carbon nuclear magnetic resonance spectrum and hydrogen spectrum. , Roemerine and Lysicamine.
[0020] Take 50g of total alkali of Magnolia officinalis, add 3000g of starch and 30g of microcrystalline cellulose, granulate with 50% ethanol, and tablet to obtain tablets, 0.6g each, containing 10mg of total alkali, which is equivalent to 2g ...
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