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Traditional Chinese medicine compound preparation for treating respiratory disease and preparation method thereof

A compound preparation, respiratory technology, applied in respiratory diseases, antiviral agents, pharmaceutical formulations, etc., can solve the problems of large dosage, limited application, uncontrollable quality, etc.

Inactive Publication Date: 2011-01-05
GUANGZHOU LIXIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional dosage form of "Dayuan Decoction" is water decoction, its quality cannot be controlled, and its shelf life is low. It is inconvenient to take a large amount of medicine, especially for children, and the taste is poor, which limits its application and does not meet the market demand.
In order to give full play to the clinical efficacy of Dayuan Decoction, medical workers have done a lot of research on this classic formula, mainly focusing on its clinical pharmacological effects, but there is no such variety on the market at present.

Method used

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  • Traditional Chinese medicine compound preparation for treating respiratory disease and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating respiratory disease and preparation method thereof
  • Traditional Chinese medicine compound preparation for treating respiratory disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Take raw material medicine by following proportioning ratio:

[0143] Betel nut 6 parts Magnolia officinalis 3 parts Grass nut 1.5 parts Anemarrhena 3 parts

[0144] 3 parts of white peony, 3 parts of skullcap, 1.5 parts of licorice

[0145] (1) For the above Qiwei raw materials, take grass nuts, add 12 times the amount of water, extract the volatile oil by steam distillation, collect the volatile oil, and set aside;

[0146] (2) Get Magnolia officinalis and extract with 75% ethanol, extract the solution to recover the solvent under reduced pressure, concentrate, dry, pulverize to obtain the extract and set aside;

[0147] (3) Take the herb nuts and Magnolia officinalis, add 12 times the amount of water, heat and extract 3 times, 1 hour each time, combine the water extracts, filter, concentrate the filtrate to 1.05, add 95% ethanol to contain alcohol The volume is 75%, placed, filtered, and the solvent is recovered under reduced pressure, diluted with water to a certa...

Embodiment 2

[0150] Take raw material medicine by following proportioning ratio:

[0151] 5 parts of betel nut, 2.5 parts of Magnolia officinalis, 1.5 parts of grass nuts, 2.5 parts of Anemarrhena

[0152] 2.5 parts of white peony, 2.5 parts of skullcap, 1 part of licorice

[0153] Steps (1), (2) and (3) are the same as in Example 1, (4) the extracts in (2) and (3) are added with an appropriate amount of sucrose and dextrin, mixed evenly, made into granules, dried, and sprayed with ( 1) the volatile oil of the obtained grass nuts, and then prepare capsules according to a conventional process.

Embodiment 3

[0155] Take raw material medicine by following proportioning ratio:

[0156] Betel nut 6 parts Magnolia officinalis 3 parts Grass nut 1.5 parts Anemarrhena 3 parts

[0157] 3 parts of white peony, 3 parts of skullcap, 1.5 parts of licorice

[0158] (1) The above Qiwei raw materials are grass nuts, and supercritical carbon dioxide is used to extract volatile oil. The conditions are: extraction temperature is 50°C, pressure is 32Mpa, analysis temperature is 60°C, pressure is 6Mpa, and the average flow rate is 125kg / hour. After 0.5 to 4 hours, the volatile oil of grass nuts is obtained; after inclusion complexation with β-cyclodextrin, drying is obtained to obtain inclusion complexes;

[0159] (2) Get Magnolia officinalis and extract with 75% ethanol, extract the solution to recover the solvent under reduced pressure, concentrate, dry, pulverize to obtain the extract and set aside;

[0160] (3) Take the herb nuts and Magnolia officinalis, add 12 times the amount of water, heat ...

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for treating respiratory disease and a preparation method thereof. The traditional Chinese medicine compound preparation is prepared from raw material medicines, namely areca seed, officinal magnolia bark, amomum tsaoko, anemarrhena asphodeloides bunge, white paeony root, baical skullcap root and liquoric root. The traditional Chinese medicine compound preparation is prepared by the following steps of: distilling the amomum tsaoko by using steam or supercritically extracting the amomum tsaoko to collect volatile oil for later use; extracting the officinal magnolia bark by using ehanol, and concentrating extracting solution under reduced pressure and drying to obtain an extract; performing water boiling and alcohol precipitation on the rest medicines, adsorbing by using macroporous resin, collecting eluent, and concentrating and drying to obtain an extract; and mixing the dry extracts and the volatile oil to prepare the medicinal formulation. The extracts have obvious effects of clearing heat and releasing toxin and relieving cough and reducing sputum, and also have the effect of treating both principal and secondary aspect of the respiratory infectious disease through obvious anti-inflammatory, antibacterial and anti-virus action. The compound preparation has the characteristics of convenient carrying and administration, high bioavailability, and high controllability and stability.

Description

[0001] This application is a divisional application of an invention patent application with the application number 200610015522.4, the application date is August 31, 2006, and the invention title is "a Chinese medicine compound preparation for treating respiratory diseases and its preparation method". technical field [0002] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine compound preparation for treating respiratory diseases and a preparation method thereof. Background technique [0003] Common respiratory diseases mainly include influenza, common cold, acute tracheo-bronchitis, acute exacerbation of chronic bronchitis, bacterial pneumonia, viral pneumonia and atypical pneumonia, etc. Respiratory viruses often cause severe epidemic diseases, The danger of atypical pneumonia (SARS) has attracted great attention from all over the world; influenza is an acute respiratory disease caused by influenza virus, and...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61P11/00A61P31/16A61P31/12A61P31/04
Inventor 张铁军廖茂梁
Owner GUANGZHOU LIXIN PHARM CO LTD
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