Recombinant human interleukin-1 receptor antagonist in-situ gel
A receptor antagonist and in situ gel technology, applied in the field of medicine, can solve problems such as inaccurate extrusion dosage, inconvenient use, and inaccurate dosage
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Embodiment 1
[0024] Example 1. Recombinant human interleukin-1 receptor antagonist in situ gel No. 1
[0025] Take 15g of poloxamer 407, 15g of poloxamer 188, and 0.1g of gellan gum, add 50mL of boric acid buffer to fully swell into a uniform solution. Add 3mL IL-1ra receptor antagonist stock solution and 0.3g chlorobutanol. Mix evenly and divide for use. The in situ gel has dual functions of temperature sensitivity and ion sensitivity, and is a flowing liquid at room temperature ( figure 1 ), 5min at 37°C to form a gel ( figure 2 ). The in situ gel can be used in various administration routes and modes mentioned in the specification.
Embodiment 2
[0026] Example 2. Recombinant human interleukin-1 receptor antagonist in situ gel No. 2
[0027] Weigh 10 g of polyethylene glycol monomethyl ether / polylactic acid-glycolic acid copolymer (mPEG-PLGA) and 3 g of carbomer in 50 mL of water, stir and place it in a refrigerator at 4 °C with continuous shaking until mPEG- After PLGA swells, shake well to make a homogeneous solution. Add 3mL IL-1ra receptor antagonist stock solution, mix evenly, and dispense for use. The in-situ gel has dual effects of pH sensitivity and temperature sensitivity, and is a flowing liquid at room temperature, and becomes a gel within 5 minutes after intranasal administration. The in situ gel can be used in various administration routes and modes mentioned in the specification.
Embodiment 3
[0028] Example 3. Recombinant human interleukin-1 receptor antagonist in situ gel No. 3
[0029] Take 15g of poloxamer 407 and 15g of poloxamer 188, 0.1g of gellan gum, 2.5g of chitosan and add 50mL of water to fully swell to form a uniform solution. Add 3mL IL-1ra receptor antagonist stock solution, mix evenly, and dispense for use. The in-situ gel has dual functions of temperature sensitivity and ion sensitivity. At the same time, chitosan acts as an absorption accelerator. It is a flowing liquid at room temperature and forms a gel within 5 minutes after spraying into the nasal cavity. The in situ gel can be used in various administration routes and modes mentioned in the specification.
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