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Taste-masking tilmicosin gastric-soluble particle preparation

A technology for tilmicosin and granule preparations, which is applied in the field of stomach-soluble granule preparations, and can solve the problems of cumbersome clinical application and poor palatability of tilmicosin

Active Publication Date: 2010-11-10
烟台爱士津动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the injection is not taken orally, there is no problem of poor palatability, but due to the cumbersome clinical application, tilmicosin cannot actually exert its maximum effect when the disease breaks out on a large scale; other preparations such as solutions, powders, premixes, etc. They all belong to conventional oral preparations, and they fail to solve the problem of poor palatability of tilmicosin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Tilmicosin 10 parts

[0013] Low-substituted hydroxypropyl cellulose 80 parts

[0014] Sodium carboxymethyl cellulose 1 part

[0015] 9 parts of hydroxypropyl methylcellulose

Embodiment 2

[0017] Tilmicosin 40 parts

[0018] Microcrystalline cellulose 55 parts

[0019] PVP 0.5 copies

[0020] 4.5 parts of hydroxypropyl methylcellulose

Embodiment 3

[0022] Tilmicosin 70 parts

[0023] Polyethylene glycol 20 parts

[0024] Sodium carboxymethyl cellulose 0.2 parts

[0025] 8.8 parts of hydroxypropyl methylcellulose

[0026] Preparation method (the above three examples are prepared according to this method): mix tilmicosin and polymer carrier in proportion, pass through a 60-mesh sieve, add disintegrating agent to a suitable binder, granulate, and dry the obtained granules After passing through a 12-mesh sieve, the coating material is prepared into a 10% coating aqueous solution, and then the prepared gastric-soluble coating material is coated with a fluidized bed coating method, and the granules are dried and passed through a 10-mesh sieve for granulation Taste-masked tilmicosin gastric-soluble granules were obtained.

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PUM

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Abstract

The invention relates to a taste-masking tilmicosin gastric-soluble particle preparation, in particular to a gastric-soluble particle preparation consisting of a gastric-soluble coating material, a high-polymer carrier, a disintegrating agent and the like and aims to solve the problem of poor palatability of tilmicosin.

Description

technical field [0001] The invention relates to a taste-masking tilmicosin gastric-soluble granule preparation, mainly relates to a gastric-soluble granule preparation composed of a gastric-soluble coating material, a polymer carrier, a disintegrating agent, etc., so as to solve the problem of palatability of tilmicosin sex problem. Background technique [0002] Tilmicosin is a derivative of tylosin after acid hydrolysis. It is a semi-synthetic macrolide antibiotic for animals. Its molecular formula is C46H80N2O13 and its molecular weight is 869.15. Spain, the United States and other countries have been approved for clinical use. Tilmicosin has similar antibacterial activity to macrolides, and is effective against Gram-positive bacteria, some Gram-negative bacteria and mycoplasma. Especially for Actinobacillus pleuropneumoniae, Pasteurella, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Corynebacterium pyogenes and mycoplasma of livestock and poul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/706A61K47/38A61P31/04
Inventor 王永军吕淑荣梁玉李春杰
Owner 烟台爱士津动物保健品有限公司
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