Absorption film for eliminating bilirubin and preparation method thereof
An adsorption film and bilirubin technology, applied in the field of biomedical materials, can solve the problem that bilirubin molecules are difficult to be removed, and achieve the effects of improving biocompatibility, controllable deposition amount, and strong scalability
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0018] Using polyethyleneimine as the ligand of the adsorption film and the scavenging experiment on bilirubin, the steps are as follows:
[0019] The first step, the preparation of the adsorption membrane
[0020] A) Deposition of Chitosan
[0021] 1. 1% acetic acid solution containing chitosan 0.2g circulates outside the hollow fiber membrane (hemodialyzer outer chamber), controls ultrafiltration, and the ultrafiltration flow rate is 10ml / min, to remove a part of acetic acid in the chitosan solution or small molecules such as hydrochloric acid and water, and at the same time make chitosan fully adhere to the surface of the hollow fiber membrane.
[0022] 2. Change the pH of the inner and outer sides of the hollow fiber membrane to 12 to fully deposit chitosan.
[0023] B) Coupling ligand
[0024] The chitosan-deposited hollow fiber membrane was reacted with 1% glutaraldehyde solution at pH=8.0 at 40°C for 12h. After washing to remove free glutaraldehyde, react with 5% po...
Embodiment 2~16
[0029] Using different ligands to prepare adsorption membranes and scavenging experiments on bilirubin, the steps are the same as in Example 1, and the specific operating parameters and experimental results are shown in the following table:
[0030] implement
example
(%)
Acetic acid solution
liquid concentration
(m / v)
Ultrafiltration flow rate
(ml / min)
time
(min)
deposition
pH
Ligand
initial concentration
(mg / L)
Removal rate
2
0.5
0.5%
20
30
13
226.07
35.45%
3
0.5
0.5%
0.5
60
10
aminoethanol
253.15
16.14%
4
1.0
2.0%
5
50
13
2,3-Epoxypropyltri
233.52
26.27%
5 ...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com