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Application of 3-carbethoxy phenyl-beta-D-glucoside in treating chronic neuropathic pains

An ethoxycarbonyl phenyl, neurogenic pain technology, which is applied in the fields of medicine and sanitation and chemistry, and can solve problems such as being unsuitable for screening neuralgia treatment drugs and the like

Inactive Publication Date: 2012-05-23
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0037] Hot plate, tail flick, and writhing are classic animal models commonly used to screen acute pain analgesics, but they are not suitable for screening neuralgia drugs

Method used

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  • Application of 3-carbethoxy phenyl-beta-D-glucoside in treating chronic neuropathic pains
  • Application of 3-carbethoxy phenyl-beta-D-glucoside in treating chronic neuropathic pains
  • Application of 3-carbethoxy phenyl-beta-D-glucoside in treating chronic neuropathic pains

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0054] The specific pharmacological experiments are as follows:

[0055] 1. Test drug

[0056] Name: 3-ethoxycarbonylphenyl-β-D-acylated xyloside (XH016)

[0057]

[0058] Appearance: white crystal

[0059] Source: Synthesized by the Biochemical Pharmacology Group of the Natural Resources Medicinal Chemistry Laboratory of Yunnan University.

[0060] Drug preparation, administration volume, and administration route: before use, add 0.2% pure aqueous solution of carboxymethylcellulose sodium to grind and suspend to the desired concentration. Rats were intragastrically administered once a day, and the administration volume was 45mg / Kg, 10mL / Kg.

[0061] 2. Comparative drugs

[0062] 1. Gabapentin, purchased from Sigma, CAS Number: 60142-96-3.

[0063] 2. Gastrodin, provided by Kunming Pharmaceutical Factory, batch number: 200610036.

[0064] Just before use, grind and suspend 0.2% sodium carboxymethylcellulose in pure aqueous solution to a concentration of 45 mg / mL.

[...

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Abstract

The invention relates to 3-carbethoxy phenyl-beta-D-glucoside, or a pharmaceutically acceptable salt, ester or solvate thereof and application in preparing medicaments for treating neuropathic pains, wherein a glycosyl part is arbitrary pyranose or furanose; and a representative compound is 3-carbethoxy phenyl-beta-D-acylated xyloside the structural formula of which is disclosed in the specification. On a classical sciatic nerve chronic compression injury (CCI) model, through single intragastric administration and continuous intragastric administration for 7 days, the compound shows definite treatment effect on resisting nervous pains. At a dose point appointed by an experiment, the compound can obviously improve the mechanical stimulus pain threshold, the nervous pain resistant efficacy is equivalent to that of Gabapentin which is a contrast medicament, and the duration is superior to that of the Gabapentin. Proved by research results, the compound can be used for treating the chronic neuropathic pains.

Description

technical field [0001] The present invention relates to pharmaceutical compounds in the fields of medicine, hygiene and chemistry, in particular to 3-ethoxycarbonylphenyl-β-D-acylated glycoside compounds and pharmaceutically acceptable salts, esters and solvates thereof for the treatment of chronic neurogenic pain the use of. Background technique [0002] According to the duration of pain, pain is clinically classified into two types: acute pain and chronic pain. These two types of pain have essential differences in the mechanism of occurrence. Acute pain is called nociceptive pain, that is, pain caused by tissue trauma. With the repair of tissue trauma, the pain stops naturally. Analgesics, such as narcotic analgesics and non-steroidal antipyretic analgesics, can be used during the onset Chronic pain is mainly neurogenic pain, its pathogenesis is complex, and it is difficult to cure it. It is a new field of basic and clinical research and drug development of pain medicine....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/195A61P25/04A61P25/02A61P25/00
Inventor 戴晓畅肖涵
Owner YUNNAN UNIV
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