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Application of Angelica-Radix Hedysari ultrafiltration membrane extract in radiation protection

An ultrafiltration membrane and extract technology, applied in the direction of antitoxin, drug combination, plant raw materials, etc., can solve the problem of high toxicity and achieve the effect of improving bioavailability

Active Publication Date: 2010-09-08
GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the currently known drugs with radiation protection effects are relatively toxic, so people start with natural drugs to expect the development of drugs that are less toxic and suitable for clinical prevention and treatment of radiation damage.

Method used

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  • Application of Angelica-Radix Hedysari ultrafiltration membrane extract in radiation protection
  • Application of Angelica-Radix Hedysari ultrafiltration membrane extract in radiation protection
  • Application of Angelica-Radix Hedysari ultrafiltration membrane extract in radiation protection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The traditional Chinese medicinal materials used in the present invention are from Minxian County, Gansu Province, Angelica sinensis is purchased from the production base of Minxian County, and Hongqi is purchased from the Minxian County Medicinal Materials Station.

[0023] Decoction pieces of Angelica sinensis were decocted twice with water at a ratio of 1:5. The first time was added with 6 times the mass of the pieces and boiled for 2 hours, and the second time was added with 4 times the mass of the pieces and boiled for 1 hour. , merge the two decoctions and let stand overnight, filter the decoction to obtain the filtrate; the filtrate is then subjected to 100,000 molecular weight (molecular weight cut-off is 100,000) ultrafiltration membrane-polyethersulfone (PES) membrane ultrafiltration, and the ultrafiltration pressure is 0.3 Mpa, the temperature is 35 ℃, and the ultrafiltrate is spray-dried to make dry powder.

Embodiment 2

[0025] In order to show the effect of the present invention on protection against radiation hazards, the present invention carried out peripheral blood leukocyte count experiments, bone marrow cell DNA content determination experiments, mouse bone marrow cell micronucleus experiments, and blood superoxide dismutase (SOD) activity experiments on animals. , Serum hemolysin test.

[0026] 1. Experimental materials

[0027] 1.1 Animals

[0028] KM mice, SPF grade, male, weighing 20±2g, were provided by the Experimental Animal Center of Gansu College of Traditional Chinese Medicine, quality certificate number: SCXK (Gan) 2004-0006, experimental facility use certificate number: SYXK (Gan) 2004-0006. Animals were kept in separate cages and fed solid feed, which was provided by Beijing Keao Xieli Experimental Animal Feed Co., Ltd., with free water, room temperature 20-25°C, and relative humidity 45%-52%.

[0029] 1.2 Drugs and preparation

[0030] The ultrafiltration membrane extra...

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Abstract

The invention relates to an application method of an Angelica-Radix Hedysari ultrafiltration membrane extract in radiation protection. The method comprises the following steps of: taking tablets of Angelica and Radix Hedysari in the weight proportion of 1:5-6:6; adding 6 times of water to the Angelica tablets, and decocting for 2 hours; adding 4 times of water to the Radix Hedysari tablets, and decocting for 1 hour; mixing the decoction solutions, standing, and filtering to obtain a filtrate; ultrafiltering (20000-100000 molecular weight) the filtrate, and spray-drying the ultrafiltrate to obtain the dry powder. The invention carries out low-power X-ray one-shot total body radiation on a mouse by using a medical linear accelerator; the Angelica-Radix Hedysari ultrafiltration membrane extract water solution is respectively given to the mouse by gavage before and after the radiation; and the analysis on the variations of indices, such as peripheral blood leucocyte, spleen and thymus indices, DNA content in thighbone marrow cells, micronuclei number in marrow cells, superoxide dismutase (SOD) activity in blood, blood serum hemolysin and the like, indicates that the Angelica-Radix Hedysari ultrafiltration membrane extract has the function of radiation protection.

Description

technical field [0001] The invention relates to an ultrafiltration membrane extract of Angelica sinensis and Hengqi and its application for anti-radiation. Background technique [0002] With the development of the national economy and the improvement of people's living standards, radiation has become more and more closely related to people's work and life. Due to the extensive development of clinical radiotherapy and chemotherapy for cancer patients, and the application of nuclear energy and nuclear technology in agricultural production, With a large number of applications in medical and health care, scientific research and national defense equipment, the radiation damage of occupational exposed personnel has been paid more and more attention. However, most of the known drugs with radiation protection effect are relatively toxic, so people start from natural drugs and expect to develop drugs with low toxicity and suitable for clinical prevention and treatment of radiation da...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P39/00
Inventor 李应东
Owner GANSU LONGSHENRONGFA PHARMACEUTICAL INDUSTRY CO LTD
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