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Nanometer magnetic control throat anesthesia compound preparation and use thereof

An anesthesia compound and nano-magnetic technology are applied in the field of nano-magnetic controlled pharyngeal anesthesia compound preparations and their uses, which can solve the problems of lack of topical therapy and dosage forms of drugs, and achieve the effects of less adverse drug reactions, wide adaptability to the population, and reduced inspection costs.

Inactive Publication Date: 2010-09-01
杨书堂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] When suffering from throat tumor disease, there is still a lack of suitable topical therapy and dosage forms of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042]Embodiment 1: Accurately weigh lidocaine 15g, glycerin 60g, propylene glycol 40g, pour into 600ml deionized water, fully stir until fully dissolved, add bletilla striata gum 8g, pullulan 5g while stirring, fully stir until fully dissolved, Let it stand for 12-24 hours, and it will be liquid A. Take 30g of simethicone and 6g of compound emulsifier, mix well, fully grind or stir evenly, let stand for 10-30min, then slowly add 200ml of deionized water while stirring, stir well, add liquid A while stirring, stir 30min for liquid B, Fe 3 o 4 Heat 50ml of magnetic fluid to 50-60°C and add liquid B while stirring, add the remaining deionized water to 1000ml after stirring for 1 hour, adjust the pH to 6-7, and continue to alternately use mechanical stirring and ultrasonic dispersion twice each to get ready.

Embodiment 2

[0043] Example 2: Accurately weigh 10 g of dyclonine, 60 g of glycerin, and 40 g of propylene glycol, pour them into 600 ml of deionized water, fully dissolve them, add 12 g of bletilla striata gum, and 1 g of fine mushroom powder while stirring, fully dissolve them, Let it stand for 12-24 hours, and it will be liquid A. Take 25g of simethicone and 5g of compound emulsifier, mix well, fully grind or stir evenly, let stand for 10-30min, then slowly add 200ml of deionized water while stirring, stir well, add liquid A while stirring, stir 30min is B solution. Fe 3 o 4 Heat 80ml of magnetic fluid to 50-60°C and add liquid B while stirring, add the remaining deionized water to 1000ml after stirring for 1 hour, adjust the pH to 6-7, and continue to alternately use mechanical stirring and ultrasonic dispersion twice each.

Embodiment 3

[0044] Embodiment 3: Accurately weigh 10 g of lidocaine, pour into 800 ml of deionized water, fully stir 2.5 g of azithromycin until fully dissolved, add 8 g of bletilla striata gum while stirring, fully stir until completely dissolved with poloxamer, and let stand for 12 ~24 hours, it is liquid A. Fe 3 o 4 Heat 50ml of magnetic fluid to 50-60°C and add liquid A while stirring, add the remaining deionized water to 1000ml after stirring for 1 hour, adjust the pH to 6-7, and continue to alternately use mechanical stirring and ultrasonic dispersion twice each.

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PUM

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Abstract

The invention belongs to the technical field for applying a nanometer magnetic carrier material to medical treatment. Specifically, local anaesthetic and / or antibacterial anti-inflammation drug, anti-tumor drug, antifoaming agent and the like are added into the nanometer magnetic carrier material, particularly into the magnetic liquid, thereby achieving the use for assisting the gastroscopy and treating the inflammation and the tumor diseases of the throat. The invention can magnetically control the drug, locates the throat, can adjust the time, has good anesthesia and treatment effect, has less drug use amount and small side effect, has the performance characteristics of simple operation and low examination fee, and has the applying characteristics of wide material resource, simple manufacture technology and easy industrial production.

Description

technical field [0001] The invention belongs to the technical field of combining nano-magnetic materials and drugs for medical treatment, and specifically relates to loading local anesthetics and / or antibacterial and anti-inflammatory drugs, anti-tumor drugs, defoaming agents, etc. on nano-magnetic carrier materials, especially In the magnetic liquid, under the control of the magnetic field guidance applied on the periphery of the neck, the drug is positioned in the throat, so as to assist in gastroscopic examination, and to treat diseases such as throat inflammation and tumors. Background technique [0002] After Freemen first proposed magnetic particle preparations in the early 1960s, in the past 20 to 30 years, the theoretical and applied research on the preparation and treatment of magnetically controlled targeted drugs has made great progress, but most of them are anti-microbial agents prepared by using nano-magnetic solid particles. For tumor drugs, there are relativel...

Claims

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Application Information

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IPC IPC(8): A61K45/08A61K47/02A61K47/36A61K47/38A61K49/00A61P11/04A61P35/00
Inventor 杨书堂
Owner 杨书堂
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