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Preparation process of blood activating capsule

A preparation process and capsule technology are applied in the preparation technology field of Huoxue Capsules, which can solve the problems of large loss of active ingredients and high impurity content, and achieve the effects of stable product quality, safe and convenient operation, and improved purity.

Active Publication Date: 2010-07-14
西安大唐制药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation process of Huoxue Capsules, which solves the problems of large loss of active ingredients and high impurity content in the existing preparation process of Huoxue Capsules

Method used

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  • Preparation process of blood activating capsule
  • Preparation process of blood activating capsule
  • Preparation process of blood activating capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation process of the blood-activating capsule of the present embodiment comprises the following steps:

[0030] step 1,

[0031] By weight percentage, weigh 13% astragalus, 15% peach kernel, 10% safflower, 7% achyranthes bidentata, 4% jujube seed, 2% Chuanxiong, 8% red peony root, and 8% aurantia citrus , 7% rehmannia, 8% bellflower, 13% angelica, 5% licorice;

[0032] Step 2,

[0033] Rhizoma Chuanxiong is pulverized into a 200-mesh fine powder by ultrafine pulverization technology, and set aside;

[0034] Step 3,

[0035] Angelica sinensis and Fructus Fructus Fructus were crushed into 200-mesh fine powder by ultra-fine pulverization technology, and then the fine powder of Angelica sinensis and Fructus Fructus Fructus was placed in an extraction kettle and extracted with supercritical CO 2 As a solvent, the working pressure in the extraction kettle is controlled to be 9MPa, and the temperature in the kettle is 40°C, and the supercritical fluid extraction ...

Embodiment 2

[0045] The preparation process of the blood-activating capsule of the present embodiment comprises the following steps:

[0046] step 1,

[0047] By weight percentage, weigh 15% astragalus, 16% peach kernel, 13% safflower, 7% achyranthes bidentata, 4% jujube seed, 8% chuanxiong, 6% red peony root, and 10% aurantium fructus , 8% rehmannia, 4% bellflower, 8% angelica, 1% licorice;

[0048] Step 2,

[0049] Rhizoma Chuanxiong is pulverized into a 300-mesh fine powder by ultrafine pulverization technology, and set aside;

[0050] Step 3,

[0051] Angelica sinensis and Citrus aurantii were pulverized into 300 mesh fine powders by ultra-fine pulverization technology, and then the fine powders of Angelica sinensis and Citrus aurantii were placed in an extraction kettle and extracted with supercritical CO 2 As a solvent, control the working pressure in the extraction kettle to 12MPa, and the temperature in the kettle to 49°C for supercritical fluid extraction, and the extraction t...

Embodiment 3

[0061] The preparation process of the blood-activating capsule of the present embodiment comprises the following steps:

[0062] step 1,

[0063] By weight percentage, weigh 19% astragalus, 13% peach kernel, 7% safflower, 10% achyranthes bidentata, 7% jujube seed, 7% Chuanxiong, 4% red peony root, and 7% aurantium fructus , 13% rehmannia, 2% bellflower, 7% angelica, 4% licorice;

[0064] Step 2,

[0065] Rhizoma Chuanxiong is pulverized into a 300-mesh fine powder by ultrafine pulverization technology, and set aside;

[0066] Step 3,

[0067] Angelica sinensis and Citrus aurantii were pulverized into 300 mesh fine powders by ultra-fine pulverization technology, and then the fine powders of Angelica sinensis and Citrus aurantii were placed in an extraction kettle and extracted with supercritical CO 2 As a solvent, control the working pressure in the extraction kettle to 15MPa, and the temperature in the kettle to 33°C for supercritical fluid extraction, and the extraction t...

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Abstract

The invention discloses a preparation process of a blood activating capsule, which comprises the following steps that: first, angelica and citrus aurantium extract the fat-soluble effective ingredient groups through a supercritical CO2 extraction process, the fat-soluble effective ingredient groups are included by Beta-cyclodextrin to prepare inclusion volatile oil, herb residue and astragalus, peach kernel, safflower and other six Chinese medicines are decocted, the filtrate is concentrated into clear cream A, ethanol is added in so that the ethanol content is 65 percent, supernatant is taken out and the ethanol is recovered, and clear cream B is prepared by concentration; and finally clear cream C is purified by macroporous resin enrichment, the clear cream C is heated, sterilized, dried by microwave to prepare dry cream, and the dry cream is mixed with rhizoma ligustici wallichii fine powder and the included volatile oil and starch, boiled and granulated, and the capsule is filled. The preparation process of the blood activating capsule has the advantages that the blood activating capsule prepared has safe and reliable therapeutic effect and stable and controllable quality, abandons the ineffective and harmful ingredients in the Chinese medicine raw material, improves the medicine purity and reduces the dose of a patient.

Description

technical field [0001] The invention belongs to the technical field of a traditional Chinese medicine preparation process for treating qi deficiency and blood stasis and blood deficiency and blood stasis, and in particular relates to a preparation process of a blood-activating capsule. Background technique [0002] Traditional Chinese medicine has played an indelible contribution to the reproduction and prosperity of the Chinese nation. However, as an empirical medicine, traditional Chinese medicine has inherent shortcomings, such as: lack of modern clinical trial data and results provided by the principles of evidence-based medicine; mechanism of action and The active substances are not clear; there is a lack of strict quality control standards and methods. Therefore, it is difficult to ensure the quality requirements of "safety, effectiveness, stability and controllability" required by drugs. [0003] With the development of chemistry and modern analytical techniques, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/48A61P25/20A61P25/24A61P25/18A61P25/08
Inventor 仵博张明卫东
Owner 西安大唐制药集团有限公司
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