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Multipurpose utilization method for improving the value of schisandra chinensis medicinal material

A technology of Schisandra chinensis and Schisandra lignans, which can be applied in directions such as drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of less utilization of polysaccharide components, waste of resources, etc., and achieve the effect of improving comprehensive utilization value.

Inactive Publication Date: 2012-10-24
HARBIN RENHUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the utilization of Schisandra chinensis is mainly lignans, and the utilization of polysaccharide components is relatively small, while the utilization of other water-soluble components such as vitamins and organic acids is very little. , resulting in a serious waste of resources

Method used

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  • Multipurpose utilization method for improving the value of schisandra chinensis medicinal material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Soak Schisandra fruit statically in water for 24 hours, the solid-liquid ratio of fruit and water is 1:10 (w / v, g / mL), filter to obtain filtrate, which contains water-soluble active ingredients such as vitamins and organic acids, wherein The content of organic acid was 0.90% (g / mL).

[0015] Dry the above-mentioned Schisandra fruit soaked in water and grind it into powder, and use the following supercritical CO 2 Extraction method to extract active ingredient lignans: extraction pressure 35MPa, extraction temperature 50°C, CO 2 The flow rate is 12Kg / h, and dynamic extraction is carried out for 2 hours to obtain Schisandra lignan extract (the yield of Schisandra lignan extract is 1.02%) and residue raffinate;

[0016] Use hot water at 100°C to extract the residue raffinate, the ratio of solid to liquid between the residue raffinate and hot water is 1:25 (w / v, g / mL), the extraction time is 4 hours, the number of extractions is 5 times, and the extract is concentrated To...

Embodiment 2

[0018] Soak Schisandra fruit statically in water for 20 hours, the solid-liquid ratio of fruit and water is 1:8 (w / v, g / mL), filter to obtain filtrate, which contains water-soluble active ingredients such as vitamins and organic acids, wherein The content of organic acid was 1.08% (g / mL).

[0019] The above-mentioned Schisandra chinensis fruit after water immersion is dried and ground into powder, and the active ingredient lignan is extracted with the following alcohol extraction method: reflux extraction in ethanol solution, the solid-liquid ratio of fruit powder and ethanol solution is 1: 8 ( w / v, g / mL), the concentration of ethanol (can be medical alcohol or absolute ethanol) is 80% (v / v), the extraction time is 3 hours, the extraction times are 3 times, filtered, and the filtrate is concentrated to obtain Schizandra lignans Extract. The yield of Schizandra lignan extract was determined to be 1.13%.

[0020] Use hot water at 80°C to extract the alcohol extract residue, th...

Embodiment 3

[0022] Soak Schisandra fruit statically in water for 18 hours, the solid-liquid ratio of fruit and water is 1:6 (w / v, g / mL), filter to obtain filtrate, which contains water-soluble active ingredients such as vitamins and organic acids, wherein The organic acid content was 1.43% (g / mL).

[0023] After drying the Schisandra fruit soaked in water above, grind it into powder and use the following supercritical CO 2 Extraction method to extract active ingredient lignans: at extraction pressure 25MPa, extraction temperature 30°C, CO 2 The flow rate was 12 Kg / h, and dynamic extraction was carried out for 1 hour to obtain Schisandra lignan extract (the yield of Schisandra lignan extract was 0.49%) and residue raffinate.

[0024] Use hot water at 60°C to extract the residue raffinate, the ratio of solid to liquid between the residue raffinate and hot water is 1:10 (w / v, g / mL), the extraction time is 2 hours, the number of extractions is 2 times, and the extract is concentrated To 1 / 2...

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Abstract

The invention discloses a multipurpose utilization method for improving the value of schisandra chinensis medicinal material. The method includes that firstly, water-soluble active ingredients such as organic acid in the schisandra chinensis fruit are extracted by a water-soaking method, the soaked schisandra chinensis fruit is dried and grinded into powder, and then extracted by a supercritical carbon dioxide extraction method to produce schisandra chinensis lignanoids extractive and residue extractive, or extracted by an alcohol extraction method to produce schisandra chinensis lignanoids extractive or alcohol extractive residue; secondly, schisandra chinensis amylase is extracted from the residue extractive or alcohol extractive residue by a hot water extraction method. The method of the invention can simultaneously extract and utilize a plurality of chemical ingredients, such as lignanoids, amylase, vitamins and organic acid in the schisandra chinensis medicinal material, effectively improving the multipurpose utilization value of the medicinal material and providing a new way for utilization of the water-soluble ingredients and the residue of schisandra chinensis.

Description

technical field [0001] The invention relates to a comprehensive utilization method of schisandra chinensis, in particular to a comprehensive utilization method of multiple components such as lignans, polysaccharides, pigments, vitamins and organic acids in schisandra chinensis, belonging to the field of extraction and utilization of schisandra chinensis. Background technique [0002] Schisandra chinensis (Schisandra chinensis (Turcz.) Ball, commonly known as Northern Schisandra) or Huazhong Schisandra (S.sphenanthera Rehd.et Wils, commonly known as Southern Schisandra) is the dried and mature fruit of Magnoliaceae Schisandra (Schisandra chinensis (Turcz.) Ball, commonly known as Southern Schisandra). "Jing", is listed as the top grade, has the effect of restraining and astringent, replenishing qi and promoting body fluid, tonifying the kidney and calming the heart. Modern studies have proved that Schisandra chinensis contains not only lignans and polysaccharide active ingred...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57A61P39/06A61P25/00A61P1/16A61P9/00A61P35/00A61P31/18A61P11/00C08B37/00A61K131/00
CPCY02P20/54
Inventor 于喜水孟庆杰
Owner HARBIN RENHUANG PHARMA
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