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Combination for protecting peroxide injury of myocardium

A technology of myocardial peroxidation and composition, which is applied in the direction of active ingredients of hydroxyl compounds, drug combinations, cardiovascular system diseases, etc., can solve the problems of not being transformed into technical achievements, no patents, etc., to protect myocardial peroxidative damage, reduce fat Quality peroxidation reaction, excellent synergistic effect

Active Publication Date: 2011-11-16
BEIJING COMPETITOR SPORTS SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But the above are just some academic research, and have not been transformed into technical achievements, and there are no related patents

Method used

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  • Combination for protecting peroxide injury of myocardium
  • Combination for protecting peroxide injury of myocardium
  • Combination for protecting peroxide injury of myocardium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of preparation composition capsule of the present invention:

[0046] The selected raw materials coenzyme Q10, octacosanol and L-carnitine were sieved separately, and the materials under the 40 mesh sieve were selected as the raw materials for preparing the preparation combination.

[0047] Weigh the following raw materials respectively: 105g of coenzyme Q, 500g of L-carnitine, 100g of octacosanol, 17g of starch, and 3g of micropowdered silica gel, and then mix the components with similar weight ratios from small to large in equal volume, and stir well , poured into a capsule filling mold, filled with capsules, polished, subpackaged, and ready to be obtained.

Embodiment 2

[0049] The preparation of preparation composition granule of the present invention:

[0050] The selected raw materials coenzyme Q10, octacosanol and L-carnitine were sieved separately, and the materials under the 60-mesh sieve were selected as the raw materials for preparing the preparation combination.

[0051] Weigh the following raw materials: coenzyme Q10 50g, L-carnitine 100g, octacosanol 10g, sucrose powder 400g, dextrin 100g, and then mix the components with similar weight ratio from small to large in equal volume, fully Stir well.

[0052] Use 50% ethanol as a binder to make soft materials, pass the above soft materials through a YK-160 oscillating granulator with a 14-mesh screen to make granules, and put the granules into a DPL-30 multifunctional boiling dryer , boiling and drying at 50°C for about 40 minutes, controlling the moisture content of the granules at 5%, and then sizing the granules and subpackaging to obtain the product.

Embodiment 3

[0054] The preparation of preparation composition tablet of the present invention:

[0055] The selected raw materials coenzyme Q10, octacosanol and L-carnitine were sieved separately, and the materials under the 60-mesh sieve were selected as the raw materials for preparing the preparation combination.

[0056] Weigh the following raw materials respectively: 20g of coenzyme Q10, 150g of L-carnitine, 100g of octacosanol, 200g of lactose, 100g of microcrystalline cellulose, and 20g of sodium carboxymethyl starch. Mix small to large equal volumes, fully stir evenly, use 3% hydroxypropyl methylcellulose aqueous solution as a binder, and make soft materials, and pass the above soft materials through a YK-160 oscillating granulator with 18 mesh screens. To form granules, put the granules into a DPL-30 multifunctional boiling dryer, boil and dry at 50°C for about 40 minutes, control the water content of the granules at 4%-5%, then granulate, and then add a small amount of magnesium ...

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Abstract

The invention provides a combination for protecting peroxide injury of myocardium. The combination comprises the following raw materials (parts by weight of each raw material are shown in brackets): coenzyme Q100 (5 to 50), L-carnitine (10 to 500), and octocosanol (10 to 100). The combination can lessen lipid peroxidation of a myocardium cell membrane and improve the activity of antioxidant enzymes such as SOD, GSH-Px and CAT, thereby protecting the peroxide injury of the myocardium and delaying or eliminating sports fatigue.

Description

technical field [0001] The invention relates to a composition, in particular to a composition for protecting myocardial peroxidative damage and a preparation method thereof. Background technique [0002] Since Dillard first proposed the role of free radicals in sports fatigue and injury in 1978, the relationship between free radicals and sports fatigue has been paid more and more attention. It not only enriches the theory of sports fatigue, but also opens up a new way and method for preventing and eliminating sports fatigue. [0003] Many subsequent studies have found that strenuous or exhausting exercise can increase the production of free radicals in the body, increase the production of lipid peroxidation product MDA, and reduce the activity of antioxidant enzyme systems. Further studies have confirmed that antioxidant therapy can improve the endurance of the exercise body, scavenge free radicals, reduce lipid peroxidation, and increase the activity of antioxidant enzymes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/205A61K31/122A61K31/045A61P9/00A61P39/06
Inventor 白厚增焦颖杨则宜李奇庚李斌宋贵林
Owner BEIJING COMPETITOR SPORTS SCI & TECH
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