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Medicinal effervescent tablet for treating cough and preparation method thereof

An effervescent tablet and drug technology are applied in the field of drug effervescent tablets for treating cough and their preparation, and can solve the problems of inconspicuous effects of acute attacks and the like

Inactive Publication Date: 2012-11-28
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1520820 discloses a sustained-release pharmaceutical composition of levodropropizine, although it can maintain an effective blood drug concentration for a long period of time, it has no obvious effect on the acute attack of symptoms

Method used

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  • Medicinal effervescent tablet for treating cough and preparation method thereof
  • Medicinal effervescent tablet for treating cough and preparation method thereof
  • Medicinal effervescent tablet for treating cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Made into 1000 pieces

[0019] Preparation:

[0020] Prepare the prescription amount of polyethylene glycol 6000 and citric acid into an alcoholic aqueous solution, spray dry to obtain a solid dispersion of citric acid; fully mix levodropropizine and sodium bicarbonate, add lemon yellow pigment in an alcoholic aqueous solution, and granulate , drying at 40-60°C to obtain mixture I; fully mixing the solid dispersion of lactose and citric acid, adding an alcoholic aqueous solution of lemon yellow pigment, granulating, and drying at 40-60°C to obtain mixture II; Mix mixture I and mixture II, granulate with a granulator, add sodium stearyl fumarate, sucralose and lemon essence, press into tablets, pack, and obtain.

Embodiment 2

[0022]

[0023]

[0024] Made into 1000 pieces

[0025] Preparation:

[0026] Prepare the prescription amount of hydroxypropylmethylcellulose and tartaric acid into an alcoholic aqueous solution, spray dry to obtain a solid dispersion of tartaric acid; fully mix levodropropizine and calcium bicarbonate, add lemon yellow pigment in an alcoholic aqueous solution, and granulate. Dry at a temperature of 40-60°C to obtain a mixture I; fully mix the solid dispersion of mannitol and tartaric acid, add an alcoholic aqueous solution of lemon yellow pigment, granulate, and dry at a temperature of 40-60°C to obtain a mixture II; The mixture I and the mixture II are mixed, granulated by a granulator, and sodium stearyl fumarate, sucralose and lemon essence are added, compressed into tablets, packaged, and the product is obtained.

Embodiment 3

[0028]

[0029] Made into 1000 pieces

[0030] Preparation:

[0031] Formulate lactose and fumaric acid in the prescribed amount into an alcoholic aqueous solution, spray dry to obtain a solid dispersion of fumaric acid; fully mix levodropropizine and sodium bicarbonate, add lemon yellow pigment in an alcoholic aqueous solution, granulate, and Mixture I is obtained by drying at a temperature of 40-60°C, granulating with a granulator, adding a solid dispersion of fumaric acid, leucine, sucralose and lemon essence, pressing into tablets, and packaging.

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Abstract

The invention discloses a medicinal effervescent tablet for treating dry cough and persistent cough due to acute upper respiratory tract infection and acute bronchitis and a preparation method thereof, wherein, the effervescent tablet is composed of active levodropropizine, pretreated effervescent disintegrant, filler, flavouring agent, colorant and water-soluble lubricant.

Description

technical field [0001] The invention relates to a drug effervescent tablet suitable for dry cough and persistent cough caused by acute upper respiratory tract infection and acute bronchitis and a preparation method thereof, in particular to a pharmaceutical composition effervescent tablet containing levodropropizine The tablet is convenient to take, has a good taste and high stability, and has obvious effects on preventing and treating cough. Background technique [0002] With the development of modern industry, air pollution is becoming more and more serious, which makes the morbidity and mortality of respiratory diseases increase day by day. No matter at home or abroad, the incidence of respiratory diseases ranks first among many diseases in any age group. Cough is one of the main symptoms of respiratory diseases. Frequent and severe cough can affect rest and sleep, endanger health and lose its protective significance. Even accelerate the development of the disease, and m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K31/495A61P11/14
Inventor 袁筝
Owner BEIJING D VENTUREPHARM TECH DEV
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