Method for preparing gadolinium-containing nano particles
A nanoparticle and gadolinium salt technology is applied in the field of preparation of gadolinium-containing nanoparticles to achieve the effects of improving relaxation efficiency and contrast effect.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0038] Embodiment 1 Preparation of chitosan containing glycyrrhetinic acid group:
[0039] 1.1 Synthesis of carboxy-modified glycyrrhetinic acid derivatives:
[0040] Dissolve 4.70g of glycyrrhetinic acid in 30ml of N,N-dimethyl sulfoxide, cool, add 1.26g of diisopropylcarbodiimide, stir and add 1.15g of N-hydroxysuccinimide, at room temperature Stir the reaction, pour the reaction mixture into 100ml of absolute ethanol, collect the white solid, wash with 20ml of absolute ethanol, then wash with 10ml of absolute ether, and dry in vacuo to obtain the active ester of glycyrrhetinic acid;
[0041] Add the N,N-dimethylsulfoxide solution of glycyrrhetinic acid active ester dropwise to 200ml N,N-dimethylsulfoxide solution containing 28g of butanediamine, and react at 70°C for 15h, and the reaction solution Pour into 1000ml of water and place at 3°C. The precipitate was filtered, washed with 20 ml of ethanol and 100 ml of ether, dried, and the resulting precipitate was dissolved in...
Embodiment 2
[0045] Embodiment 2 Preparation of chitosan containing cholic acid groups:
[0046] 2.1 Synthesis of carboxy-modified cholic acid derivatives:
[0047] Dissolve 4.08g of cholic acid in 30ml of N,N-dimethylsulfoxide, cool, add 1.51g of diisopropylcarbodiimide, stir and add 1.38g of N-hydroxysuccinimide, and stir at room temperature For the reaction, the reaction mixture was poured into 140ml of absolute ethanol, and the white solid was collected, washed with 30ml of absolute ethanol, then washed with 20ml of anhydrous ether, and dried in vacuo to obtain the active ester of cholic acid;
[0048] Add the N,N-dimethylsulfoxide solution of bile acid active ester dropwise to 200ml N,N-dimethylsulfoxide solution containing 30g of butanediamine, and react at 70°C for 15h, and the reaction solution Pour into 1000ml of water and place at 3°C. The precipitate was filtered, washed with 25 ml of ethanol and 100 ml of ether, dried, and the obtained precipitate was dissolved in N,N-dimethy...
Embodiment 3
[0052] Example 3 Preparation of polylysine containing folic acid groups:
[0053] 3.1 Synthesis of carboxy-modified folic acid derivatives:
[0054] Dissolve 4.41g of folic acid in 30ml of N,N-dimethyl sulfoxide, cool, add 1.62g of diisopropylcarbodiimide, stir and add 1.42g of N-hydroxysuccinimide, and stir the reaction at room temperature , the reaction mixture was poured into 140ml of absolute ethanol, the white solid was collected, washed with 30ml of absolute ethanol, then washed with 20ml of anhydrous ether, and vacuum-dried to obtain the active ester of folic acid;
[0055] Add the N,N-dimethylsulfoxide solution of folic acid active ester dropwise to 200ml N,N-dimethylsulfoxide solution containing 34g butanediamine, react at 70°C for 15h, pour the reaction solution Pour into 1000ml of water and place at 3°C. The precipitate was filtered, washed with 25 ml of ethanol and 100 ml of ether, dried, and the obtained precipitate was dissolved in N,N-dimethylformamide, precip...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com