Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biodegradable polymer hpma-gd magnetic resonance imaging probe and preparation method thereof

A magnetic resonance imaging and biodegradable technology, applied in the field of medical imaging, can solve the problems of low sensitivity, non-specificity, and difficulty in achieving satisfactory imaging effects, and achieve the goals of improving aggregation, high-efficiency biocompatibility, and prolonging cycle time Effect

Active Publication Date: 2019-09-06
SICHUAN UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, they all belong to small molecular magnetic resonance imaging probes, which have disadvantages such as low sensitivity, non-specificity, and rapid clearance from the body; and they mainly pass passive diffusion into the tumor stroma or tissue stroma, making it difficult to achieve satisfactory results. Imaging effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable polymer hpma-gd magnetic resonance imaging probe and preparation method thereof
  • Biodegradable polymer hpma-gd magnetic resonance imaging probe and preparation method thereof
  • Biodegradable polymer hpma-gd magnetic resonance imaging probe and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A biodegradable polymeric HPMA-Gd magnetic resonance imaging probe, the chain structure is as follows:

[0043]

[0044] Among them: m:n:o=35~45:410~450:65~70;

[0045]

[0046] The order of the C, B and A groups in the system is not fixed, and the R group can be connected to any one of C, B and A.

Embodiment 2

[0048] On the basis of embodiment 1:

[0049] Wherein, R1 is SH, m:n:o=35:410:65.

[0050] The average molecular weight of the magnetic resonance imaging probe is 85KDa.

Embodiment 3

[0052] On the basis of embodiment 1:

[0053] Wherein, R1 is not SH, m:n:o=45:450:70.

[0054] The average molecular weight of the magnetic resonance imaging probe is 94KDa.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a biodegradable poly-HPMA-Gd magnetic resonance imaging probe, which inserts the enzyme-sensitive polypeptide GFLG into the poly-HPMA main chain structure; the molecular weight of the prepared polymer is basically controllable, and the molecular weight polydispersity coefficient ( PDI) is low; and linearized HPMA-DOTA-Gd is obtained by coupling with Gd(III). The probe is a high-efficiency biocompatible nanoscale MRI magnetic resonance imaging probe, which can be used for clinical tumor diagnosis and adjuvant therapy.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and relates to a polymer magnetic resonance imaging probe, in particular to a biodegradable polymeric HPMA-Gd magnetic resonance imaging probe. Background technique [0002] Due to the advantages of high spatial resolution, 3D image information and no radioactivity, magnetic resonance imaging (MRI) has become an effective non-invasive diagnosis method for tumors. According to incomplete statistics, more than 50% of clinical MRI tumor diagnosis requires the use of MRI magnetic resonance imaging probes. Commonly used clinical MRI magnetic resonance imaging probes include gadoterate meglumine (Magnevist) and gadoterate meglumine (Dotarem). However, they all belong to small molecular magnetic resonance imaging probes, which have the disadvantages of low sensitivity, non-specificity, and rapid clearance from the body; and they mainly pass passive diffusion into the tumor stroma or tissue stro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/12A61K49/14A61K49/18
Inventor 罗奎龚启勇
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com