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Medical composition for losing weight or treating metabolic syndromes

A technology for metabolic syndrome and composition, applied in the directions of drug combination, metabolic disease, pharmaceutical formulation, etc., can solve problems such as no reports of orlistat or celistat combined with heparin drugs, etc. The effect of reducing arterial pressure, overcoming increased pulse pressure, and enhancing glucose tolerance

Active Publication Date: 2010-06-30
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no reports of orlistat or selistat combined with heparin drugs at home and abroad.

Method used

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  • Medical composition for losing weight or treating metabolic syndromes
  • Medical composition for losing weight or treating metabolic syndromes
  • Medical composition for losing weight or treating metabolic syndromes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] prescription

[0016] Orlistat 150g

[0017] Ultra Low Molecular Heparin Sodium 50U

[0018] Microcrystalline Cellulose 200g

[0019] Appropriate amount of starch slurry

[0020] Low-substituted hydroxypropyl cellulose 190g

[0021] Magnesium Stearate 5g

[0022] Preparation process: Weigh the prescribed amount of orlistat, heparin sodium and other auxiliary materials, and prepare compressed tablets according to the conventional tablet preparation technology.

Embodiment 2

[0024] Orlistat 10g

[0025] Calcium Heparin 2500U

[0026] 100g pregelatinized starch

[0027] Mannitol 85g

[0028] Starch 50g

[0029] 6% PVP in 95% ethanol solution

[0030] Micronized silica gel 3.5g

[0031] Preparation process: Pass orlistat, heparin calcium, mannitol, starch and micropowder silica gel in the prescription through a 100-mesh sieve, mix well, add 6% PVP in 95% ethanol solution to granulate in appropriate amount, dry at 60°C, and dry for 18 Mesh sieve for granulation, then fill the capsules.

Embodiment 3

[0033] Orlistat 60g

[0034] Potassium Heparin 1000U

[0035] Croscarmell Starch Sodium 150g

[0036] Microcrystalline Cellulose 75g

[0037] Ethylcellulose 4g

[0038] Magnesium Stearate 4g

[0039] Preparation process: Weigh the prescribed amount of orlistat, heparin sodium and other auxiliary materials, and prepare compressed tablets according to the conventional sustained-release tablet preparation technology.

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PUM

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Abstract

The invention discloses a medical composition for treating metabolic syndromes, belonging to the field of medicines, and in particular relates to a medical composition containing orlistat or cetilistat and heparin, wherein the composition is solid preparations such as compressed tablets, dispersible tablets, sustained release tablets, capsules, granules, and the like. In experiments, the medical composition containing the orlistat or the cetilistat and the heparin is accidentally found to have obvious synergistic effect on the aspects of reducing the blood pressure, the serum total cholesterol, the serum triglyceride and the low density lipoprotein cholesterin and enhancing the carbohydrate tolerance.

Description

technical field [0001] The invention relates to a pharmaceutical composition for weight loss or treatment of metabolic syndrome, which belongs to the field of medicine. Background technique [0002] Overweight or obesity, accompanied by a series of diseases such as hypertension, hyperlipidemia, hyperglycemia, atherosclerosis and hyperinsulinemia, this phenomenon is called metabolic syndrome in medicine. Metabolic syndrome is a common physical problem faced by the urban population. It can not only increase the risk of diabetes and cardiovascular and cerebrovascular diseases, but also increase the mortality of cardiovascular and cerebrovascular diseases. Metabolic syndrome is a polygenic, hereditary disease and is influenced by the environment. Its clinical feature is the combination of obesity, dyslipidemia, hyperglycemia and hypertension. And these four kinds of diseases are often "collusion", which is the "death quartet" of modern urban people. Therefore, experts appeal ...

Claims

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Application Information

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IPC IPC(8): A61K31/727A61K31/536A61K31/365A61P3/04A61P3/00A61P9/12
Inventor 赵志全李欣
Owner LUNAN PHARMA GROUP CORPORATION
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