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Method for preparing vitamin C with low consumption

A vitamin and low-consumption technology, applied in the direction of organic chemistry and the like, can solve the problems of low crystal purity of sodium cologne, the total yield of the product needs to be further improved, etc., to shorten the production cycle, solve the problem of difficult removal, and improve the conversion rate.

Inactive Publication Date: 2010-06-23
HEBEI WELCOME PHARMACEUTICAL CO LTD +1
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  • Abstract
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  • Application Information

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Problems solved by technology

But the purity of the sodium gulonate crystal prepared by this method is relatively low, so it has not been applied to production, and the total yield of the product also needs to be further improved

Method used

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  • Method for preparing vitamin C with low consumption
  • Method for preparing vitamin C with low consumption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] according to figure 1 Process shown:

[0022] a: Prepare vitamin C according to a conventional two-step fermentation method, ferment sorbitol to obtain gulonic acid fermented mash, and stir evenly with 1% chitosan and 1‰ polyacrylamide solution added to the fermented mash;

[0023] b: Then add 15% NaOH solution to adjust the pH of the solution to 8;

[0024] c: Pass the above-mentioned mash through a cellulose acetate membrane with a molecular weight of 50,000, pass the filtrate through an activated carbon decolorization column, and then obtain sodium guronate crystals according to the usual methods of concentration, crystallization and centrifugation;

[0025] d: the esterification reaction carried out by sodium guronate crystals with methanol and concentrated sulfuric acid, its dosage ratio is: sodium guronate crystals: methyl alcohol=1kg: 5L; sodium guronate: H 2 SO 4 (98%) is 1Kg:0.13L, the reaction temperature is 66-67°C, the reaction time is 4 hours, and the pH...

Embodiment 2

[0030] a: Prepare vitamin C according to a conventional two-step fermentation method, ferment sorbitol to obtain gulonic acid fermentation mash, and stir the 2% chitosan solution added in the fermentation mash evenly;

[0031] b: Then add 12% NaOH solution to adjust the pH of the solution to 10;

[0032] c: Pass the above-mentioned mash through a cellulose acetate membrane with a molecular weight of 30,000, pass the filtrate through an activated carbon decolorization column, and then obtain sodium guronate crystals according to the usual methods of concentration, crystallization and centrifugation;

[0033] d: the esterification reaction carried out by sodium guronate crystals with methanol and concentrated sulfuric acid, its dosage ratio is: sodium guronate crystals: methanol=1kg: 3L; sodium guronate: H 2 SO 4 (98%) is 1Kg:0.19L, the reaction temperature is 66°C, the reaction time is 4 hours, and the pH is controlled at 1.9.

[0034] e: The above reaction solution is added ...

Embodiment 3

[0038] Prepare vitamin C according to the conventional two-step fermentation method, ferment corn to obtain gulong acid fermentation mash, add chitosan solution in the fermentation mash according to the mass ratio of chitosan and fermentation mash to 2%, and then add the chitosan solution according to the mass ratio to 1‰, add polyacrylamide and stir evenly, then add 10% NaOH to adjust the pH of the solution to 10; decolorize the filtrate from membrane filtration to obtain sodium guronate crystals, and carry out esterification reaction, first add 2500ml of methanol, then add 600g of sodium guronate , finally slowly add 84.5ml of concentrated sulfuric acid, control PH = 2.1, esterify for 4.5 hours, cool down, slowly add NaHCO 3 158g reacted for 2 hours, then added Na 2 CO 3 React 80g for 2 hours, control PH = 7, acidify directly after the reaction, add an appropriate amount of water to make the methanol concentration of the system 82% to 84%, slowly add an appropriate amount o...

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Abstract

The invention discloses a method for preparing vitamin C with low consumption, which comprises the following steps: (a) preparing fermented liquor produced by the vitamin C through a two-step fermentation method, and adding a flocculating agent into the fermented liquor to perform sediment; (b) adding strong alkali into the fermented liquor to adjust the pH value; (c) performing member ultra-filtration and decolorizing treatment on the fermented liquor to obtain sodium gulonate crystal; and (d) performing esterification reaction, conversion reaction and acidification reaction on the sodium gulonate crystal, and filtering the reaction product to obtain coarse Vc. The method further improves the quality and increases the yield of the vitamin C, simplifies the production process and reduces the production and manufacturing costs.

Description

technical field [0001] The invention relates to a method for synthesizing organic compounds, in particular to a method for preparing vitamin C. Background technique [0002] At present, the production of vitamin C usually adopts a two-step fermentation method, that is, fermenting sorbitol to obtain sodium guronate fermentation liquid; the fermentation liquid is transformed into a gulong acid solution after membrane ultrafiltration and cation exchange; the guron acid solution is then concentrated, crystallized, Gulonic acid crystals were obtained by centrifugation; Gulonic acid crystals were mixed with methanol in a certain proportion, esterification reaction occurred under the action of sulfuric acid catalyst, and then NaHCO was added 3 Transformation is carried out, and crude vitamin C is finally obtained through subsequent processing. The process is to remove sodium ions from gulonate sodium solution through cationic resin exchange to obtain guronic acid crystals. In thi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/62
Inventor 米造吉崔永涛王宏民周华芮谢萍卢雪娟张战峰
Owner HEBEI WELCOME PHARMACEUTICAL CO LTD
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